DNA Adducts of Cisplatin in Nucleated Peripheral Blood Cells and Tissues of Cancer Patients

2015 ◽  
pp. 104-113 ◽  
Author(s):  
Miriam C. Poirier ◽  
Eddie Reed ◽  
Robert F. Ozols ◽  
Thomas Fasy ◽  
Stuart H. Yuspa
Keyword(s):  
Cancer Patients ◽  
Dna Adducts ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells

scholarly journals Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1324 ◽  
Author(s):  
Balázs ◽  
Kis ◽  
Badie ◽  
Bogdándi ◽  
Candéias ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Local Therapy ◽  
Peripheral Blood Cells ◽  
Immune Parameters ◽  
Induced Changes

Though radiotherapy is a local therapy, it has systemic effects mainly influencing immune and inflammation processes. This has important consequences in the long-term prognosis and therapy individualization. Our objective was to investigate immune and inflammation-related changes in the peripheral blood of head and neck cancer patients treated with radiotherapy. Peripheral blood cells, plasma and blood cell-derived RNA were isolated from 23 patients before and at two time points after radiotherapy and cellular immune parameters, plasma protein changes and gene expression alterations were studied. Increased regulatory T cells and increased CTLA4 and PD-1 expression on CD4 cells indicated an immune suppression induced by the malignant condition, which was accentuated by radiotherapy. Circulating dendritic cells were strongly elevated before treatment and were not affected by radiotherapy. Decreased endoglin levels in the plasma of patients before treatment were further decreased by radiotherapy. Expression of the FXDR, SESN1, GADD45, DDB2 and MDM2 radiation-response genes were altered in the peripheral blood cells of patients after radiotherapy. All changes were long-lasting, detectable one month after radiotherapy. In conclusion we demonstrated radiotherapy-induced changes in systemic immune parameters of head and neck cancer patients and proposed markers suitable for patient stratification worth investigating in larger patient cohorts.

Lipid A OM-174 increases the natural killer activity of peripheral blood cells from breast cancer patients

1999 ◽  
Vol 5 (4) ◽  
pp. 189-195 ◽  
Author(s):  
Danièle Reisser ◽  
Laurent Arnould ◽  
Marc Maynadié ◽  
Catherine Belichard ◽  
Bruno Coudert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Natural Killer ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Lipid A ◽  
Natural Killer Activity ◽  
Peripheral Blood Cells ◽  
Breast Cancer Patients ◽  
Killer Activity
Sign in / Sign up

Export Citation Format

Share Document