Thyroid-Stimulating Hormone Growth-Responsive, Cyclic Adenosine Monophosphate-Unresponsive Poorly Differentiated Thyroid Carcinoma of Follicular Cell Origin1

2015 ◽  
pp. 81-87 ◽  
Author(s):  
A. E. Siperstein ◽  
H. van Raavenswaay Claasen ◽  
R. Miller ◽  
M. M. Bhattathiry ◽  
M. Hughes-Fulford ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Differentiated Thyroid Carcinoma ◽  
Thyroid Stimulating Hormone ◽  
Follicular Cell ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated ◽  
Stimulating Hormone

Unusual Finding on Ultrasonography of Follicular Thyroid Carcinoma Including Poorly Differentiated Thyroid Carcinoma

Thyroid ◽  
2008 ◽  
Vol 18 (9) ◽  
pp. 1021-1022 ◽  
Author(s):  
Minoru Kihara ◽  
Nobuyuki Amino ◽  
Mitsuyoshi Hirokawa ◽  
Fumio Matsuzuka ◽  
Akira Miyauchi
Keyword(s):  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated ◽  
Unusual Finding

scholarly journals Rapid Bioassay for Detection of Thyroid-Stimulating Antibodies Using Cyclic Adenosine Monophosphate-Gated Calcium Channel and Aequorin

2015 ◽  
Vol 4 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Naohiro Araki ◽  
Mitsuru Iida ◽  
Nobuyuki Amino ◽  
Shinji Morita ◽  
Akane Ide ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Hormone Receptor ◽  
Chinese Hamster ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Thyroid Stimulating Hormone ◽  
Ovary Cell ◽  
Intracellular Camp ◽  
Thyroid Stimulating Antibodies ◽  
Stimulating Hormone

Background: Thyroid-stimulating antibodies (TSAb) are known to be responsible for hyperthyroidism in Graves' disease (GD). The conventional methods to measure TSAb depend on cell-based assays that require cumbersome procedures and a sterilized tissue culture technique. The aim of the present study was to develop a ready-to-use cell-based assay for measuring TSAb activity without requiring sterilized conditions. Methods: We developed a new assay kit using a frozen Chinese hamster ovary cell line expressing the thyroid-stimulating hormone receptor, cyclic adenosine monophosphate (cAMP)-gated calcium channel and aequorin, tentatively named the aequorin TSAb assay. Activated stimulatory G-protein-coupled adenylate cyclase increases intracellular cAMP, which then binds to the cyclic nucleotide-gated calcium channel. Activation of this channel allows Ca2+ to enter the cell, and the influx of Ca2+ can be measured with aequorin, which is quantified by a luminometer. Results can be obtained in only 4 h without sterilized conditions. TSAb activities were expressed by international units using the NIBSC 08/204 standard. Results: Positive results of aequorin TSAb were obtained in 197 of 199 (98.9%) of untreated patients with GD. Only 1 of 42 (2.3%) patients with painless thyroiditis had a weakly positive aequorin TSAb. All 45 patients with subacute thyroiditis and 185 normal subjects showed negative aequorin TSAb. As for chronic thyroiditis, all 52 euthyroid patients showed negative aequorin TSAb, but 8 of 50 (16.0%) hypothyroid patients had a positive reaction. However, these positive reactions were not induced by serum thyroid-stimulating hormone (TSH) and were thought to be induced by the stimulating activity of anti-TSH receptor immunoglobulins. Conventional porcine TSAb and Elecsys thyroid-stimulating hormone receptor antibodies were positive in 69.3 and 95.5% of GD, respectively. Conclusion: The aequorin TSAb assay was positive in 98.9% of GD and was more sensitive than the conventional assay. This assay can be conducted in only 4 h without sterilized conditions and is practically useful in general clinical laboratories.

scholarly journals Atypical Features Resembling Poorly Differentiated Thyroid Carcinoma Presenting Entirely within a Follicular Adenoma

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Daniel Ching ◽  
Connull Leslie
Keyword(s):  
Thyroid Carcinoma ◽  
Unusual Case ◽  
Follicular Adenoma ◽  
Differentiated Thyroid Carcinoma ◽  
Follicular Neoplasm ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Biological Potential ◽  
Poorly Differentiated ◽  
High Mitotic Count ◽  
Widely Invasive

Poorly differentiated thyroid carcinoma (PDTC) is rare and is usually widely invasive at presentation. Here we present an unusual case with a component meeting diagnostic criteria for PDTC by Turin consensus proposal arising within a follicular adenoma. A 44-year-old female was found to have an incidental right thyroid nodule that was suggestive of follicular neoplasm on FNA. Histological examination of hemithyroidectomy revealed an 11 mm focus with insular growth pattern, alteration in cell morphology, and high mitotic count meeting criteria for PDTC. In addition there were several regions showing trabecular architecture with increased mitotic activity but not meeting criteria for PDTC. The literature for such cases is sparse but suggests much better prognosis than conventional invasive PDTC, although a biological potential for aggressive behaviour may be possible.

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