What is the Thermogenic Target Organ in Adult Man?

2015 ◽  
pp. 244-254
Author(s):  
A. Astrup
Keyword(s):  
Target Organ

Hepatocyte Alterations in Guinea Pigs FED Polychlorinated Biphenyls (PCBs), Dibenzodioxins (PCDD), AND DIBENZOFURANS (PCDF)

1982 ◽  
Vol 40 ◽  
pp. 56-57
Author(s):  
J. N. Turner ◽  
D. N. Collins
Keyword(s):  
Guinea Pigs ◽  
Room Temperature ◽  
Dose Group ◽  
Methyl Cellulose ◽  
Uranyl Acetate ◽  
Target Organ ◽  
Office Building ◽  
Lead Citrate ◽  
Control Groups ◽  
Cooling Fluid

A fire involving an electric service transformer and its cooling fluid, a mixture of PCBs and chlorinated benzenes, contaminated an office building with a fine soot. Chemical analysis showed PCDDs and PCDFs including the highly toxic tetra isomers. Guinea pigs were chosen as an experimental animal to test the soot's toxicity because of their sensitivity to these compounds, and the liver was examined because it is a target organ. The soot was suspended in 0.75% methyl cellulose and administered in a single dose by gavage at levels of 1,10,100, and 500mgm soot/kgm body weight. Each dose group was composed of 6 males and 6 females. Control groups included 12 (6 male, 6 female) animals fed activated carbon in methyl cellulose, 6 males fed methyl cellulose, and 16 males and 10 females untreated. The guinea pigs were sacrificed at 42 days by suffocation in CO2. Liver samples were immediately immersed and minced in 2% gluteraldehyde in cacadylate buffer at pH 7.4 and 4°C. After overnight fixation, samples were postfixed in 1% OsO4 in cacodylate for 1 hr at room temperature, embedded in epon, sectioned and stained with uranyl acetate and lead citrate.

The human heart – a target organ for estrogens?

1985 ◽  
Vol 110 (1_Suppla) ◽  
pp. S122
Author(s):  
O. BELLMANN ◽  
P. G. KIRCHHOFF ◽  
J. FÉNYES-BELLMANN ◽  
H. WALLER-BAUS ◽  
C. SKIRL ◽  
...  
Keyword(s):  
Human Heart ◽  
Target Organ

ZUR PATHOGENESE DES PSEUDOHYPOPARATHYREOIDISMUS

1960 ◽  
Vol XXXIV (III) ◽  
pp. 399-406 ◽  
Author(s):  
Gerhard Schwarz
Keyword(s):  
Target Organ ◽  
Clinical Feature ◽  
Parathyroid Extract

ABSTRACT A case of pseudohypoparathyroidism with positive Ellsworth-Howard-test is reported. In spite of this result is was possible to confirm by phosphate clearance Albright's hypothesis of non-responding target organ; for parathyroid-extract augmented only phosphate-filtration but not the reabsorption of phosphate, as it is to be expected in hypoparathyroidism. As a clinical feature there is a considerable polyarthrosis.

The Target Organ

1990 ◽  
Vol 2 (1) ◽  
pp. 1-1 ◽  
Author(s):  
Charles Rich
Keyword(s):  
Target Organ

Inflammation and Target Organ Damage in Hypertension With or Without Metabolic Syndrome

2005 ◽  
Vol 12 (3) ◽  
pp. 175
Author(s):  
A. Ferrucci ◽  
S. Sciarretta ◽  
V. Venturelli ◽  
G. M. Ciavarella ◽  
P. De Paolis ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ
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