Effects of Nifedipine and Verapamil on Splanchnic and Renal Blood Flow and Function

2015 ◽  
pp. 104-117
Author(s):  
T. Takagia ◽  
M. Kato ◽  
S. Naruse ◽  
S. Shionoya
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
And Function

The effects of pulsatile and non-pulsatile cardiopulmonary bypass on renal blood flow and function

1989 ◽  
Vol 19 (3) ◽  
pp. 334-345 ◽  
Author(s):  
Kunihide Nakamura ◽  
Yasunori Koga ◽  
Ryo Sekiya ◽  
Toshio Onizuka ◽  
Kiyoshi Ishii ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiopulmonary Bypass ◽  
Renal Blood Flow ◽  
And Function

INCREASING TIME OF INTESTINAL ISCHEMIA/REPRFUSION (II/R) DECREASES RENAL BLOOD FLOW AND FUNCTION

Shock ◽  
2006 ◽  
Vol 25 (Supplement 1) ◽  
pp. 23
Author(s):  
L. Wang ◽  
F. Liu ◽  
L. Bartula ◽  
S. Myers
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Intestinal Ischemia ◽  
And Function

Drug-Drug Interactions Between Lithium and Cardiovascular as Well as Anti-Inflammatory Drugs

2020 ◽  
Vol 53 (05) ◽  
pp. 229-234
Author(s):  
Maike Scherf-Clavel ◽  
Susanne Treiber ◽  
Jürgen Deckert ◽  
Stefan Unterecker ◽  
Leif Hommers
Keyword(s):  
Blood Flow ◽  
Renal Function ◽  
Serum Concentration ◽  
Drug Interactions ◽  
Renal Blood Flow ◽  
Serum Levels ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
And Function ◽  
Bipolar Affective Disorders

Abstract Introduction Lithium is the gold standard in treating bipolar affective disorders. As patients become increasingly older, drug-drug interactions leading to decreased excretion of lithium represent a key issue in lithium safety. As no study considered the effect of comedications on lithium serum concentration in combination, we aimed to quantify the impact of drugs affecting renal blood flow and function and thus potentially interacting drugs (diuretics, ACE inhibitors, AT1 antagonists, and non-steroidal anti-inflammatory drugs) on lithium serum levels in addition to age, sex, and sodium and potassium serum levels as well as renal function. Methods Retrospective data of lithium serum levels were analyzed in 501 psychiatric inpatients (2008–2015) by means of linear regression modelling. Results The number of potentially interacting drugs was significantly associated with increasing serum levels of lithium in addition to the established factors of age, renal function, and sodium concentration. Additionally, absolute lithium levels were dependent on sex, with higher values in females. However, only NSAIDs were identified to increase lithium levels independently. Discussion Routine clinical practice needs to focus on drugs affecting renal blood flow and function, especially on NSAIDs as over-the-counter medication that may lead to an increase in lithium serum concentration. To prevent intoxications, clinicians should carefully monitor the comedications, and they should inform patients about possible intoxications due to NSAIDs.

scholarly journals Hepatosplanchnic haemodynamics and renal blood flow and function in rats with liver failure

Gut ◽  
1998 ◽  
Vol 43 (2) ◽  
pp. 272-279 ◽  
Author(s):  
P Javlé ◽  
J Yates ◽  
H G Kynaston ◽  
K F Parsons ◽  
S A Jenkins
Keyword(s):  
Blood Flow ◽  
Liver Function ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Renal Blood Flow ◽  
Portal Pressure ◽  
Renal Haemodynamics ◽  
Aminopyrine Breath Test ◽  
Arterial Blood ◽  
And Function

Background—Massive liver necrosis, characteristic of acute liver failure, may affect hepatosplanchnic haemodynamics, and contribute to the alterations in renal haemodynamics and function.Aims—To investigate the relation between hepatosplanchnic haemodynamics, including portal systemic shunting, and renal blood flow and function in rats with acute liver failure.Methods—Liver failure was induced in male Wistar rats by intraperitoneal injection of 1.1 g/kg ofd(+)-galactosamine hydrochloride. The parameters assessed included: systemic, hepatosplanchnic, and renal blood flow (57Co microsphere method); portal-systemic shunting and intrarenal shunting (consecutive intrasplenic, intraportal, or renal arterial injections of 99mTc methylene diphosphonate and99mTc albumin microspheres); arterial blood pressure and portal pressure; renal function; and liver function (liver function tests and 14C aminopyrine breath test).Results—Progressive liver dysfuntion was accompanied by the development of a hyperdynamic circulation, a highly significant decrease in renal blood flow and function, and an increase in intrarenal shunting 36, 42, and 48 hours after administration of d-galactosamine. The alterations in renal blood flow and function were accompanied by significant increases in portal pressure, portal venous inflow, and intrahepatic portal systemic shunting in galactosamine treated rats compared with controls. There was a significant correlation between changes in renal blood flow and changes in portal pressure, intrahepatic portal systemic shunting, and deterioration in liver function (r=0.8, p<0.0001).Conclusions—The results of this study suggest that both increased intrahepatic portal systemic shunting and hepatocyte impairment may contribute to alterations in renal haemodynamics and function.

Renal blood flow and function during recovery from experimental septic acute kidney injury

2007 ◽  
Vol 33 (9) ◽  
pp. 1614-1618 ◽  
Author(s):  
Christoph Langenberg ◽  
Li Wan ◽  
Moritoki Egi ◽  
Clive N. May ◽  
Rinaldo Bellomo
Keyword(s):  
Acute Kidney Injury ◽  
Blood Flow ◽  
Renal Blood Flow ◽  
Kidney Injury ◽  
Septic Acute Kidney Injury ◽  
And Function
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