Clinical Significance of IgA Class Antiendomysial Antibodies (IgA-EmA) in Dermatitis Herpetiformis and Celiac Disease: Latent Enteropathy in Healthy Relatives Detected by IgA-EmA Tests

2015 ◽  
pp. 471-474
Author(s):  
Tadeusz P. Chorzelski ◽  
Ernst H. Beutner ◽  
Vijay Kumar ◽  
Jadwiga Sulej ◽  
Anita Lutowiecka-Wranicz ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Clinical Significance ◽  
Dermatitis Herpetiformis ◽  
Antiendomysial Antibodies

scholarly journals Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 156 ◽  
Author(s):  
Mónica Villanueva ◽  
Amaya Oyarzún ◽  
Bárbara Leyton ◽  
Mónica González ◽  
Elizabeth Navarro ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Nutritional Status ◽  
Gastrointestinal Symptoms ◽  
Failure To Thrive ◽  
Age At Diagnosis ◽  
Pediatric Hospitals ◽  
Geographical Variations ◽  
Number Of Patients ◽  
Antiendomysial Antibodies

The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight/obesity, but it is unclear how frequent this is and to what extent undernutrition remains a concern. This is relevant because CD tends to be overlooked in overweight patients. With this in mind, we assessed age at diagnosis, clinical characteristics and nutritional status of 155 celiac patients diagnosed between 1994–2017 in four pediatric hospitals in Santiago, Chile. Since 2003, the number of patients diagnosed has increased (p < 0.0033), coinciding with antitransglutaminase and antiendomysial antibodies becoming available to public health systems. In 2000, 4.5% of patients were asymptomatic at diagnosis, suggesting that active search is not routinely applied. Gastrointestinal symptoms plus failure to thrive were significantly more frequent under 2 years (p = 0.0001). Nutritional status has improved at diagnosis and during follow up, but undernutrition remains more frequent in children <2 and <5 years (p < 0.002 and p < 0.0036, respectively). Overweight at diagnosis was reported in 2002 and obesity in 2010. After initiating treatment, since 2010, patients changing from undernourishment to overweight has sometimes been observed after only 6 months on a gluten-free diet.

scholarly journals Overall and Cause-Specific Mortality in Adult Celiac Disease and Dermatitis Herpetiformis Diagnosed in the 21st Century

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Inka Koskinen ◽  
Lauri J. Virta ◽  
Heini Huhtala ◽  
Tuire Ilus ◽  
Katri Kaukinen ◽  
...  
Keyword(s):  
Celiac Disease ◽  
21St Century ◽  
Dermatitis Herpetiformis ◽  
Adult Celiac Disease ◽  
Specific Mortality

scholarly journals Occult Celiac Disease Associated with Lymphocytic Sclerosing Cholangitis

1994 ◽  
Vol 8 (4) ◽  
pp. 249-252 ◽  
Author(s):  
Hugh J Freeman ◽  
WC Peter Kwan
Keyword(s):  
Celiac Disease ◽  
Sclerosing Cholangitis ◽  
Dermatitis Herpetiformis ◽  
Inguinal Lymph Node ◽  
Portal Tract ◽  
Pathological Process ◽  
Gluten Free ◽  
Antimitochondrial Antibodies ◽  
Radiological Features ◽  
Previously Treated

A 60-year-old male with dermatitis herpetiformis and a previously treated lymphoma involving an inguinal lymph node developed abnormal liver chemistry tests. Because of intermittent diarrhea, additional studies revealed lymphocytic colitis and occult celiac disease that responded to a gluten-free diet. A liver biopsy done to explore persistently abnormal liver chemistry tests showed a portal tract-centred inflammatory process characterized by biliary ductal proliferation, epithelial lymphocytosis and concentric lamellar fibrosis. Quantitation of immunoglobulins was normal and antimitochondrial antibodies were negative. Retrograde cholangiograms showed radiological features typical of primary sclerosing cholangius. The epithelial lymphocycosis reported in gastric, small and large intestinal mucosa of some patients with celiac disease may also be present in the biliary ductal columnar epithelium. This report provides additional evidence that celiac disease may be a far more extensive pathological process.

