Screening for Neonatal Alloimmune Thrombocytopenia: An Economic Perspective

2015 ◽  
pp. 140-147 ◽  
Author(s):  
Amiram Gafni ◽  
Victor S. Blanchette
Keyword(s):  
Economic Perspective ◽  
Alloimmune Thrombocytopenia

Neonatal alloimmune thrombocytopenia (NATP) caused by anti-BAKa (HPA-3a) maternal antibody detectable only in reactions with intact platelets

2000 ◽  
Vol 10 (4) ◽  
pp. 329-329
Author(s):  
B. R. Curtis ◽  
J. G. McFarland ◽  
C. R. Harrison ◽  
D. D. Ebert ◽  
R. H. Aster
Keyword(s):  
Maternal Antibody ◽  
Alloimmune Thrombocytopenia

Localization of the Br Polymorphism on a 144 bp Exon of the GPIa Gene and Its Application in Platelet DNA Typing

1994 ◽  
Vol 71 (05) ◽  
pp. 651-654 ◽  
Author(s):  
Rainer Kalb ◽  
Sentot Santoso ◽  
Katja Unkelbach ◽  
Volker Kiefel ◽  
Christian Mueller-Eckhardt
Keyword(s):  
Genomic Organization ◽  
Fragment Length Polymorphism ◽  
Human Platelet ◽  
Dna Typing ◽  
Rflp Analysis ◽  
Serological Typing ◽  
Allele Specific ◽  
Polymerase Chain ◽  
Alloimmune Thrombocytopenia ◽  
Rflp Typing

SummaryAlloimmunization against the human platelet alloantigen system Br (HPA-5) is the second most common cause of neonatal alloimmune thrombocytopenia (NAIT) in Caucasian populations. We have recently shown that a single base polymorphism at position 1648 on platelet mRNA coding for GPIa results in an aminoacid substitution at position 505 on the mature GPIa which is associated with the two serological defined Br phenotypes.Since DNA-typing of platelet alloantigens offers possibilities for useful clinical applications, we designed genomic DNA-based restriction fragment length polymorphism (RFLP) typing for Br alloantigens. To establish this technique we analyzed the genomic organization of GPIa adjacent to the polymorphic base. Using the polymerase chain reaction (PCR) of blood cell DNA we have identified two introns (approximately 1.7 and 1.9 kb) flanking a 144 bp coding sequence of the GPIa gene encompassing the polymorphic base 1648. Based on the in- tron sequence, a PCR primer was constructed to amplify a 274 bp fragment which was used for allele-specific RFLP to determine the Br genotypes. The results of RFLP analysis using Mnll endonuclease obtained from 15 donors (2 Br37*, 2 Br^ and 11 Brb/b) correlate perfectly with serological typing by monoclonal antibody-specific immobilization of platelet antigens (MAIPA) assay.

A Socio-economic Perspective on the Urbanisation of Zaatari Camp in Jordan

2015 ◽  
Vol 12 (3) ◽  
pp. 263-278 ◽  
Author(s):  
Ayham Dalal
Keyword(s):  
Financial Aid ◽  
Humanitarian Aid ◽  
Refugee Camps ◽  
Economic Perspective ◽  
Social Spaces ◽  
Economic Dynamics ◽  
Self Reliance ◽  
Durable Solutions

Camps are temporal spaces where refugees are provided with humanitarian aid until durable solutions are made possible. During this period of ‘endless waiting’, these camps are planned to be economically self-contained. However, through time, refugee camps tend to urbanise: their initial empty spaces transform into vibrant markets, habitats and social spaces. In response to this ‘unexpected’ - and sometimes ‘unwanted’ - process, the economically self-contained system of camps breaks. This paper looks into the emerging socio-economic dynamics in Zaatari camp in Jordan, on the light of its urbanisation process and the Jordanian economy. It first explains the how humanitarian aid is provided, and then shows how and why, refugees use it to diversify the economy of the camp. The findings of this paper are then articulated on the existing policies to reduce the financial aid such as ‘self-reliance’ and ‘development’.

Overseas Development Administration. A Guide to Social Analysis for Projects in Developing Countries. London: HMSO. 1995. viii+248 pages. Hardbound. £18.95.

1996 ◽  
Vol 35 (2) ◽  
pp. 189-190
Author(s):  
Mir Annice Mahmood
Keyword(s):  
Developing Countries ◽  
Social Change ◽  
Practical Experience ◽  
Development Projects ◽  
Social Analysis ◽  
Economic Perspective ◽  
Human Environment ◽  
The Past ◽  
The Impact ◽  
Overseas Development

This book, hereinafter referred to as the Guide, has been developed for those social analysts (e.g., anthropologists, sociologists, and human geographers) who have had little or no practical experience in applying their knowledge as development practitioners. In the past, development projects would be analysed from a narrow financial and economic perspective. But with the evolution of thinking on development, this narrow financial and economic aspect has now been broadened to include the impact on society as the very meaning of development has now come to symbolise social change. Thus, development is not restricted only to plans and figures; the human environment in its entirety is now considered for analysis while designing and implementing development projects.

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