Protein Intake and Deterioration of Renal Function in Rats: Experimental Data and Hypothetical Mechanism1

2015 ◽  
pp. 135-151 ◽  
Author(s):  
C. Kleinknecht ◽  
D. Laouari ◽  
N. Hinglais
Keyword(s):  
Experimental Data ◽  
Renal Function ◽  
Protein Intake

Effect on renal function of change from high to moderate protein intake in type I diabetic patients

Diabetes ◽  
1987 ◽  
Vol 36 (1) ◽  
pp. 73-79 ◽  
Author(s):  
W. L. Kupin ◽  
P. Cortes ◽  
F. Dumler ◽  
C. S. Feldkamp ◽  
M. C. Kilates ◽  
...  
Keyword(s):  
Renal Function ◽  
Protein Intake ◽  
Diabetic Patients ◽  
Type I

scholarly journals High Protein Intake Associates with Cardiovascular Events but not with Loss of Renal Function

2009 ◽  
Vol 20 (8) ◽  
pp. 1797-1804 ◽  
Author(s):  
Nynke Halbesma ◽  
Stephan J.L. Bakker ◽  
Desiree F. Jansen ◽  
Ronald P. Stolk ◽  
Dick De Zeeuw ◽  
...  
Keyword(s):  
Renal Function ◽  
Protein Intake ◽  
Cardiovascular Events ◽  
High Protein ◽  
High Protein Intake

scholarly journals 1580 EFFECT OF PROTEIN INTAKE ON RENAL FUNCTION IN THE DIABETIC MOUSE

1985 ◽  
Vol 19 (4) ◽  
pp. 374A-374A
Author(s):  
Ben H Brouhard ◽  
Lavenla Lagrone
Keyword(s):  
Renal Function ◽  
Protein Intake ◽  
Diabetic Mouse

Do Regular High Protein Diets Have Potential Health Risks on Kidney Function in Athletes?

2000 ◽  
Vol 10 (1) ◽  
pp. 28-38 ◽  
Author(s):  
Jacques R. Poortmans ◽  
Olivier Dellalieux
Keyword(s):  
Renal Function ◽  
Kidney Function ◽  
Protein Intake ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
High Protein ◽  
Calcium Excretion ◽  
Potential Health ◽  
High Protein Intake ◽  
Amino Acid Intake

Excess protein and amino acid intake have been recognized as hazardous potential implications for kidney function, leading to progressive impairment of this organ. It has been suggested in the literature, without clear evidence, that high protein intake by athletes has no harmful consequences on renal function. This study investigated body-builders (BB) and other well-trained athletes (OA) with high and medium protein intake, respectively, in order to shed light on this issue. The athletes underwent a 7-day nutrition record analysis as well as blood sample and urine collection to determine the potential renal consequences of a high protein intake. The data revealed that despite higher plasma concentration of uric acid and calcium. Group BB had renal clearances of creatinine, urea, and albumin that were within the normal range. The nitrogen balance for both groups became positive when daily protein intake exceeded 1.26 g · kg−1 but there were no correlations between protein intake and creatinine clearance, albumin excretion rate, and calcium excretion rate. To conclude, it appears that protein intake under 2.8 g·kg−1 does not impair renal function in well-trained athletes as indicated by the measures of renal function used in this study.

Renal effects of prolonged high protein intake and COX2 inhibition on hypertensive rats with altered renal development

2011 ◽  
Vol 301 (2) ◽  
pp. F327-F333 ◽  
Author(s):  
Virginia Reverte ◽  
Antonio Tapia ◽  
Juan Manuel Moreno ◽  
Leocadio Rodríguez ◽  
Francisco Salazar ◽  
...  
Keyword(s):  
Renal Function ◽  
Protein Intake ◽  
High Protein ◽  
Renal Development ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
High Protein Intake ◽  
Renal Vasoconstriction ◽  
Renal Ablation

Cyclooxygenase 2 (COX2) is involved in regulating renal hemodynamics after renal ablation. It is also known that high protein intake (HPI) leads to a deterioration of renal function when there is preexisting renal disease and that there are important gender differences in the regulation of renal function. This study tested the hypothesis that the role of COX2 in regulating renal function and the renal hemodynamic effects elicited by HPI are enhanced when nephrogenesis is altered during renal development. It was also expected that the role of COX2 and the effects elicited by HPI are age and sex dependent. Newborn Sprague-Dawley rats were treated with an AT1 ANG II receptor antagonist during the nephrogenic period (ARAnp). Experiments were performed at 3–4 and 10–11 mo of age. Arterial pressure was elevated ( P < 0.05) at both ages and in both sexes of ARAnp-treated rats. Renal COX2 expression was only elevated ( P < 0.05) at 10–11 mo of age in both sexes of ARAnp-treated rats. COX2 inhibition induced greater renal vasoconstriction in male and female hypertensive than in normotensive rats at both ages. HPI did not induce glomerular filtration rate (GFR) in the youngest hypertensive rats and in the oldest female hypertensive rats. However, the GFR decreased during HPI (0.63 ± 0.07 to 0.19 ± 0.05 ml/min) in the oldest male hypertensive rats. The HPI-induced increment in proteinuria was greater ( P < 0.05) in male (99 ± 22 mg/day) than in female (30 ± 8 mg/day) hypertensive rats. These results show that COX2 plays an important role in the regulation of renal function when renal development is altered and that prolonged HPI can lead to a renal insufficiency in males but not in females with reduced nephron endowment.

