Thirst Mechanism and Its Inhibition

2015 ◽  
pp. 122-129
Author(s):  
Bengt Andersson
Keyword(s):  
Thirst Mechanism

Voluntary dehydration and alliesthesia for water

1984 ◽  
Vol 57 (3) ◽  
pp. 868-873 ◽  
Author(s):  
R. W. Hubbard ◽  
B. L. Sandick ◽  
W. T. Matthew ◽  
R. P. Francesconi ◽  
J. B. Sampson ◽  
...  
Keyword(s):  
Tap Water ◽  
The Other ◽  
Heat Illness ◽  
Complex Relationship ◽  
Fluid Consumption ◽  
Severe Dehydration ◽  
Apparent Paradox ◽  
Weight Losses ◽  
Voluntary Dehydration ◽  
Thirst Mechanism

The purpose of this experiment was to explore the complex relationship between fluid consumption and consumption factors (thirst, voluntary dehydration, water alliesthesia, palatability, work-rest cycle) during a simulated 14.5-km desert walk (treadmill, 1.34 m X s-1, 5% grade, 40 degrees C dry bulb/26 degrees C wet bulb, and wind speed of approximately 1.2 m X s-1). Twenty-nine subjects were tested (30 min X h-1, 6 h) on each of two nonconsecutive days. The subjects were randomly assigned to one of three groups: tap water (n = 8), iodine-treated tap water (n = 11), or iodine-treated flavored tap water (n = 10). The temperature of the water was 40 degrees C during one trial and 15 degrees C on the other. Mean sweat losses (6 h) varied between 1.4 kg (warm iodine-treated; 232 +/- 44 g X h-1) and 3.0 kg (cool iodine-treated flavored; 509 +/- 50 g X h-1). Warm drinks were consumed at a lower rate than cool drinks (negative and positive alliesthesia). This decreased consumption resulted in the highest percent body weight losses (2.8 and 3.2%). Cooling and flavoring effects on consumption were additive and increased the rate of intake by 120%. The apparent paradox between reduced consumption concomitant with severe dehydration and hyperthermia is attributed to negative alliesthesia for warm water rather than an apparent inadequacy of the thirst mechanism. The reluctance to drink warm iodine-treated water resulted in significant hyperthermia, dehydration, hypovolemia, and, in two cases, heat illness.

Ecological adaptation of angiotensin-induced thirst mechanism in tetrapods

1979 ◽  
Vol 38 (1) ◽  
pp. 93-104 ◽  
Author(s):  
Hideshi Kobayashi ◽  
Haruko Uemura ◽  
Masaru Wada ◽  
Yoshio Takei
Keyword(s):  
Ecological Adaptation ◽  
Thirst Mechanism

Abstract #739: Germinoma and Diabetes Insipidus with Absent Thirst Mechanism

2015 ◽  
Vol 21 ◽  
pp. 144-145
Author(s):  
Regina Belokovskaya ◽  
Francisco Perez Mata ◽  
Anna Kausel ◽  
Oksana Davydov ◽  
Robert Bernstein
Keyword(s):  
Diabetes Insipidus ◽  
Thirst Mechanism

Side-effects of lithium at lower therapeutic levels: the significance of thirst

1985 ◽  
Vol 15 (2) ◽  
pp. 355-361 ◽  
Author(s):  
J. R. King ◽  
P. R. Aylard ◽  
R. P. Hullin
Keyword(s):  
Side Effects ◽  
Water Absorption ◽  
Clinical Response ◽  
Psychotropic Drugs ◽  
Urine Flow ◽  
Lithium Level ◽  
Serum Lithium Level ◽  
Length Of Treatment ◽  
Low Levels ◽  
Thirst Mechanism

