Direct and Neural-Mediated Mechanisms of Upper and Lower Airway Responses to Inhaled Antigen

2015 ◽  
pp. 19-25
Author(s):  
G. U. Di Maria ◽  
S. Bellofiore ◽  
A. Mistretta
Keyword(s):  
Lower Airway ◽  
Airway Responses

THE EFFECTS OF INTRANASAL STEROIDS ON NASAL AND PULMONARY RESPONSES TO CAT EXPOSURE

PEDIATRICS ◽  
1996 ◽  
Vol 98 (2) ◽  
pp. 327-327
Author(s):  
Stanley J. Szefler
Keyword(s):  
Corticosteroid Treatment ◽  
Lower Airway ◽  
Intranasal Corticosteroid ◽  
Intranasal Steroids ◽  
Airway Responses

Intranasal corticosteroid treatment led to significant reductions in both upper and lower airway responses to intense cat exposure.

scholarly journals Lower airway responses to rhinovirus 39 in healthy allergic and nonallergic subjects

1996 ◽  
Vol 9 (7) ◽  
pp. 1402-1406 ◽  
Author(s):  
D.P. Skoner ◽  
W.J. Doyle ◽  
J. Seroky ◽  
M.A. Van Deusen ◽  
P. Fireman
Keyword(s):  
Lower Airway ◽  
Airway Responses

Comparison of upper and lower airway responses of two sensitized rat strains to inhaled antigen

1992 ◽  
Vol 73 (4) ◽  
pp. 1608-1613 ◽  
Author(s):  
L. J. Xu ◽  
S. Sapienza ◽  
T. Du ◽  
S. Waserman ◽  
J. G. Martin
Keyword(s):  
Upper Airway ◽  
Brown Norway ◽  
Lower Airway ◽  
Sprague Dawley ◽  
Pulmonary Resistance ◽  
Upper Airways ◽  
Tracheal Pressure ◽  
Airway Response ◽  
Airway Responses ◽  
Inbred Rat

The purpose of the study was to investigate the relationships between upper airways responses and pulmonary responses of two strains of highly inbred rats to inhaled antigen. To do this we measured the upper and lower airways resistance for 60 min after challenge of Brown-Norway rats (BN; n = 13) and an inbred rat strain (MF; n = 11), derived from Sprague-Dawley, with aerosolized ovalbumin (OA). Rats were actively sensitized with OA (1 mg sc) using Bordetella pertussis as an adjuvant. Two weeks later the animals were anesthetized and challenged. Tracheal pressure, esophageal pressure, and airflow were measured, from which total pulmonary resistance was partitioned into upper airway and lower pulmonary resistance (RL). The peak upper airway response to inhaled OA was similar in BN (1.89 +/- 0.66 cmH2O.ml-1.s; n = 7) and MF (2.85 +/- 0.68 cmH2O.ml-1.s; n = 6). The lower airway response to OA challenge was substantially greater in BN, and RL changed from 0.07 +/- 0.01 to 0.34 +/- 0.13 (n = 6; P < 0.05). The MF did not have any significant increase in RL after challenge; the baseline RL was 0.12 +/- 0.02 and only reached a peak value of 0.15 +/- 0.05 (n = 5; P = NS). Lower airway responsiveness of BN (n = 10) to serotonin, an important mediator early allergic airway responses, was similar to MF (n = 7).(ABSTRACT TRUNCATED AT 250 WORDS)

123 Determinants of upper and lower airway responses to cat exposure

1991 ◽  
Vol 87 (1) ◽  
pp. 169
Author(s):  
R WOOD ◽  
P TRENT ◽  
K MUDD ◽  
S BOWES ◽  
P EGGLESTON
Keyword(s):  
Lower Airway ◽  
Airway Responses

The upper and lower airway responses to nasal challenge with house-dust mite Blomia tropicalis

Allergy ◽  
2003 ◽  
Vol 58 (1) ◽  
pp. 78-82 ◽  
Author(s):  
D. Y. Wang ◽  
D. Y. T. Goh ◽  
A. K. L. Ho ◽  
F. T. Chew ◽  
K. H. Yeoh ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Lower Airway ◽  
Blomia Tropicalis ◽  
Nasal Challenge ◽  
Dust Mite ◽  
Airway Responses

Partitioning of airway responses to inhaled methacholine in the rat

1987 ◽  
Vol 62 (3) ◽  
pp. 1317-1323 ◽  
Author(s):  
G. U. DiMaria ◽  
C. G. Wang ◽  
J. H. Bates ◽  
R. Guttmann ◽  
J. G. Martin
Keyword(s):  
Airway Resistance ◽  
Upper Airway ◽  
Lower Airway ◽  
Control Value ◽  
Upper Airway Resistance ◽  
Lower Airways ◽  
Airway Responses ◽  
Spontaneously Breathing

We measured the changes in upper and lower airway resistance after inhalation of aerosols of methacholine (MCh) in doubling concentrations (16, 32, 64, and 128 mg/ml) in 11 anesthetized nonintubated spontaneously breathing rats. Upper airway resistance (Ru) increased from a control value of 0.48 +/- 0.04 cmH2O X ml-1 X s (mean +/- SE) to 0.85 +/- 0.15 after 128 mg/ml MCh, whereas lower airway resistance (Rlo) increased from 0.11 +/- 0.03 to 0.21 +/- 0.04. However, there was no correlation between the magnitudes of the changes in Ru and Rlo. In a further seven anesthetized spontaneously breathing rats aerosols of MCh were delivered into the lower airways via a tracheostomy and resulted in increases in Rlo from a control value of 0.20 +/- 0.03 to 0.66 +/- 0.12 after 128 mg/ml MCh. Ru also increased to approximately double its control value. We conclude that inhaled MCh causes narrowing of both Ru and Rlo in the anesthetized rat, the changes in Ru and Rlo are not correlated, and changes in Ru can occur when MCh deposition occurs only in the lower airways.

Lower airway responses to rhinovirus-Hanks in healthy subjects with and without allergy

1997 ◽  
Vol 99 (5) ◽  
pp. 618-619 ◽  
Author(s):  
B ANGELINI ◽  
M DEUSEN ◽  
W DOYLE ◽  
J SEROKY ◽  
S COHEN ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Lower Airway ◽  
Airway Responses

Airway Responses to Deep Inspiration in Asthma by Different Bronchial Challenge

2012 ◽  
Vol 18 (2) ◽  
pp. 75-80
Author(s):  
Chang-Wook Min ◽  
An-Soo Jang ◽  
Young-Seok Ji ◽  
Nam-Jun Cho ◽  
Kang-Hyug Choi ◽  
...  
Keyword(s):  
Deep Inspiration ◽  
Bronchial Challenge ◽  
Airway Responses
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