Uraemic Toxins and Blood Purification Strategies

2015 ◽  
pp. 178-187 ◽  
Author(s):  
A. V�lek ◽  
F. Lopot
Keyword(s):  
Blood Purification

Control of Rate of Solute Transport in Newly Developed Portable Agar Gel Blood Purification System

1998 ◽  
Vol 2 (1) ◽  
pp. 67-70
Author(s):  
Akihiro C. Yamashita ◽  
Ryoichi Sakiyama ◽  
Hiroyuki Hamada ◽  
Kakuji J. Tojo
Keyword(s):  
Solute Transport ◽  
Blood Purification ◽  
Agar Gel ◽  
Purification System

Vancomycin Adsorption During in vitro Model of Hemoperfusion with HA380 Cartridge

Nephron ◽  
2021 ◽  
pp. 1-7
Author(s):  
Ilaria Godi ◽  
Anna Lorenzin ◽  
Silvia De Rosa ◽  
Gianlorenzo Golino ◽  
Maira Knust ◽  
...  
Keyword(s):  
Complete Removal ◽  
Potential Interaction ◽  
Blood Purification ◽  
Therapeutic Monitoring ◽  
High Concentration ◽  
Langmuir Isotherm Model ◽  
Vitro Model ◽  
Kinetics Of ◽  
Balanced Solution

<b><i>Introduction:</i></b> A critical point for using blood purification during sepsis may be the potential interaction with antimicrobial therapy, the mainstay of sepsis treatment. The aim of our study was to investigate the vancomycin removal during hemoperfusion (HP) using HA380 cartridge. <b><i>Methods:</i></b> This is an experimental study, in which 500 mL of solution was circulated in a closed-circuit (blood flow of 250 mL/min) simulating HP ran using HA380. Vancomycin was added to reach a through concentration or a very high concentration to evaluate the removal ratio (RR) during 120 min of HP. Comparison between blood-crystalloid solution and balanced solution was performed by using Kruskal-Wallis test. The kinetics of vancomycin removal and the adsorption isotherm were evaluated. <b><i>Results:</i></b> We found a complete removal of vancomycin at baseline through concentration of 23.0 ± 7.4 mg/L. Using extremely high concentration (baseline 777.0 ± 62.2 mg/L), RR was 90.1 ± 0.6% at 5 min and 99.2 ± 0.6% at 120 min. No difference in terms of RR was found between blood-crystalloid mixture and balanced solution. The kinetics of the vancomycin reduction followed an exponential decay. Repeated boluses (total amount of 2,000 mg) resulted in cumulative adsorption of 1,919.4 mg with RR of 96.6 ± 1.4%, regardless of the amount injected (100 vs. 500 mg). Vancomycin adsorption onto HA380 followed the Langmuir isotherm model. <b><i>Conclusions:</i></b> A considerable amount of vancomycin was rapidly removed during in vitro HP with HA380. Clinical studies are needed to determine whether this may lead to underdosing. Drug therapeutic monitoring is highly recommended when using HA380 for blood purification in patients receiving vancomycin.

scholarly journals Integrated management is effective in the prevention and control of COVID-19 in the blood purification center: joint efforts from multiple departments

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jinmei Yin ◽  
Jun Yin ◽  
Zhiwu Tian ◽  
Peiqiu Li ◽  
Xiaoqiu Chen
Keyword(s):  
Medical Staff ◽  
Prevention And Control ◽  
Integrated Management ◽  
Medical Personnel ◽  
Blood Purification ◽  
Medical Department ◽  
Effective Prevention ◽  
Dialysis Center ◽  
Education Of Patients ◽  
And Control

