Human Antimouse Antibody Response in Patients Treated with Multiple Infusions of Monoclonal Antibody CO17-1A

2015 ◽  
pp. 69-72 ◽  
Author(s):  
Zenon Steplewski ◽  
Kevin Fox ◽  
John Glick ◽  
Hilary Koprowski
Keyword(s):  
Monoclonal Antibody ◽  
Antibody Response ◽  
Human Antimouse Antibody

scholarly journals Cross-reactive antibody response to mRNA SARS-CoV-2 vaccine after recent COVID-19-specific monoclonal antibody therapy

2021 ◽  
Author(s):  
Stacey Schultz-Cherry ◽  
Maureen A McGargill ◽  
Paul G Thomas ◽  
Jeremie H Estepp ◽  
Aditya H Gaur ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Immune Responses ◽  
Antibody Response ◽  
Antibody Therapy ◽  
Antibody Responses ◽  
Monoclonal Antibody Therapy ◽  
Receptor Binding Domain ◽  
Specific Monoclonal Antibody ◽  
Vaccine Failure ◽  
Reactive Antibody

Abstract Efficacy of COVID-19 vaccines administered after COVID-19-specific monoclonal antibody is unknown, and ‘antibody interference’ might hinder immune responses leading to vaccine failure. In an IRB-approved prospective study, we found that an individual who received mRNA COVID-19 vaccination <40 days after COVID-19-specific monoclonal antibody therapy for symptomatic COVID-19 had similar post-vaccine antibody responses to SARS-CoV-2 receptor binding domain (RBD), for four important SARS-CoV-2 variants (B.1, B.1.1.7, B.1.351 and P.1), as other participants who were also vaccinated following COVID-19. Vaccination against COVID-19 shortly after COVID-19-specific monoclonal antibody can boost and expand antibody protection, questioning the need to delay vaccination in this setting.

Characterization of Primate Antibody Responses to Administered Murine Monoclonal Immunoglobulin

1990 ◽  
Vol 5 (4) ◽  
pp. 177-187 ◽  
Author(s):  
D.E. Milenic ◽  
B. Detrick ◽  
J.C. Reynolds ◽  
D. Colcher
Keyword(s):  
Monoclonal Antibody ◽  
Antibody Response ◽  
Solid Phase ◽  
Hypervariable Region ◽  
Antigen Binding ◽  
Post Inoculation ◽  
Antigen Binding Site ◽  
Antibody Treatment ◽  
Cancer Management ◽  
Monoclonal Antibody Treatment

Murine monoclonal antibodies (MAb) are currently being assessed for their utility as tools in cancer management. Anti-murine immunoglobulin responses have been observed in many patients receiving monoclonal antibody treatment. In this study, we evaluated the response of primates to the administration of a monoclonal antibody. MAb B6.2, an antibody generated against a human breast tumor metastasis, was used as a prototype MAb. Baboons were inoculated with MAb B6.2 whole IgG, Fab', or F(ab')2 fragments. Blood samples were drawn at periodic intervals post-inoculation and the sera collected. Anti-murine immunoglobulin responses were detected using a solid-phase radioimmunoassay. The specificity of the antibody response was analyzed to determine if the response was directed against the species of origin of the MAb (species specificity), against the class of the MAb (isotype specificity), or against the hypervariable region of the MAb (idiotype specificity). We found that primates develop a humoral immune response against all three forms of the monoclonal antibody [IgG, Fab', and F(ab')2]. Furthermore, this antibody response demonstrated a high degree of specificity for the antigen binding site suggesting an idiotypic specificity. Using a competitive radioimmunoassay, the antibody response was found to interfere with antigen binding of MAb B6.2. These studies suggest that monoclonal antibody treatment can generate an anti-idiotypic response which may alter the efficacy of this mode of treatment.

scholarly journals Lipid Modification and Monoclonal Antibody Response to an Epitope of Oxidized LDL Following Vitamin E Supplementation in Children with Hyperlipidemia

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 31A-31A
Author(s):  
Robert Steelman ◽  
Kumravel Rajakumar ◽  
William Neal ◽  
David Rosen ◽  
Stanley Einzig ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Vitamin E ◽  
Antibody Response ◽  
Oxidized Ldl ◽  
Lipid Modification ◽  
Vitamin E Supplementation
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