Association of Aluminium and Silicon with Neuropathological Changes in the Ageing Brain

2015 ◽  
pp. 140-155 ◽  
Author(s):  
J. Candy ◽  
A. Oakley ◽  
D. Gauvreau ◽  
P. Chalker ◽  
H. Bishop ◽  
...  
Keyword(s):  
Ageing Brain

scholarly journals Amyloid in the ageing brain: New frameworks and perspectives

Aging Brain ◽  
2021 ◽  
Vol 1 ◽  
pp. 100008
Author(s):  
Sally Hunter ◽  
Carol Brayne
Keyword(s):  
Ageing Brain

scholarly journals Physiological and Pathological Ageing of Astrocytes in the Human Brain

2021 ◽  
Author(s):  
Marloes Verkerke ◽  
Elly M. Hol ◽  
Jinte Middeldorp
Keyword(s):  
Risk Factor ◽  
Morphological Changes ◽  
Ion Homeostasis ◽  
Brain Functioning ◽  
Physiological Ageing ◽  
Human Astrocytes ◽  
Age Related ◽  
Technical Issues ◽  
Neuronal Transmission ◽  
Ageing Brain

AbstractAgeing is the greatest risk factor for dementia, although physiological ageing by itself does not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk factor for Alzheimer’s disease and is highly expressed in astrocytes. There are indications that human astrocytes change with age and upon expression of APOE4. As these glial cells maintain water and ion homeostasis in the brain and regulate neuronal transmission, it is likely that age- and APOE4-related changes in astrocytes have a major impact on brain functioning and play a role in age-related diseases. In this review, we will discuss the molecular and morphological changes of human astrocytes in ageing and the contribution of APOE4. We conclude this review with a discussion on technical issues, innovations, and future perspectives on how to gain more knowledge on astrocytes in the human ageing brain.

Normal ageing and the brain

1998 ◽  
Vol 15 (1) ◽  
pp. 26-28
Author(s):  
CS Breathnach
Keyword(s):  
Cerebral Cortex ◽  
Imaging Techniques ◽  
Structure And Function ◽  
Ageing Population ◽  
Cell Shrinkage ◽  
Ageing Processes ◽  
Normal Ageing ◽  
And Function ◽  
Ageing Brain ◽  
The Brain

AbstractInterest in the psychiatric aspects of old age predated the institution of geriatrics as a clinical discipline, but the systematic study of the ageing brain only began in the second half of this century when an ageing population presented a global numerical challenge to society. In the senescent cerebral cortex, though the number of neurons is not reduced, cell shrinkage results in synaptic impoverishment with consequent cognitive impairment. Recent advances in imaging techniques, combined with burgeoning knowledge of neurobiological structure and function, have increased our understanding of the ageing processes in the human brain and permit an optimistic approach in the application of the newer insights into neuropsychology and geriatric psychiatry.

Radiosensitivity of the Ageing Brain

Nature ◽  
1964 ◽  
Vol 202 (4938) ◽  
pp. 1232-1234 ◽  
Author(s):  
ANTONIA VERNADAKIS ◽  
NANCY SHERWOOD ◽  
STANLEY GEEL ◽  
PAOLA S. TIMIRAS
Keyword(s):  
Ageing Brain

The need to unify neuropathological assessments of vascular alterations in the ageing brain

2012 ◽  
Vol 47 (11) ◽  
pp. 825-833 ◽  
Author(s):  
Irina Alafuzoff ◽  
Ellen Gelpi ◽  
Safa Al-Sarraj ◽  
Thomas Arzberger ◽  
Johannes Attems ◽  
...  
Keyword(s):  
Ageing Brain

scholarly journals Cell cycle dynamics of NG2 cells in the postnatal and ageing brain

2009 ◽  
Vol 5 (3-4) ◽  
pp. 57-67 ◽  
Author(s):  
Konstantina Psachoulia ◽  
Francoise Jamen ◽  
Kaylene M. Young ◽  
William D. Richardson
Keyword(s):  
Cell Cycle ◽  
Corpus Callosum ◽  
Biological Significance ◽  
Growth Fraction ◽  
Cell Cycle Time ◽  
Active Population ◽  
Dorsal Telencephalon ◽  
Ng2 Cells ◽  
Cell Cycle Dynamics ◽  
Ageing Brain

Oligodendrocyte precursors (OLPs or ‘NG2 cells’) are abundant in the adult mouse brain, where they continue to proliferate and generate new myelinating oligodendrocytes. By cumulative BrdU labelling, we estimated the cell cycle timeTCand the proportion of NG2 cells that is actively cycling (the growth fraction) at ~ postnatal day 6 (P6), P60, P240 and P540. In the corpus callosum,TCincreased from <2 days at P6 to ~9 days at P60 to ~70 days at P240 and P540. In the cortex,TCincreased from ~2 days to >150 days over the same period. The growth fraction remained relatively invariant at ~50% in both cortex and corpus callosum – that is, similar numbers of mitotically active and inactive NG2 cells co-exist at all ages. Our data imply that a stable population of quiescent NG2 cells appears before the end of the first postnatal week and persists throughout life. The mitotically active population acts as a source of new oligodendrocytes during adulthood, while the biological significance of the quiescent population remains to be determined. We found that the mitotic status of adult NG2 cells is unrelated to their developmental site of origin in the ventral or dorsal telencephalon. We also report that new oligodendrocytes continue to be formed at a slow rate from NG2 cells even after P240 (8 months of age).

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