W1288 Anti-Epidermal Transglutaminase (Tge) IgA in Dermatitis Herpetiformis and Pediatric Celiac Disease

2008 ◽  
Vol 134 (4) ◽  
pp. A-672-A-673
Author(s):  
Troy D. Jaskowski ◽  
Tracy Hamblin ◽  
Harry R. Hill ◽  
John J. Zone ◽  
Linda Book ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Epidermal Transglutaminase

Extraintestinal Manifestations of Celiac Disease

2015 ◽  
Vol 33 (2) ◽  
pp. 147-154 ◽  
Author(s):  
María Inés Pinto-Sánchez ◽  
Premysl Bercik ◽  
Elena F. Verdu ◽  
Julio C. Bai
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
High Risk ◽  
Dermatitis Herpetiformis ◽  
Gastrointestinal Symptoms ◽  
Iga Deficiency ◽  
Case Finding ◽  
Aggressive Approach ◽  
Wide Range

Case finding for celiac disease (CD) is becoming increasingly common practice and is conducted in a wide range of clinical situations ranging from the presence of gastrointestinal symptoms to failure to thrive in children, prolonged fatigue, unexpected weight loss and anemia. Case finding is also performed in associated conditions, such as autoimmune thyroid disease, dermatitis herpetiformis and type 1 diabetes, as well as in patients with irritable bowel syndrome, unexplained neuropsychiatric disorders and first-degree relatives of patients with diagnosed CD. This aggressive active case finding has dramatically changed the clinical characteristics of newly diagnosed patients. For instance, higher numbers of patients who present with extraintestinal symptoms are now being diagnosed with CD. Current recommendations state that due to a high risk for complications if the disease remains undiagnosed, patients with extraintestinal symptoms due to CD require appropriate diagnosis and treatment. Despite criticism regarding the cost-effectiveness of case finding in CD, such an aggressive approach has been considered cost-effective for high-risk patients. The diagnosis of CD among patients with extraintestinal symptoms requires a high degree of awareness of the clinical conditions that carry a high risk for underlying CD. Also, understanding the correct use of specific serology and duodenal histology is key for an appropriate diagnostic approach. Both procedures combined are able to confirm diagnosis in the vast majority of cases. However, in certain circumstances, serology and even duodenal histology cannot confirm or rule out CD. A common cause of negative IgA serology is IgA deficiency. For such eventuality, IgG-based serological tests can help confirm the diagnosis. Importantly, some histologically diagnosed cases still remain seronegative despite exclusion of IgA deficiency. On the other hand, duodenal histology may be normal despite the presence of CD-specific antibodies and active CD. This has been clearly demonstrated in some cases of untreated dermatitis herpetiformis, but may also be due to the patchy condition of CD or lesions that are not adequately recognized by nonexpert endoscopists and/or pathologists. The effectiveness of agluten-free diet depends on the clinical end point addressed. A good example is the outcome of bone loss. While risk for fracture normalizes after the first year of dietary treatment, bone parameters measured by densitometry may not be normalized in the long-term follow-up. Moreover, it is still unclear how far an early gluten-free diet will positively affect associated autoimmune diseases like type 1 diabetes and autoimmune thyroiditis.

Correlation Between IgA Antiendomysial Antibodies and Subtotal Villous Atrophy in Dermatitis Herpetiformis

1992 ◽  
Vol 14 (4) ◽  
pp. 298-301 ◽  
Author(s):  
Umberto Volta ◽  
Nicolino Molinaro ◽  
Roberto De Franchis ◽  
Laura Forzenigo ◽  
Marina Landoni ◽  
...  
Keyword(s):  
Dermatitis Herpetiformis ◽  
Villous Atrophy ◽  
Antiendomysial Antibodies

Novel Screening Assay Performance in Pediatric Celiac Disease and Adult Dermatitis Herpetiformis

2010 ◽  
Vol 51 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Troy D Jaskowski ◽  
Matthew R Donaldson ◽  
Christopher M Hull ◽  
Andrew R Wilson ◽  
Harry R Hill ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Screening Assay ◽  
Assay Performance
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