Cell Communication and the Control of Endothelial Cell Growth

2015 ◽  
pp. 183-191
Author(s):  
Kim B. Saunders ◽  
Alicia Antonelli-Orlidge ◽  
Sandra Smith ◽  
Patricia A. D�Amore
Keyword(s):  
Endothelial Cell ◽  
Cell Growth ◽  
Cell Communication ◽  
Endothelial Cell Growth

NOR-1 is involved in VEGF-induced endothelial cell growth

2006 ◽  
Vol 184 (2) ◽  
pp. 276-282 ◽  
Author(s):  
Jordi Rius ◽  
José Martínez-González ◽  
Javier Crespo ◽  
Lina Badimon
Keyword(s):  
Endothelial Cell ◽  
Cell Growth ◽  
Endothelial Cell Growth

Endothelial Cell Growth and Protein Adsorption on Terminally Functionalized, Self-Assembled Monolayers of Alkanethiolates on Gold

Langmuir ◽  
1997 ◽  
Vol 13 (13) ◽  
pp. 3404-3413 ◽  
Author(s):  
Caren D. Tidwell ◽  
Sylvie I. Ertel ◽  
Buddy D. Ratner ◽  
Barbara J. Tarasevich ◽  
Sundar Atre ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Growth ◽  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Endothelial Cell Growth ◽  
Self Assembled

Dose-dependent endothelial cell growth and stiffening by aldosterone: endothelial protection by eplerenone

2007 ◽  
Vol 25 (3) ◽  
pp. 639-647 ◽  
Author(s):  
Uta Hillebrand ◽  
Hermann Schillers ◽  
Christoph Riethmüller ◽  
Christian Stock ◽  
Marianne Wilhelmi ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Growth ◽  
Endothelial Cell Growth ◽  
Dose Dependent

Abstract 3640: Mitochondrial Uncoupling Protein 2 Facilitates Endothelial Cell Growth and Angiogenesis via Reduction of Mitochondrial Superoxide

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Yukio Shimasaki ◽  
Kai Chen ◽  
John F Keaney
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Cell Growth ◽  
Mitochondrial Function ◽  
Endothelial Cell Proliferation ◽  
Wild Type ◽  
Sprouting Angiogenesis ◽  
Mitochondrial Superoxide ◽  
Endothelial Cell Growth ◽  
Aortic Explants

Background: Growing evidence suggests that mitochondrial function contributes to cell phenotype. One important component of mitochondrial function is the membrane potential that is controlled, in part, by uncoupling proteins (UCPs). Based on our previous data, the UCP2 is predominantly expressed in cultured endothelial cells. Therefore, we sought to examine the role of UCP2 in endothelial cell growth and angiogenesis. Methods and Results: Murine lung endothelial cells (MLECs) were isolated from UCP2-null and wild-type mice. UCP2-null cells were found less proliferative than wild-type cells (P<0.02, UCP2-null cells vs. wild-type cells, n=4). This defect of UCP2-null cells was rescued by UCP2 adenovirus transfection (19% increase, p<0.02 vs. LacZ adenovirus treated cells, n=3), and also rescued by transfection with manganese superoxide dismutase (MnSOD) adenovirus (53% increase, P<0.002 vs. LacZ adenovirus treated cells, n=3). We found a reciprocal relation such as no UCP2 expression and higher mitochondrial superoxide level in the MLECs (P<0.005, UCP2-null cells vs. wild-type cells, n=3), suggesting that mitochondrial superoxide may regulate endothelial cell growth. Then, we prepared murine aortic rings from UCP2-null and wild-type mice and embedded in rat tail collagen gel. The sprouting angiogenesis of UCP2-null explants was significantly less than wild-type explants (P<0.02, UCP2-null explants vs. wild-type explants, n=3– 4). Furthermore, MLECs from MnSOD-heterozygous mice showed less proliferation with lower expression of UCP2 protein and higher mitochondrial superoxide level compared to the MLECs from wild-type littermates (P<0.02, MnSOD-heterozygous cells vs. wild-type cells, n=4 – 8). We also observed less sprouting angiogenesis in MnSOD-heterozygous aortic explants than wild-type aortic explants (P<0.05, MnSOD-heterozygous explants vs. wild-type explants, n=3– 6). Conclusions: These data indicate that mitochondrial superoxide controls endothelial cell proliferation and angiogenesis, suggesting that mitochondrial metabolism modulates the endothelial cell growth and angiogenesis.

Sign in / Sign up

Export Citation Format

Share Document