Fish Consumption and Prevention of Coronary Heart Disease

2015 ◽  
pp. 51-57
Author(s):  
Daan Kromhout
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Fish Consumption

scholarly journals Longitudinal associations between marine omega-3 supplement users and coronary heart disease in a UK population-based cohort

BMJ Open ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. e017471 ◽  
Author(s):  
Marleen A H Lentjes ◽  
Ruth H Keogh ◽  
Ailsa A Welch ◽  
Angela A Mulligan ◽  
Robert N Luben ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
General Population ◽  
Fish Consumption ◽  
Cox Regression ◽  
Secondary Outcome ◽  
Omega 3 ◽  
Supplement Use ◽  
Pufa Supplement ◽  
Lower Hazard

ObjectivesAssess the association between marine omega-3 polyunsaturated fatty acid (n-3 PUFA) intake from supplements, mainly cod liver oil, and coronary heart disease (CHD) mortality.DesignProspective cohort study, with three exposure measurements over 22 years.SettingNorfolk-based European Prospective Investigation into Cancer (EPIC-Norfolk, UK).Participants22 035 men and women from the general population, 39–79 years at recruitment.ExposureSupplement use was assessed in three questionnaires (1993–1998; 2002–2004; 2004–2011). Participants were grouped into non-supplement users (NSU), n-3 PUFA supplement users (SU+n3) and non–n-3 PUFA supplement users (SU-n3). Cox regression adjusted for time-point specific variables: age, smoking, prevalent illnesses, body mass index, alcohol consumption, physical activity and season and baseline assessments of sex, social class, education and dietary intake (7-day diet diary).Primary and secondary outcome measuresDuring a median of 19-year follow-up, 1562 CHD deaths were registered for 22 035 included participants.ResultsBaseline supplement use was not associated with CHD mortality, but baseline food and supplement intake of n-3 PUFA was inversely associated with CHD mortality after adjustment for fish consumption. Using time-varying covariate analysis, significant associations were observed for SU+n3 (HR: 0.74, 95% CI 0.66 to 0.84), but not for SU-n3 versus NSU. In further analyses, the association for SU+n3 persisted in those who did not take other supplements (HR: 0.83, 95% CI 0.71 to 0.97). Those who became SU+n3 over time or were consistent SU+n3 versus consistent NSU had a lower hazard of CHD mortality; no association with CHD was observed in those who stopped using n-3 PUFA-containing supplements.ConclusionsRecent use of n-3 PUFA supplements was associated with a lower hazard of CHD mortality in this general population with low fish consumption. Residual confounding cannot be excluded, but the findings observed may be explained by postulated biological mechanisms and the results were specific to SU+n3.

scholarly journals Accumulated Evidence on Fish Consumption and Coronary Heart Disease Mortality

Circulation ◽  
2004 ◽  
Vol 109 (22) ◽  
pp. 2705-2711 ◽  
Author(s):  
Ka He ◽  
Yiqing Song ◽  
Martha L. Daviglus ◽  
Kiang Liu ◽  
Linda Van Horn ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Fish Consumption ◽  
Coronary Heart Disease Mortality ◽  
Disease Mortality

scholarly journals Fish Consumption and Coronary Heart Disease: A Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2278
Author(s):  
Bo Zhang ◽  
Ke Xiong ◽  
Jing Cai ◽  
Aiguo Ma
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Dose Response ◽  
Fish Consumption ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Response Analysis ◽  
Summary Estimate ◽  
Incidence And Mortality ◽  
The Impact

Epidemiological studies on the impact of fish consumption on coronary heart disease (CHD) incidence have shown inconsistent results. In addition, in terms of CHD mortality, although previous meta-analyses showed that fish consumption reduces the risk of CHD, six newly incorporated studies show that fish consumption has no impact on CHD. Therefore, the results still need to be verified. The purpose of this study is to quantitatively evaluate the impact of fish consumption on CHD incidence and mortality. Relevant studies were identified from PubMed, Web of Science, and Embase databases up to October 2019. The multivariate-adjusted relative risks (RRs) for the highest versus the lowest fish consumption categories and the 95% confidence intervals were computed with a random-effect model. A restricted cubic spline regression model was used to assess the dose–response relationship between fish consumption and CHD incidence and mortality. Forty prospective cohort studies were incorporated into research. Among them, 22 studies investigated the association between fish consumption and CHD incidence (28,261 cases and 918,783 participants), and the summary estimate showed that higher fish consumption was significantly associated with a lower CHD incidence [RR: 0.91, 95% CI: (0.84, 0.97); I2 = 47.4%]. Twenty-seven studies investigated the association between fish consumption and CHD mortality (10,568 events and 1,139,553 participants), and the summary estimate showed that higher fish intake was significantly associated with a lower CHD mortality [RR: 0.85, 95% CI: (0.77, 0.94); I2 = 51.3%]. The dose–response analysis showed that the CHD incidence and mortality were reduced by 4%, respectively, with a 20 g/day increment in fish consumption. This meta-analysis indicates that fish consumption is associated with a lower CHD incidence and mortality.

Fish consumption and risk of stroke, coronary heart disease, and cardiovascular mortality in a Dutch population with low fish intake

2018 ◽  
Vol 72 (7) ◽  
pp. 942-950 ◽  
Author(s):  
L. M. Hengeveld ◽  
J. Praagman ◽  
J. W. J. Beulens ◽  
I. A. Brouwer ◽  
Y. T. van der Schouw ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Mortality ◽  
Fish Consumption ◽  
Fish Intake ◽  
Dutch Population

scholarly journals Fish consumption and mortality from coronary heart disease.

BMJ ◽  
1986 ◽  
Vol 293 (6544) ◽  
pp. 426-426 ◽  
Author(s):  
S E Norell ◽  
A Ahlbom ◽  
M Feychting ◽  
N L Pedersen
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Fish Consumption
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