Structural and Functional Alterations in the Diabetic Kidney

2015 ◽  
pp. 67-81 ◽  
Author(s):  
Carl Erik Mogensen ◽  
Ruth �sterby
Keyword(s):  
Diabetic Kidney ◽  
In The Diabetic Kidney

scholarly journals The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
M. C. Thomas ◽  
K. A. Jandeleit-Dahm ◽  
C. Tikellis
Keyword(s):  
Cardiovascular Effects ◽  
Lipid Lowering ◽  
Peroxisome Proliferator ◽  
Oral Hypoglycaemic Agents ◽  
Diabetic Kidney ◽  
Critical Pathways ◽  
Patients With Diabetes ◽  
Ppar Agonists ◽  
Peroxisome Proliferator Activated Receptors ◽  
In The Diabetic Kidney

Pharmaceutical agonists of peroxisome proliferator-activated receptors (PPARs) are widely used in the management of type 2 diabetes, chiefly as lipid-lowering agents and oral hypoglycaemic agents. Although most of the focus has been placed on their cardiovascular effects, both positive and negative, these agents also have significant renoprotective actions in the diabetic kidney. Over and above action on metabolic control and effects on blood pressure, PPAR agonists also appear to have independent effects on a number of critical pathways that are implicated in the development and progression of diabetic kidney disease, including oxidative stress, inflammation, hypertrophy, and podocyte function. This review will examine these direct and indirect actions of PPAR agonists in the diabetic kidney and explore recent findings of clinical trials of PPAR agonists in patients with diabetes.

scholarly journals Glucose and glycogen in the diabetic kidney: Heroes or villains?

EBioMedicine ◽  
2019 ◽  
Vol 47 ◽  
pp. 590-597 ◽  
Author(s):  
Mitchell A. Sullivan ◽  
Josephine M. Forbes
Keyword(s):  
Diabetic Kidney ◽  
In The Diabetic Kidney

scholarly journals Interacting hypoxia and endothelin in the diabetic kidney: therapeutic options

2018 ◽  
Vol 314 (5) ◽  
pp. F699-F701
Author(s):  
Samuel N. Heyman ◽  
Mogher Khamaisi ◽  
Zaid Abassi
Keyword(s):  
Therapeutic Options ◽  
Diabetic Kidney ◽  
In The Diabetic Kidney

scholarly journals Mitochondrial Damage and Protein Modification in the Diabetic Kidney Mouse Model

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Ganesh Krishna Kartha ◽  
Karni S. Moshal ◽  
Neetu Tyagi ◽  
Walter E. Rodriguez ◽  
Mesia B. Steed ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protein Modification ◽  
Mitochondrial Damage ◽  
Diabetic Kidney ◽  
In The Diabetic Kidney
Sign in / Sign up

Export Citation Format

Share Document