The Effect of a High Protein Intake on Renal Function of Patients with Chronic Renal Insufficiency

Nephron ◽  
1987 ◽  
Vol 47 (1) ◽  
pp. 1-6 ◽  
Author(s):  
G.H. Schaap ◽  
H.J.G. Bilo ◽  
T.H.R. Alferink ◽  
P.L. Oe ◽  
A.J.M. Donker
Keyword(s):  
Renal Function ◽  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Protein Intake ◽  
High Protein ◽  
High Protein Intake

Effect on Renal Function of Change From High to Moderate Protein Intake in Type I Diabetic Patients

Diabetes ◽  
1987 ◽  
Vol 36 (1) ◽  
pp. 73-79 ◽  
Author(s):  
W. L. Kupin ◽  
P. Cortes ◽  
F. Dumler ◽  
C. S. Feldkamp ◽  
M. C. Kilates ◽  
...  
Keyword(s):  
Renal Function ◽  
Protein Intake ◽  
Diabetic Patients ◽  
Type I

scholarly journals Perspectives Concerning the Influence of Protein Intake for Renal Function in Diabetic Nephropathy

2021 ◽  
Vol 3 (1) ◽  
pp. 7-10
Author(s):  
Kato Y ◽  
Kato Y ◽  
Bando H
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Protein Intake ◽  
Filtration Rate ◽  
Diabetic Kidney Disease ◽  
American Diabetes Association ◽  
Estimated Glomerular Filtration Rate ◽  
Protein Restriction ◽  
The Relationship

Regarding the diet treatment of diabetic nephropathy, protein restriction has been recommended. American Diabetes Association (ADA) proposed protein restriction guidelines in the 2008 edition. However, this comment was deleted in the 2013/2019 edition, because of insufficient evidence. A recent report showed that the intake of plant protein has a protective effect on the decrease of estimated glomerular filtration rate (eGFR), and the intake of animal protein has neither protection nor deterioration. There are controversies about the relationship between protein intake and the reduction of renal function. Further research will be expected for diabetic nephropathy, diabetic kidney disease (DKD), and chronic kidney disease (CKD).

Dietary plant and animal protein intake and decline in estimated glomerular filtration rate among elderly women: a 10-year longitudinal cohort study

2020 ◽  
Author(s):  
Amélie Bernier-Jean ◽  
Richard L Prince ◽  
Joshua R Lewis ◽  
Jonathan C Craig ◽  
Jonathan M Hodgson ◽  
...  
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Older Women ◽  
Kidney Function ◽  
Protein Intake ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Animal Protein ◽  
Age Related

Abstract Background Many older women demonstrate an age-related accelerating rate of renal decline that is associated with increased rates of bone disease, cardiovascular disease and mortality. Population-based protein restriction has been studied principally in patients with reduced renal function. In this investigation, we examined the hypothesis of a differential effect of plant-derived protein compared with animal-derived protein on renal function in older women. Methods We assessed dietary intake from a validated food frequency questionnaire and the estimated glomerular filtration rate (eGFR) (using the Chronic Kidney Disease Epidemiology Collaboration creatinine and cystatin C equation) at baseline, 5 and 10 years in the Longitudinal Study of Aging Women cohort. We tested the association between plant- and animal-sourced protein intake and kidney function using linear mixed modeling. Results A total of 1374 Caucasian women [mean (standard deviation, SD) age = 75 years (2.7) and mean (SD) baseline eGFR = 65.6 mL/min/1.73 m2 (13.1)] contributed to the analysis. The average decline in eGFR was 0.64 mL/min/1.73 m2/year [95% confidence interval (CI) 0.56–0.72]. Higher intakes of plant-sourced protein were associated with slower declines in eGFR after adjusting for covariates including animal protein and energy intake (P = 0.03). For each 10 g of plant protein, the yearly decline in eGFR was reduced by 0.12 mL/min/1.73 m2 (95% CI 0.01–0.23), principally associated with fruit-, vegetable- and nut-derived protein. The intake of animal protein was not associated with eGFR decline (P = 0.84). Conclusions Older women consuming a diet that is richer in plant-sourced protein have a slower decline in kidney function. These data extend support for the health benefits of plant-rich diets in the general population to maintain kidney health.

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