Early Symptoms of Side Effects due to Aminoglycoside Antibiotics

2015 ◽  
pp. 246-249
Author(s):  
Toyoji Miyoshi
Keyword(s):  
Side Effects ◽  
Aminoglycoside Antibiotics ◽  
Early Symptoms

scholarly journals Study on Streptomycin Level in Raw Milk

2011 ◽  
Vol 68 (2) ◽  
Author(s):  
Dorin TIBULCA ◽  
Mirela JIMBOREAN ◽  
Claudiu Dan SALAGEAN
Keyword(s):  
Antibiotic Resistance ◽  
Side Effects ◽  
Streptomyces Griseus ◽  
Raw Milk ◽  
Aminoglycoside Antibiotics ◽  
Three Components

Streptomycin consists of three components, which are linked together by glycoside bonds, and it belongs to the group of the aminoglycoside antibiotics. Streptomycin is naturally produced by actinobacterium Streptomyces griseus. Therapeutically it is used in the case of streptococcal and enterococcal enteritis. Because of its side effects it is rarely used in human treatment, but has an application in the veterinary area. After the treatment of mastitis in breeding animals, increased values of streptomycin were also recorded in liver, kidney, muscle and milk. Presence of Streptomycins in milk has hygienic and industrial implications. Concerning the industrial aspect the Streptomycin residues are inhibitors for proliferation of the lactic microflora. In terms of hygiene, streptomycin can induce the antibiotic resistance phenomenon

scholarly journals Potentiating aminoglycoside antibiotics to reduce their toxic side effects

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0237948 ◽  
Author(s):  
Christopher R. Rosenberg ◽  
Xin Fang ◽  
Kyle R. Allison
Keyword(s):  
Side Effects ◽  
Aminoglycoside Antibiotics

scholarly journals Inhibition of neural phospholipase D activity by aminoglycoside antibiotics

1991 ◽  
Vol 279 (1) ◽  
pp. 319-321 ◽  
Author(s):  
M Liscovitch ◽  
V Chalifa ◽  
M Danin ◽  
Y Eli
Keyword(s):  
Side Effects ◽  
Rat Brain ◽  
Phospholipase D ◽  
Aminoglycoside Antibiotics ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Brain Membranes ◽  
Rat Brain Membranes ◽  
Isolated Rat

The effects of aminoglycoside antibiotics on phospholipase D (PLD) activity were investigated in permeabilized NG108-15 cells and in isolated rat brain membranes. Neomycin inhibited guanosine 5′-[gamma-thio]triphosphate-stimulated PLD activity in digitonin-permeabilized NG108-15 cells in a concentration-dependent manner (50% inhibition at 100 microM). Neomycin similarly inhibited PLD activity present in rat brain membranes and assayed in vitro with [3H]phosphatidylcholine as substrate (50% inhibition at 65 microM). Other aminoglycosides tested (kanamycin, geneticin and streptomycin) were nearly equipotent inhibitors of rat brain PLD. These results indicate that aminoglycoside antibiotics inhibit phosphatidylcholine-PLD activity with comparable and sometimes greater potency than their well known inhibition of phosphoinositide-phospholipase C. The possibility that PLD inhibition could mediate some of the toxic side effects of aminoglycosides is suggested.

scholarly journals Common Aminoglycosides and Platinum-Based Ototoxic Drugs: Cochlear/Vestibular Side Effects and Incidence

2019 ◽  
Vol 40 (02) ◽  
pp. 104-107 ◽  
Author(s):  
Robert DiSogra
Keyword(s):  
Risk Factors ◽  
Side Effects ◽  
Data Base ◽  
Aminoglycoside Antibiotics ◽  
National Library ◽  
Ototoxic Drugs ◽  
Published Research

AbstractThis is a reference chart that identifies 16 aminoglycoside antibiotics and platinum based drugs that could be cochleotoxic, vestibulotoxic or both. Using the most currently available data from published research from the National Library of Medicine's PubMed data base, incidence figures and risk factors are included in the chart along with the potential of permanence of reversibility of the impairment.

scholarly journals Partha’s covid 19 protocol – A preliminary pilot study in Indian patients

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 990-993
Author(s):  
Parthasarathy S ◽  
Chandramohan T
Keyword(s):  
Viral Load ◽  
Pilot Study ◽  
Side Effects ◽  
Antibody Titre ◽  
Exposure Group ◽  
Social Distancing ◽  
Early Symptoms ◽  
Post Exposure ◽  
Indian Patients

Covid 19 is a pandemic affecting many countries with countless deaths and morbidities. There are many drugs, and immune-boosting nutraceuticals developed to tackle the same. There are no strict guidelines still yet described. We propose a guideline or a protocol termed as Partha’s protocol to counter every type of patient and contacts. In our early preliminary pilot study of 76 patients which included contacts, all were segregated into groups and received the drugs according to the protocol from Categories A to D. The basic strategies like social distancing and face masks continued. We had 19 positive cases and the rest as contacts. There was a need for minimal oxygen in two patients. Otherwise, there was no mortality. Among the contacts, there were only a few people (4 in number ) who turned symptomatic, and none turned swab positive. This protocol seems to look like polypharmacy, but all these drugs were being used for different indications safely for many years. Hence it's unlikely to encounter any significant side effects. We also advise taking antibody titre of IgG in the post-exposure group. If it turns out to be positive, we suggest avoiding repeated quarantine on recurrent exposures. We did not measure viral load as we considered early symptoms with exhaustion as a marker. To wait for evidence and then to tackle contacts and less sick patients may be detrimental to countries like India because of its vast population.

