Modulation of the Oncogenic Potential of Various Anticancer Modalities1

2015 ◽  
pp. 131-139 ◽  
Author(s):  
Eric J. Hall ◽  
Tom K. Hei ◽  
Richard C. Miller
Keyword(s):  
Oncogenic Potential

scholarly journals Oncogenic Potential of the Dual-Function Protein MEX3A

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 415
Author(s):  
Marcell Lederer ◽  
Simon Müller ◽  
Markus Glaß ◽  
Nadine Bley ◽  
Christian Ihling ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Rna Binding ◽  
Dual Function ◽  
Self Renewal ◽  
Oncogenic Potential ◽  
Protein Ubiquitination ◽  
Domain Composition ◽  
New Gene ◽  
Ligase Function

MEX3A belongs to the MEX3 (Muscle EXcess) protein family consisting of four members (MEX3A-D) in humans. Characteristic for MEX3 proteins is their domain structure with 2 HNRNPK homology (KH) domains mediating RNA binding and a C-terminal really interesting new gene (RING) domain that harbors E3 ligase function. In agreement with their domain composition, MEX3 proteins were reported to modulate both RNA fate and protein ubiquitination. MEX3 paralogs exhibit an oncofetal expression pattern, they are severely downregulated postnatally, and re-expression is observed in various malignancies. Enforced expression of MEX3 proteins in various cancers correlates with poor prognosis, emphasizing their oncogenic potential. The latter is supported by MEX3A’s impact on proliferation, self-renewal as well as migration of tumor cells in vitro and tumor growth in xenograft studies.

scholarly journals Modeling and Molecular Dynamics of the 3D Structure of the HPV16 E7 Protein and Its Variants

2021 ◽  
Vol 22 (3) ◽  
pp. 1400
Author(s):  
Ciresthel Bello-Rios ◽  
Sarita Montaño ◽  
Olga Lilia Garibay-Cerdenares ◽  
Lilian Esmeralda Araujo-Arcos ◽  
Marco Antonio Leyva-Vázquez ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
3D Structure ◽  
Epidemiological Studies ◽  
Dynamics Simulation ◽  
Structural Refinement ◽  
Oncogenic Potential ◽  
Structural Differences ◽  
Reference Protein ◽  
E6 And E7 ◽  
First Time

The oncogenic potential of high-risk human papillomavirus (HPV) is predicated on the production of the E6 and E7 oncoproteins, which are responsible for disrupting the control of the cell cycle. Epidemiological studies have proposed that the presence of the N29S and H51N variants of the HPV16 E7 protein is significantly associated with cervical cancer. It has been suggested that changes in the amino acid sequence of E7 variants may affect the oncoprotein 3D structure; however, this remains uncertain. An analysis of the structural differences of the HPV16 E7 protein and its variants (N29S and H51N) was performed through homology modeling and structural refinement by molecular dynamics simulation. We propose, for the first time, a 3D structure of the E7 reference protein and two of Its variants (N29S and H51N), and conclude that the mutations induced by the variants in N29S and H51N have a significant influence on the 3D structure of the E7 protein of HPV16, which could be related to the oncogenic capacity of this protein.

Original Article: MicroRNA Dysregulation in the Gastric Carcinogenesis Cascade: Can We Anticipate Its Role in Individualized Care?

Pathobiology ◽  
2021 ◽  
pp. 1-13
Author(s):  
Inês Pita ◽  
Diogo Libânio ◽  
Francisca Dias ◽  
Ana Luísa Teixeira ◽  
Inês Nogueira ◽  
...  
Keyword(s):  
Tissue Expression ◽  
Normal Mucosa ◽  
Cross Sectional Study ◽  
Gastric Carcinogenesis ◽  
Endoscopic Biopsy ◽  
Cross Sectional ◽  
Oncogenic Potential ◽  
Individualized Care ◽  
Gastric Neoplasia ◽  
Microrna Dysregulation

<b><i>Background:</i></b> Gastric carcinogenesis progresses from normal mucosa, atrophic/metaplastic gastritis, and dysplasia to adenocarcinoma. MicroRNAs (miRNAs) regulate DNA expression and have been implicated; however, their role is not fully established. <b><i>Aims:</i></b> The aim of this study was to characterize plasma and tissue expression of several miRNAs in gastric carcinogenesis stages. <b><i>Methods:</i></b> Single-center cross-sectional study in 64 patients: 19 controls (normal mucosa); 15 with extensive atrophic/metaplastic gastritis; and 30 with early gastric neoplasia (EGN). Seven miRNAs (miR-21, miR-146a, miR-181b, miR-370, miR-375, miR 181b, and miR-490) were quantified by real time-qPCR in peripheral blood and endoscopic biopsy samples. <b><i>Results:</i></b> We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2–14-times higher than controls). We observed a significant underexpression of miR-146a and miR-370 in atrophic/metaplastic gastritis (86 and 66% decrease, <i>p</i> = 0.008 and <i>p</i> = 0.001) and in EGN (89 and 62% reduction, <i>p</i> = 0.034 and <i>p</i> = 0.032) compared with controls. There were no differences between lesions and nonneoplastic mucosa and no dysregulation of plasma miRNAs. <b><i>Conclusion:</i></b> We found significant dysregulation of 5 miRNAs in gastric carcinogenesis, suggesting a tumor suppressor role for miR-146a and miR-370 and oncogenic potential for miR-21, miR-181, and miR-490. These changes happen diffusely in the gastric mucosa, suggesting a high-risk field defect, which may influence these patients’ surveillance.

Human Papillomavirus in Various Lesions of the Head and Neck

1985 ◽  
Vol 93 (3) ◽  
pp. 342-346 ◽  
Author(s):  
Melvin Strauss ◽  
A. Bennett Jenson
Keyword(s):  
Human Papillomavirus ◽  
Oral Cavity ◽  
Head And Neck ◽  
Adult Onset ◽  
Childhood Onset ◽  
Oncogenic Potential ◽  
Suggestive Evidence ◽  
Malignant Lesions ◽  
Epithelial Lesions

The association of human papillomavirus with benign and malignant epithelial lesions of the head and neck has been studied by a peroxidase-antiperoxidase technique having immunospecificity against genus-specific structural antigens of the papillomaviruses. More than 360 specimen blocks from 144 patients were evaluated. There was evidence of human papillomavirus antigen in three out of eight patients with childhood-onset laryngeal papillomas (37.5%) and in four out of eight patients with adult-onset papillomas (50%). A patient with an unusual flat, wartlike lesion appearing as an oral cavity leukoplakia had detectable papillomavirus antigen in it. None of the 13 cases of inverting papilloma or any of the malignant lesions studied showed evidence for the presence of papillomavirus antigen. There is currently only suggestive evidence for the oncogenic potential of human papillomavirus in the head and neck.

scholarly journals Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.

1992 ◽  
Vol 267 (12) ◽  
pp. 7967-7970
Author(s):  
S.J. Theroux ◽  
C Taglienti-Sian ◽  
N Nair ◽  
J.L. Countaway ◽  
H.L. Robinson ◽  
...  
Keyword(s):  
Phosphorylation Site ◽  
Serine Phosphorylation ◽  
Oncogenic Potential ◽  
Terminal Domain
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