Slime Production by Coagulase Negative Staphylococci � a Major Virulence Factor?

2015 ◽  
pp. 79-84 ◽  
Author(s):  
Karl G. Kristinsson ◽  
Robert C. Spencer ◽  
J. G. Mark Hastings ◽  
Colin B. Brown
Keyword(s):  
Virulence Factor ◽  
Coagulase Negative Staphylococci ◽  
Major Virulence Factor ◽  
Slime Production

Usefulness of a Test for Slime Production as a Marker for Clinically Significant Infections with Coagulase-Negative Staphylococci

1986 ◽  
Vol 153 (2) ◽  
pp. 332-339 ◽  
Author(s):  
D. S. Davenport ◽  
R. M. Massanari ◽  
M. A. Pfaller ◽  
M. J. Bale ◽  
S. A. Streed ◽  
...  
Keyword(s):  
Coagulase Negative Staphylococci ◽  
Slime Production ◽  
Clinically Significant

scholarly journals TcsL Is an Essential Virulence Factor inClostridium sordelliiATCC 9714

2011 ◽  
Vol 79 (3) ◽  
pp. 1025-1032 ◽  
Author(s):  
Glen P. Carter ◽  
Milena M. Awad ◽  
Yibai Hao ◽  
Tennille Thelen ◽  
Ingrid L. Bergin ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Virulence Factor ◽  
Reference Strain ◽  
Molecular Level ◽  
Mortality Rates ◽  
The Other ◽  
Strain Atcc ◽  
Human Pathogen ◽  
Uterine Infection ◽  
Major Virulence Factor

ABSTRACTClostridium sordelliiis an important pathogen of humans and animals, causing a range of diseases, including myonecrosis, sepsis, and shock. Although relatively rare in humans, the incidence of disease is increasing, and it is associated with high mortality rates, approaching 70%. Currently, very little is known about the pathogenesis ofC. sordelliiinfections or disease. Previous work suggested that the lethal large clostridial glucosylating toxin TcsL is the major virulence factor, but a lack of genetic tools has hindered our ability to conclusively assign a role for TcsL or, indeed, any of the other putative virulence factors produced by this organism. In this study, we have developed methods for the introduction of plasmids intoC. sordelliiusing RP4-mediated conjugation fromEscherichia coliand have successfully used these techniques to insertionally inactivate thetcsLgene in the reference strain ATCC 9714, using targetron technology. Virulence testing revealed that the production of TcsL is essential for the development of lethal infections byC. sordelliiATCC 9714 and also contributes significantly to edema seen during uterine infection. This study represents the first definitive identification of a virulence factor inC. sordelliiand opens the way for in-depth studies of this important human pathogen at the molecular level.

scholarly journals Structure and Mechanism of Cysteine Peptidase Gingipain K (Kgp), a Major Virulence Factor ofPorphyromonas gingivalisin Periodontitis

2014 ◽  
Vol 289 (46) ◽  
pp. 32291-32302 ◽  
Author(s):  
Iñaki de Diego ◽  
Florian Veillard ◽  
Maryta N. Sztukowska ◽  
Tibisay Guevara ◽  
Barbara Potempa ◽  
...  
Keyword(s):  
Virulence Factor ◽  
Cysteine Peptidase ◽  
Major Virulence Factor

Neuraminidase produces dose-dependent decrease of slime production and adherence of slime-forming, coagulase-negative staphylococci

2004 ◽  
Vol 35 (4) ◽  
pp. 275-278 ◽  
Author(s):  
Serhan Sakarya ◽  
Serkan Oncu ◽  
Selcen Oncu ◽  
Barcin Ozturk ◽  
Gunay Tuncer ◽  
...  
Keyword(s):  
Coagulase Negative Staphylococci ◽  
Slime Production ◽  
Dose Dependent Decrease ◽  
Dose Dependent
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