Abstract Background During the outbreak of new coronavirus pneumonia, many hospitals in China became the designated hospitals for the treatment of new coronavirus pneumonia. The goal was to develop rapid and effective prevention and control methods for blood purification centers. Research design and methods The medical department, hospital department, nursing department, and blood purification center jointly set up a multi-department integrated COVID-19 prevention and control management team to manage the blood purification center. The efforts included the establishment of the continuous renal replacement therapy (CRRT) team for COVID-19, the integrated training and assessment of medical personnel, the integrated education of patients and their families, and the integrated management of the workflow of the hemodialysis room. Results No infected persons, including medical staff, patients, and their families, have been found in the dialysis center. After multi-departmental integrated training, the theoretical performance of medical staff in our dialysis center has increased from 82.36 ± 8.10 to 95.29 ± 4.95 (p < 0.05), and the unqualified rate dropped from 23.21 to 1.78% (p < 0.05). In addition, the three operational skills evaluation scores have also been significantly improved, from 86.00 ± 4.02, 88.01 ± 6.20, 92.01 ± 2.46 to 95.90 ± 0.30, 97.21 ± 0.87, 96.00 ± 1.00 (p < 0.01), and the passing rate from 80.36 to 100% (p < 0.05). Conclusion Medical staff’s knowledge of novel coronavirus pneumonia prevention and control can be improved by multi-sectoral integrated management, and CRRT treatment of COVID-19 patients is effective.

Overview of blood purification in uremia

1980 ◽  
Vol 3 (4) ◽  
pp. 203-208
Author(s):  
B.T. Burton
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Renal Transplantation ◽  
Rejection Rate ◽  
Blood Purification ◽  
Maintenance Hemodialysis ◽  
Dialysis Patients ◽  
Transplant Patients ◽  
Maintenance Dialysis ◽  
Transplanted Kidneys

Today, management of irreversible renal failure is based primarily on maintenance hemodialysis and renal transplantation with a growing minority of patients treated by peritoneal dialysis. With regard to renal transplantation — the early promise of renal transplantation in the mid 1960's has given way to the realities of the late 1970's. There have been no major changes in the rejection rate of transplanted kidneys in recent years though today's mortality of transplant patients is considerably reduced over what it used to be. Moreover, universally the lack of availability of a sufficient number of organs for transplantation poses a formidable problem. It is all too apparent that current methods of blood purification in uremia are far from optimal. Even though the mortality in maintenance dialysis is relatively low, hemodialysis is characterized by a variety of complications and most maintenance dialysis patients are not optimally rehabilitated.

scholarly journals Application of Advanced Nanomaterials for Kidney Failure Treatment and Regeneration

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2939
Author(s):  
Aziz Eftekhari ◽  
Solmaz Maleki Dizaj ◽  
Elham Ahmadian ◽  
Agata Przekora ◽  
Seyed Mahdi Hosseiniyan Khatibi ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Material Science ◽  
Human Life ◽  
Renal Tissue ◽  
Blood Purification ◽  
Review Article ◽  
Renal Diseases ◽  
Drug Solubility ◽  
Failure Treatment

The implementation of nanomedicine not only provides enhanced drug solubility and reduced off-target adverse effects, but also offers novel theranostic approaches in clinical practice. The increasing number of studies on the application of nanomaterials in kidney therapies has provided hope in a more efficient strategy for the treatment of renal diseases. The combination of biotechnology, material science and nanotechnology has rapidly gained momentum in the realm of therapeutic medicine. The establishment of the bedrock of this emerging field has been initiated and an exponential progress is observed which might significantly improve the quality of human life. In this context, several approaches based on nanomaterials have been applied in the treatment and regeneration of renal tissue. The presented review article in detail describes novel strategies for renal failure treatment with the use of various nanomaterials (including carbon nanotubes, nanofibrous membranes), mesenchymal stem cells-derived nanovesicles, and nanomaterial-based adsorbents and membranes that are used in wearable blood purification systems and synthetic kidneys.

Blood purification therapy for sepsis

2006 ◽  
Vol 35 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Hiromi Sakata ◽  
Motoki Yonekawa ◽  
Akio Kawamura
Keyword(s):  
Blood Purification ◽  
Blood Purification Therapy
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