Detection of Carcinogen-DNA Adducts in Human Cells and Antibodies to these Adducts in Human Sera

2015 ◽  
pp. 76-85 ◽  
Author(s):  
A. Weston ◽  
G. Trivers ◽  
K. Vahakangas ◽  
M. Newman ◽  
M. Rowe ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Human Cells ◽  
Human Sera

Detection of acrolein and crotonaldehyde DNA adducts in cultured human cells and canine peripheral blood lymphocytes by 32P-postlabeling and nucleotide chromatography

1991 ◽  
Vol 12 (8) ◽  
pp. 1483-1490 ◽  
Author(s):  
Vincent L. Wilson ◽  
Peter G. Foiles ◽  
Fung-Lung Chung ◽  
Andrew C. Povey ◽  
Anthony A. Frank ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Human Cells ◽  
Blood Lymphocytes ◽  
Cultured Human Cells

scholarly journals Impact of tobacco-specific nitrosamine–derived DNA adducts on the efficiency and fidelity of DNA replication in human cells

2018 ◽  
Vol 293 (28) ◽  
pp. 11100-11108 ◽  
Author(s):  
Hua Du ◽  
Jiapeng Leng ◽  
Pengcheng Wang ◽  
Lin Li ◽  
Yinsheng Wang
Keyword(s):  
Dna Replication ◽  
Dna Adducts ◽  
Human Cells

scholarly journals Lack of Mutagenicity of Acrolein-Induced DNA Adducts in Mouse and Human Cells

2007 ◽  
Vol 67 (24) ◽  
pp. 11640-11647 ◽  
Author(s):  
S.-i. Kim ◽  
G. P. Pfeifer ◽  
A. Besaratinia
Keyword(s):  
Dna Adducts ◽  
Human Cells

Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells

2006 ◽  
Vol 608 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Scott Stein ◽  
Yanbin Lao ◽  
In-Young Yang ◽  
Stephen S. Hecht ◽  
Masaaki Moriya
Keyword(s):  
Dna Adducts ◽  
Human Cells

Excision of hydrocarbon-DNA adducts and consequent cell survival in normal and repair defective human cells

1978 ◽  
Vol 22 (2-3) ◽  
pp. 139-151 ◽  
Author(s):  
Billie A. McCaw ◽  
Anthony Dipple ◽  
Susan Young ◽  
John J. Roberts
Keyword(s):  
Cell Survival ◽  
Dna Adducts ◽  
Human Cells

Detection of Carcinogen–Macromolecular Adducts in Humans

1989 ◽  
Vol 8 (5) ◽  
pp. 913-932 ◽  
Author(s):  
A. Weston ◽  
D. K. Manchester ◽  
A. Povey ◽  
C. C. Harris
Keyword(s):  
Dna Adducts ◽  
Alkylating Agents ◽  
Dna Lesions ◽  
Target Cells ◽  
High Exposure ◽  
Increased Risk ◽  
Polycyclic Aromatic ◽  
Human Sera ◽  
Carcinogen Exposure ◽  
Risk Of Cancer

A major concern of molecular epidemiology is the identification of individuals at increased risk of cancer by obtaining evidence of high exposure to carcinogens that may lead to pathobiological lesions in target cells. DNA is considered to be a target for modification by mutagens and carcinogens; therefore, damage to DNA can be used as an internal, molecular dosimeter of carcinogen exposure. The reactive species of these carcinogens may bind either directly to DNA to form adducts or indirectly to cause secondary DNA lesions through free radicals and aldehydes. Highly sensitive and specific methods have been developed to measure DNA lesions and DNA repair products that are found in biological specimens from humans exposed to carcinogens in the environment. For example, DNA adducts have been measured in cells and tissues from people exposed environmentally to carcinogenic polycyclic aromatic hydrocarbons or alkylating agents. Antibodies recognizing carcinogen-DNA adducts have also been detected in human sera. Carcinogen-protein adducts are also being used as molecular dosimeters of carcinogen exposure. The advantages and limitations of the various methods used to measure carcinogen-macromolecular adducts are discussed here. The use of two or more complementary assays to obtain confirmatory results is recommended.

DNA repair in human cells: quantitative assessment of bulky anti-BPDE-DNA adducts by non-competitive immunoassays

1995 ◽  
Vol 16 (9) ◽  
pp. 2029-2036 ◽  
Author(s):  
Sundaresan Venkatachalam ◽  
Mikhail Denissenko ◽  
Altaf A. Wani
Keyword(s):  
Dna Repair ◽  
Dna Adducts ◽  
Quantitative Assessment ◽  
Human Cells
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