The Role of the Osteoprotegerin/RANKL/RANK System in Diabetic Vascular Disease

2011 ◽  
Vol 18 (31) ◽  
pp. 4813-4819 ◽  
Author(s):  
P. Grigoropoulou ◽  
I. Eleftheriadou ◽  
C. Zoupas ◽  
N. Tentolouris
Keyword(s):  
Vascular Disease ◽  
Diabetic Vascular Disease ◽  
Rank System

DIABETIC VASCULAR DISEASE

BMJ ◽  
1955 ◽  
Vol 2 (4934) ◽  
pp. 308-308
Author(s):  
T. East
Keyword(s):  
Vascular Disease ◽  
Diabetic Vascular Disease

Antiplatelet Agents In Diabetic Lower Extremity Vascular Disease. A Va Cooperative Study

1981 ◽  
Vol 46 (01) ◽  
pp. 091-091
Author(s):  
J Colwell
Keyword(s):  
Lower Extremity ◽  
Vascular Disease ◽  
Collaborative Study ◽  
Antiplatelet Agents ◽  
Vascular Complication ◽  
Smoking History ◽  
Diabetic Patients ◽  
Vascular Events ◽  
Diabetic Vascular Disease

Peripheral vascular disease is a devastating complication of diabetes mellitus. Post-operative vascular death rates are 10% or more following amputation for gangrene in diabetic patients, and three year mortality approaches 30%. An additional 20-30% of patients require subsequent amputation for diabetic gangrene. In view of these statistics, and because of the postulated role of the blood platelet in diabetic vascular disease, a collaborative study on antiplatelet agents was begun in 10 VA medical centers in 1977. In a double-blinded study, aspirin (325 mg tid) plus dipyridamole (75 mg tid) or placebos are given to adult diabetic males who had suffered a recent amputation for diabetic lower extremity vascular disease. End points are major vascular events after at least 3 years of follow-up.Recruitment of 231 subjects was completed by May, 1980. Baseline characteristics are well matched in both groups. Mean age is 59.6 years, duration of diabetes 12.7 years, smoking history 33.3 pack years, and treatment with insulin 68%. Previous myocardial infarction, congestive heart failure, and/or cerebrovascular disease is present in 17-18% and retinopathy is present in 40% at entry. About 43% have more than one vascular complication at baseline.Mean duration of follow-up is now 18 months. Major vascular events in separate patients are: 40 amputations, 31 deaths, 5 myocardial infarctions. Numerous less serious vascular events have also occurred, as have multiple events in single patients. Therapy has been stopped in 17% of patients, but rarely due to drug side effects. Compliance with therapy has been good.We conclude that this study will provide important new information on the natural history of lower extremity vascular disease in diabetes. It will also provide definitive data about the efficacy of antiplatelet agents in diabetic vascular disease.

Diabetic vascular disease and hypertension

1998 ◽  
Vol 13 (5) ◽  
pp. 298-303 ◽  
Author(s):  
Marwan Hamaty ◽  
Mario Lamberti ◽  
James R. Sowers
Keyword(s):  
Vascular Disease ◽  
Diabetic Vascular Disease
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