Immunobiological and Chemical Studies on Forssman Antigen-Antibody in Animal and Human Tumors

2015 ◽  
pp. 437-440
Author(s):  
Tsuneatsu Mori
Keyword(s):  
Human Tumors ◽  
Forssman Antigen ◽  
Chemical Studies ◽  
Antigen Antibody

scholarly journals QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN

1941 ◽  
Vol 73 (6) ◽  
pp. 695-709 ◽  
Author(s):  
Michael Heidelberger ◽  
Alfred J. Weil ◽  
Henry P. Treffers
Keyword(s):  
Methods Of Analysis ◽  
Chemical Studies ◽  
Antigen Antibody ◽  
Quantitative Chemical

1. The molecular quantities of hemolysin and complement combining component or components (C'1) involved in hemolysis have been calculated on the basis of new, quantitative, absolute methods of analysis. 2. Molecular combining ratios between antigen, antibody, and C'1 have been established. 3. The data are shown to be in accord with the theory of combination of multivalent antigen with multivalent antibody. 4. The fixation of complement by antigen-antibody combination is qualitatively and quantitatively accounted for on this basis.

scholarly journals AN HETEROPHILE FACTOR IN RAGWEED POLLEN

1940 ◽  
Vol 71 (5) ◽  
pp. 591-601 ◽  
Author(s):  
F. Eastty Sammis
Keyword(s):  
Blood Groups ◽  
Ragweed Pollen ◽  
Rabbit Serum ◽  
Total N ◽  
Heat Stable ◽  
Heat Labile ◽  
Forssman Antigen ◽  
Zones Of Inhibition ◽  
Antigen Antibody ◽  
Antibody Mixture

1. There is serological evidence that ragweed pollen antigen contains a factor which causes an increased hemolysin titre for sheep cells, when injected into rabbits. 2. It remains questionable whether the antigen absorbs normal rabbit hemolysins. It does, however, absorb anti-ragweed hemolysins, as demonstrated by hemolysis inhibition test. 3. Dilution and lyophilization (Mudd-Flosdorf method) of antigen-antibody mixture shows that one hemolytic unit of anti-ragweed rabbit serum combines with 0.00007 mg. of low ragweed total N. There were three zones of inhibition of hemolysis demonstrated. 4. The immune hemolysins are completely absorbed by sheep cells and by Forssman antigen, but not by human cells of groups A or B. 5. Although Forssman antigen was able to absorb anti-ragweed hemolysin, the ragweed antigen was not able to absorb Forssman antibody. 6. Human ragweed sensitive sera from 22 cases with hay fever, before treatment, did not show increased titre of heat-labile or heat-stable hemolysin. There was no change after treatment. 7. Among the human cases there were encountered blood groups A, B, and O. Heat-labile hemolysins for sheep cells were present in nineteen of the twenty-two sera regardless of blood groups.

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