Action of Corticotropin-Releasing Factor on the Nervous System

2015 ◽  
pp. 58-78
Author(s):  
M�ty�s Fekete ◽  
M�ria Sz�nt�-Fekete ◽  
Gyula Telegdy
Keyword(s):  
Nervous System ◽  
Corticotropin Releasing Factor

Effect of a central CRF antagonist on cardiovascular and thermoregulatory responses induced by stress or IL-1 beta

1993 ◽  
Vol 265 (4) ◽  
pp. R834-R839 ◽  
Author(s):  
T. Nakamori ◽  
A. Morimoto ◽  
N. Murakami
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Interleukin 1 ◽  
Corticotropin Releasing Factor ◽  
Mild Stress ◽  
Induced Responses ◽  
Interleukin 1 Beta ◽  
The Central Nervous System ◽  
Beta 2

We investigated the role of central corticotropin-releasing factor (CRF) in the development of cardiovascular and thermal responses induced by stress or by interleukin-1 beta (IL-1 beta) in free-moving rats. Intracerebroventricular (icv) injection of alpha-helical CRF9-41 (10 micrograms), a CRF receptor antagonist, significantly attenuated hypertension, tachycardia, and a rise in body temperature induced by cage-switch stress, a mild stress. However, icv injection of alpha-helical CRF9-41 (10 micrograms) had no effect on hypertension, tachycardia, or fever induced by intraperitoneal (ip) injection of IL-1 beta (2 micrograms/kg) or icv prostaglandin E2 (PGE2, 100 ng). In contrast, icv injection of alpha-helical CRF9-41 (10 micrograms) significantly attenuated hypertension, tachycardia, or fever induced by icv injection of IL-1 beta (20 ng). The present results suggest that central CRF has an important role in the development of the cage-switch stress-induced responses, but it does not seem to contribute to the hypertension, tachycardia, and fever induced by ip IL-1 beta or by central PGE2. However, it is possible that when IL-1 beta directly acts on the central nervous system, some of its actions are mediated by central CRF.

Corticotropin-Releasing Factor: Actions on the Sympathetic Nervous System and Metabolism*

Endocrinology ◽  
1982 ◽  
Vol 111 (3) ◽  
pp. 928-931 ◽  
Author(s):  
MARVIN R. BROWN ◽  
LAUREL A. FISHER ◽  
JOACHIM SPIESS ◽  
CATHERINE RIVIER ◽  
JEAN RIVIER ◽  
...  
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Corticotropin Releasing Factor ◽  
Sympathetic Nervous

scholarly journals  Expression of corticotropin releasing factor (CRF) in the enteric nervous system of the jejunum of sheep

2011 ◽  
Vol 56 (No. 11) ◽  
pp. 551-560 ◽  
Author(s):  
A. Czujkowska ◽  
MB Arciszewski
Keyword(s):  
Nervous System ◽  
Smooth Muscle ◽  
Muscle Layer ◽  
Corticotropin Releasing Factor ◽  
Enteric Neurons ◽  
Nerve Fibres ◽  
Myenteric Neurons ◽  
Smooth Muscle Layer ◽  
Circular Smooth Muscle ◽  
A Minor

 Corticotropin releasing factor (CRF), a 41-amino acid neuropeptide widely distributed in the mammalian central nervous system, has been shown to influence several gastrointestinal functions. Recent studies show that CRF released locally from enteric nerves may also underlie alterations in gut function. In this study, immunohistochemisty was applied to demonstrate the presence of CRF in the jejunum of sheep. Using double immunohistochemical staining the co-localization of CRF with vasoactive intestinal peptide (VIP), galanin, tyrosine hydroxylase (TH), neuropeptide Y (NPY) and substance P (SP) was evaluated. The presence of CRF was detected in myenteric neurons (3.6 ± 0.9%) as well as in submucous neurons (10.5 ± 1.2%). In the ovine jejunum different numbers of CRF-expressing nerve fibres were detected in myenteric ganglia, submucous ganglia, circular smooth muscle layer, lamina muscularis mucosae and between mucosal glands. None of the CRF-positive enteric neurons and CRF-positive nerve fibres exhibited the presence of TH. CRF-immunoreactive (IR) myenteric neurons widely co-expressed VIP and/or NPY. A minor population of CRF-IR myenteric neurons additionally co-stored SP. Galanin was not present in CRF-IR myenteric neurons. The presence of VIP was observed in the vast majority of CRF-positive submucous neurons. Moderate numbers of CRF-IR sumbucous neurons co-expressing galanin or NPY were also found. The presence of SP in CRF-positive submucous neurons was noted only incidentally. In the circular smooth muscle layer CRF-IR/VIP-IR, CRF-IR/NPY-IR as well as CRF-IR/SP-IR nerve fibres were present. In the mucosal layer of the ovine jejunum CRF-IR nerve fibres co-stored additionally VIP, galanin, NPY or SP. This present study provides for the first time evidence that CRF present in different subclasses of enteric neurons may influence certain activities of the ovine jejunum. Co-localization studies indicate that VIP, galanin, SP and NPY functionally co-operate with CRF in the jejunum of the sheep.  

Expression of receptors for corticotropin releasing factor in guinea pig enteric nervous system

2003 ◽  
Vol 124 (4) ◽  
pp. A23 ◽  
Author(s):  
Sumei Liu ◽  
Gao Xiang ◽  
Na Gao ◽  
Xiyu Wang ◽  
Hong-Zhen Hu ◽  
...  
Keyword(s):  
Nervous System ◽  
Guinea Pig ◽  
Enteric Nervous System ◽  
Corticotropin Releasing Factor
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