EEG and Dementia in Hereditary Cerebral Haemorrhage with Amyloidosis

Inhibitorentwicklung nach früher hoher Exposition und Hirnblutung

Hämostaseologie ◽

10.1055/s-0037-1619091 ◽

2010 ◽

Vol 30 (S 01) ◽

pp. S115-S118

Author(s):

C. Moorthi ◽

A. Bade ◽

C. Niekrens ◽

G. Auerswald ◽

K. Haubold

Keyword(s):

High Titer ◽

Cerebral Haemorrhage ◽

High Dose ◽

Haemophilia A ◽

Severe Haemophilia ◽

Intron 22 Inversion ◽

Neurosurgical Intervention

SummarySevere haemophilia A was diagnosed postpartum in a newborn. The mother was known as a conductor (intron 22 inversion) and an uncle had a persistently high titer inhibitor after failed ITI.Due to a cephalhaematoma, a high-dose pdFVIII substitution was given within the first days after birth. At the age of six month a severe cerebral haemorrhage occurred, making a high-dose pdFVIII substitution and neurosurgical intervention necessary. Several days later a porth-a-cath-system was implanted. The development of a high titer inhibitor occured six days later, an ITI was started according to the Bonn Protocol. Initially rFVIIa was given in addition to the pdFVIII substitution. Seven days after the beginning of treatment the inhibitor was no longer detectable. At monthly intervals the FVIII dosage was reduced until the dosage complied with a prophylaxis in severe haemophilia A.The duration of the ITI was nine months. A total of 30 mg rFVIIa and 276 000 IU pdFVIII were used; costs in total: 280 173.60 Euro.

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ADC-values for prediction of postischaemic secondary cerebral haemorrhage

Aktuelle Neurologie ◽

10.1055/s-2007-988092 ◽

2007 ◽

Vol 34 (S 2) ◽

Author(s):

R Huber ◽

HP Mueller ◽

J Kassubek

Keyword(s):

Cerebral Haemorrhage ◽

Adc Values

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LIPOID PROTEINOSIS AND SPONTANEOUS INTRA-CEREBRAL HAEMORRHAGE A CASE REPORT AND REVIEW OF THE LITERATURE

10.26226/morressier.58e389b3d462b802923848ce ◽

2017 ◽

Author(s):

Aparna Pusalkar

Keyword(s):

Case Report ◽

Cerebral Haemorrhage ◽

Review Of The Literature ◽

Lipoid Proteinosis

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Cerebral Amyloid Angiopathy in Combination with Paroxysmal Atrial Fibrillation

Russian neurological Journal ◽

10.30629/2658-7947-2020-25-4-31-37 ◽

2020 ◽

Vol 25 (4) ◽

pp. 31-37

Author(s):

A. A. Kornilova ◽

O. V. Lagoda ◽

M. M. Tanashyan

Keyword(s):

Atrial Fibrillation ◽

Cerebral Amyloid Angiopathy ◽

Paroxysmal Atrial Fibrillation ◽

Past History ◽

Laboratory Data ◽

Clinical Manifestations ◽

Cerebral Haemorrhage ◽

Exclusion Criterion ◽

Amyloid Angiopathy ◽

Cerebral Amyloid

The present article addresses the definition of cerebral amyloid angiopathy (CAA) and its symptoms based on the analysis of the medical case; the issues of diagnosis and treatment of this pathology are discussed. The Boston criteria, which became the basis for diagnosis, study of clinical manifestations and progression of CAA and approaches to its therapy, are presented. Methods and modes of neuroimaging, including magnetic resonance imaging (MRI), which verify micro cerebral haemorrhage, are described. At the same time, the role and significance of cardiac arrhythmias in the genesis of ischemic stroke are discussed, and scales for assessing the risk of its occurrence are presented. The observation of the neurological, somatic, neuroimaging, neuropsychological status of a 62-year-old patient confirms quite rare combination of probable CAA, paroxysmal atrial fibrillation and repeated hemorrhagic functional apoplexy (FA). The relevance of the case described, is a complex clinical dilemma based on mutually exclusive recommendations for the pharmacological correction of such conditions. It is emphasized that in many multicenter clinical studies on the effectiveness of antithrombotic medication (antiaggregants, anticoagulants) in the treatment and prevention of ischaemic functional apoplexy , an important exclusion criterion is a hemorrhagic stroke in past history (including the multiple changes in haemostasis indicators). Taking into account the obtained clinical and laboratory data in the dynamics, the tactics of treating the described patient were determined. The results of studies related to the treatment of comorbid pathology that should become the subject of the development of a personalized algorithm for managing patients in each specific case, are discussed.

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