SynopsisThe prevalence of thirst, subjective polyuria and related side-effects was investigated in 87 patients attending a lithium clinic and in a group of 52 controls. Thirst was surprisingly common, occurring in 67% of patients, in spite of the fact that they had been maintained on relatively low levels of lithium, and was due principally to the lithium rather than to other psychotropic drugs. Urine flow and impaired renal water absorption correlated with the serum lithium level and the length of treatment in the patients, despite the fact that few were clinically polyuric. The pattern of the results confirms previous suggestions that lithium may stimulate the thirst mechanism directly as well as via an increased renal resistance to vasopressin. The possible implications in terms of clinical response are discussed.

scholarly journals Home blood sodium monitoring, sliding-scale fluid prescription and subcutaneous DDAVP for infantile diabetes insipidus with impaired thirst mechanism

2012 ◽  
Vol 2012 (1) ◽  
Author(s):  
Shihab Hameed ◽  
Abel C Mendoza-Cruz ◽  
Kristen A Neville ◽  
Helen J Woodhead ◽  
Jan L Walker ◽  
...  
Keyword(s):  
Diabetes Insipidus ◽  
Sliding Scale ◽  
Thirst Mechanism

scholarly journals The Centenary Celebrations-Insulin and Diabetes.

2021 ◽  
pp. 1-4
Author(s):  
GH Tomkin
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Islet Cells ◽  
The Body ◽  
Obese Patients ◽  
High Concentration ◽  
Huge Amount ◽  
High Blood Sugar ◽  
Hyperosmolar Coma ◽  
Thirst Mechanism

Most people will know the word diabetes. Few people will not know it has something to do with sugar. Diabetes mellitus is the complete name for the condition, mellitus meaning sweet or honey taste found in the urine. Not to be confused with Diabetes insipidus, a condition of the pituitary gland, the kidney or the Psyche where water cannot be retained by the body and very severe thirst and huge polyuria (passing a huge amount of urine occurs). The condition Diabetes mellitus was known in Egyptian times and in recent times has become so much more prevalent. Alas most people will have a relation with the condition and will be aware that complications can occur such as blindness. Even today with all our new medications and all our new knowledge, still diabetes shortens life span by 10 or so years but this figure is rapidly getting less due to earlier diagnosis and better treatment for high blood sugar, cholesterol and high blood pressure. To go back more than 100 years obese patients who developed diabetes could cure the symptoms which include thirst, passing a lot of urine, tiredness and genital itch by weight reduction and exercise. The reason for this improvement is now known in much more detail than it was then. The hormone insulin which is secreted by the islet cells in the pancreas lowers blood sugar. A deficiency of insulin leads to a rising blood sugar and the high blood sugars are the cause of the thirst. The high blood sugar is no longer able to be contained by the kidney and is secreted in the urine. The high concentration of sugar in the urine pulls out sugar by osmosis, drags with it, water, so the higher the glucose in the blood and urine the more water is pulled through the kidneys which are filters. The increased amount of water thus lost, results in frequency of passing water which is now full of glucose. The loss of water is recognised by the thirst mechanism which gets switched on and being very thirsty the patient with diabetes starts to drink and drink to make up for the loss of water in the urine. Sometimes the patient who might have been keen on lemonade or other sweet drinks just drinks more and more not realising that the drinks are heavily laden with sugar. This results in increasing the blood sugar even higher and even more thirst until the whole system collapses. The patient becomes unconscious very dehydrated and will die unless given intravenous fluids and then insulin. One such lady was a patient of mine. The African lady was so complicated that after she recovered we wrote up her case in one of the medical journals to inform others of the problems we faced and the treatments we gave which resulted in her recovery. Hyperosmolar coma is the name of the condition and thankfully rare. I can of course remember other patients who we were not successful in saving but they are too painful to relate.

The threshold osmotic reactivity of the hypothalamo-hypophyseal antidiuretic system and of the thirst mechanism

1971 ◽  
Vol 27 (9) ◽  
pp. 1083-1084 ◽  
Author(s):  
Ewa Szczepańska ◽  
K. Drzewiecki ◽  
S. Kozłowski
Keyword(s):  
Thirst Mechanism
Sign in / Sign up

Export Citation Format

Share Document