Endothelium-Dependent Responses in Human Blood Vessels

2015 ◽  
pp. 43-50
Keyword(s):  
Blood Vessels ◽  
Human Blood

The Distribution of Vasculokinase in Human Blood Vessels

1962 ◽  
Vol 08 (01) ◽  
pp. 096-100
Author(s):  
Marvin Murray ◽  
Robert Johnson
Keyword(s):  
Inferior Vena Cava ◽  
Superior Mesenteric Artery ◽  
Blood Vessels ◽  
Human Blood ◽  
Iliac Artery ◽  
Popliteal Artery ◽  
Mesenteric Artery ◽  
Inferior Vena ◽  
Vena Cava ◽  
High Concentrations

Summary133 blood vessels were evaluated for vasculokinase concentration in the freshly morbid state. High concentrations of activity were found in the aorta, iliac artery, superior mesenteric artery and popliteal artery. Activity was occasionally found in the inferior vena cava and common iliacs veins. Other vessels evaluated had no activity. Evaluation of the data with respect to vas-culokinase activity and atherosclerosis suggests higher levels of vasculokinase in those vessels having atherosclerosis.

scholarly journals An in vivo model allowing continuous observation of human vascular formation in the same animal over time

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yohei Tsukada ◽  
Fumitaka Muramatsu ◽  
Yumiko Hayashi ◽  
Chiaki Inagaki ◽  
Hang Su ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Blood Vessels ◽  
Human Blood ◽  
Molecular Mechanisms ◽  
Human Tumor ◽  
Continuous Observation ◽  
In Vivo Models ◽  
Cranial Window ◽  
Pathological Conditions

AbstractAngiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been generated for this purpose in mice, but it is difficult to translate results from mouse to human blood vessels. To understand human vascular biology and translate findings into human research, we need human blood vessel models to replicate human vascular physiology. Here, we show that human tumor tissue transplantation into a cranial window enables engraftment of human blood vessels in mice. An in vivo imaging technique using two-photon microscopy allows continuous observation of human blood vessels until at least 49 days after tumor transplantation. These human blood vessels make connections with mouse blood vessels as shown by the finding that lectin injected into the mouse tail vein reaches the human blood vessels. Finally, this model revealed that formation and/or maintenance of human blood vessels depends on VEGFR2 signaling. This approach represents a useful tool to study molecular mechanisms of human blood vessel formation and to test effects of drugs that target human blood vessels in vivo to show proof of concept in a preclinical model.

scholarly journals Adenoviral Expression of a Urokinase Receptor–Targeted Protease Inhibitor Inhibits Neointima Formation in Murine and Human Blood Vessels

Circulation ◽  
2001 ◽  
Vol 103 (4) ◽  
pp. 562-569 ◽  
Author(s):  
Paul H. A. Quax ◽  
Martine L. M. Lamfers ◽  
JanWillem H. P. Lardenoye ◽  
Jos M. Grimbergen ◽  
Margreet R. de Vries ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Blood Vessels ◽  
Human Blood ◽  
Urokinase Receptor ◽  
Neointima Formation

Advances in Biodegradable Vascular Stent Materials

2020 ◽  
Vol 987 ◽  
pp. 93-98
Author(s):  
Jun Yan Liu ◽  
Jin Guo Wang ◽  
Yun Hai Yu ◽  
Na Wang
Keyword(s):  
Cell Growth ◽  
Blood Vessels ◽  
Human Blood ◽  
Blood Compatibility ◽  
Clinical Treatment ◽  
Vascular Stent ◽  
Cell Compatibility ◽  
Good Biocompatibility ◽  
Materials Used ◽  
Over Time

Biodegradable vascular stent is mainly made of materials that can be naturally decomposed. After implantation into human blood vessels, the vascular stent can be continuously degraded over time and eventually disappear completely after the treated blood vessels are healed and support from the vascular stent is not needed. The vascular stent materials used in clinic should have good biocompatibility, which mainly involves blood compatibility and cell compatibility. In terms of cell compatibility, the influence of materials on cell growth should be observed. The various biological materials should have good anticoagulant character, so as to reduce the tendency of thrombosis and avoid the occurrence of various risk events in clinical treatment.

Postsynaptic α1- and α2-adrenoceptors in human blood vessels: interactions with exogenous and endogenous catecholamines

1987 ◽  
Vol 17 (2) ◽  
pp. 174-181 ◽  
Author(s):  
K. JIE ◽  
P. VAN BRUMMELEN ◽  
P. VERMEY ◽  
P. B. M. W. M. TIMMERMANS ◽  
P. A. VAN ZWIETEN
Keyword(s):  
Blood Vessels ◽  
Human Blood ◽  
Α2 Adrenoceptors ◽  
Endogenous Catecholamines

scholarly journals Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels

2003 ◽  
Vol 63 (3) ◽  
pp. 1003-1011 ◽  
Author(s):  
Sharon M. Moe ◽  
Danxia Duan ◽  
Brian P. Doehle ◽  
Kalisha D. O'Neill ◽  
Neal X. Chen
Keyword(s):  
Blood Vessels ◽  
Human Blood ◽  
Osteoblast Differentiation ◽  
Differentiation Factor

scholarly journals One-Step Method for Endothelial Cell Isolation from Large Human Blood Vessels Using Fibrin Glue

2000 ◽  
Vol 80 (6) ◽  
pp. 987-989 ◽  
Author(s):  
Ellen B M van Leeuwen ◽  
Grietje Molema ◽  
Koert P de Jong ◽  
Marja J A van Luyn ◽  
Freark Dijk ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Blood Vessels ◽  
Fibrin Glue ◽  
Human Blood ◽  
Cell Isolation ◽  
Step Method ◽  
One Step
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