scholarly journals High throughput LSPR and SERS analysis of aminoglycoside antibiotics

The Analyst ◽  
2016 ◽  
Vol 141 (17) ◽  
pp. 5120-5126 ◽  
Author(s):  
Kristy S. McKeating ◽  
Maxime Couture ◽  
Marie-Pier Dinel ◽  
Sylvie Garneau-Tsodikova ◽  
Jean-Francois Masson
Keyword(s):  
Side Effects ◽  
High Throughput ◽  
Aminoglycoside Antibiotics ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Adverse Side Effects

Aminoglycoside antibiotics are used in the treatment of infections caused by Gram-negative bacteria, and are often dispensed only in severe cases due to their adverse side effects.

scholarly journals SIDE EFFECTS MONITORING OF AMINOGLYCOSIDE ANTIBIOTIC IN HOSPITALIZED PATIENTS

2018 ◽  
Vol 10 (1) ◽  
pp. 291 ◽  
Author(s):  
Santi Purna Sari ◽  
Siti Syarah Sartika ◽  
Alfina Rianti
Keyword(s):  
Side Effects ◽  
Aminoglycoside Antibiotic ◽  
Hospitalized Patients ◽  
Aminoglycoside Antibiotics ◽  
Algorithm Analysis ◽  
Inpatient Service ◽  
Drug Side Effects ◽  
Patient Interview ◽  
Naranjo Algorithm ◽  
Prescribing Information

Objective: The aim of this study was to monitor the side effects in patients who received aminoglycoside antibiotics at the inpatient service ofFatmawati Hospital from March to May 2017.Methods: This was an observational study based on data collected through patient interview, prescribing information, and medical records. Datawere collected on all inpatients treated with aminoglycosides during the study period (total sampling method). The Naranjo algorithm was used toassess the causality of the observed effects.Results: The data from 33 patients were evaluated, among whom 14 (42.4%) developed nephrotoxicity and 5 (15.2%) had ototoxicity. Based on theNaranjo algorithm analysis, the five cases of ototoxicity were categorized as probable drug side effects. No correlation was found between any of theside effects and either age (p=0.726) or sex (p=0.620).Conclusion: In this evaluation of the side effects attributable to aminoglycoside antibiotics in hospitalized patients, nephrotoxicity was the mostcommon, followed by ototoxicity. The latter was deemed probable drug-related side effects based on the Naranjo algorithm. Of the other side effects,twice as many were considered probable as those thought to be possible drug side effects. Neither age nor sex was significantly related to the adverseeffects secondary to gentamicin or amikacin.

Gastric Ulcers Produced by Cisplatin

1981 ◽  
Vol 39 ◽  
pp. 582-583
Author(s):  
S.K. Aggarwal ◽  
J. San Antonio
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Side Effects ◽  
Antitumor Agent ◽  
Gastric Ulcers ◽  
Enzyme Cytochemistry ◽  
Intestinal Toxicity ◽  
Ovarian Cancers ◽  
Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

Effects of cisplatin treatment on the rat neurohypophysis

1986 ◽  
Vol 44 ◽  
pp. 122-123
Author(s):  
J.M. Fadool ◽  
P.J. Boyer ◽  
S.K. Aggarwal
Keyword(s):  
Side Effects ◽  
Urine Output ◽  
Morphological Changes ◽  
Limiting Factor ◽  
Antineoplastic Drugs

Cisplatin (CDDP) is currently one of the most valuable antineoplastic drugs available. However, it has severe toxic side effects of which nephrotoxicity is the major dose limiting factor in its use. It induces morphological changes in the kidney with hampered urine output. The present study is an effort to determine the influence of the drug on the neurohypophysis for any antidiuretic effects on the kidney.

Severe Drooling and Treatment With Botulinum Toxin

2012 ◽  
Vol 21 (1) ◽  
pp. 15-21
Author(s):  
Merete Bakke ◽  
Allan Bardow ◽  
Eigild Møller
Keyword(s):  
Botulinum Toxin ◽  
Side Effects ◽  
Health Risk ◽  
Flow Rate ◽  
Clinical Evidence ◽  
Acetylcholine Release ◽  
Psychosocial Problems ◽  
Rate Reduction ◽  
Local Inhibition ◽  
Surgical Treatments

Severe drooling is associated with discomfort and psychosocial problems and may constitute a health risk. A variety of different surgical and non-surgical treatments have been used to diminish drooling, some of them with little or uncertain effect and others more effective but irreversible or with side effects. Based on clinical evidence, injection with botulinum toxin (BTX) into the parotid and submandibular glands is a useful treatment option, because it is local, reversible, and with few side effects, although it has to be repeated. The mechanism of BTX is a local inhibition of acetylcholine release, which diminishes receptor-coupled secretion and results in a flow rate reduction of 25–50% for 2–7 months.

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