Antitumor Effect of Bleomycin A6 on Human Liver Cancer BEL-7402 Xenografts in Nude Mice

2015 ◽  
pp. 254-257
Author(s):  
Yong-su Zhen ◽  
Min Jiang ◽  
Yu-chuan Xue
Keyword(s):  
Liver Cancer ◽  
Nude Mice ◽  
Human Liver ◽  
Antitumor Effect ◽  
Human Liver Cancer

Effects of pseudofype retrovirus containing human N-RAS antisense gene on the growth of human liver cancer LTNM4 transplanted in nude mice

1991 ◽  
Vol 3 (2) ◽  
pp. 22-26
Author(s):  
Xu Xiulan ◽  
Jia Libin ◽  
Zheng Yahai ◽  
Gan Chen ◽  
Gu Jianren ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Nude Mice ◽  
Human Liver ◽  
Antisense Gene ◽  
Human Liver Cancer

Metastatic models of human liver cancer in nude mice orthotopically constructed by using histologically intact patient specimens

1996 ◽  
Vol 122 (7) ◽  
pp. 397-402 ◽  
Author(s):  
Fan-Xian Sun ◽  
Zhao-You Tang ◽  
Kang-Da Liu ◽  
Oiong Xue ◽  
Dong-Mei Gao ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Nude Mice ◽  
Human Liver ◽  
Human Liver Cancer

scholarly journals EZH2-mediated epigenetic silencing of ZIC4 in hepatocellular carcinoma

2020 ◽  
Author(s):  
Jinghui Wang ◽  
Zhu Yang ◽  
Fengxi Long ◽  
Li Luo ◽  
Gao Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Human Liver ◽  
Antitumor Effect ◽  
Epithelial Mesenchymal Transition ◽  
Epigenetic Silencing ◽  
The Cancer Genome Atlas ◽  
Mesenchymal Transition ◽  
Human Liver Cancer

Abstract Background: The present study aimed to explore the role of ZIC4 in human liver cancer.Methods: Illumina450 genome-wide methylation data was downloaded from The Cancer Genome Atlas for 50 available liver tumor/surrounding pairs. Wound healing test, colony formation and flow cytometry assay were utilized to analyze cell migration, survival and apoptosis. The effects of EZH2 and ZIC4 on tumor growth were also investigated through in vivo xenograft and orthotopic implantation experiments. Results: ZIC4 was hypermethylated in liver cancer tissues and cell lines. EZH2 knockdown and DZNep mediated H3K27me3 contributes to ZIC4 expression. The antitumor effect of EZH2 knockdown on hepatocellular carcinoma growth, metastasis and epithelial-mesenchymal transition progression in vitro were rescued by sh-ZIC4. Downregulation of ZIC4 also rescued the antitumor effect of DZNep in vivo.Conclusions: Epigenetic silencing of ZIC4 by EZH2 mediated H3K27me3 is an important mechanism in human liver cancer and provide a new therapeutic target for the treatment of hepatocellular carcinoma disease.

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