Radiocontrast Media Nephrotoxicity1

Faculty Opinions recommendation of Radiocontrast media hypersensitivity: skin testing differentiates allergy from nonallergic reactions and identifies a safe alternative as proven by intravenous provocation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735543706.793566285 ◽

2019 ◽

Author(s):

Timothy Craig ◽

Aparna Daley

Keyword(s):

Skin Testing ◽

Safe Alternative ◽

Radiocontrast Media ◽

Hypersensitivity Skin

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Impact of an electronic consultant system on hypersensitivity reactions to iodinated radiocontrast media: an observational study

Postgraduate Medical Journal ◽

10.1136/postgradmedj-2013-132538 ◽

2015 ◽

Vol 91 (1074) ◽

pp. 193-199 ◽

Cited By ~ 5

Author(s):

Min-Suk Yang ◽

Sang-Il Choi ◽

Woo-Jung Song ◽

Sae-Hoon Kim ◽

Hye-Ryun Kang ◽

...

Keyword(s):

Observational Study ◽

Hypersensitivity Reactions ◽

Radiocontrast Media

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Prophylaxis Against Repeated Radiocontrast Media Reactions in 857 Cases. Adverse Experience With Cimetidine and Safety of β-Adrenergic Antagonists

The Journal of Urology ◽

10.1016/s0022-5347(17)44798-7 ◽

1986 ◽

Vol 136 (1 Part 1) ◽

pp. 193-193

Author(s):

P.A. Greenberger ◽

R. Patterson ◽

C.M. Tapio

Keyword(s):

Adverse Experience ◽

Radiocontrast Media ◽

Adrenergic Antagonists

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Electronic Consultation Support System for Radiocontrast Media Hypersensitivity Changes Clinicians' Behavior

Allergy Asthma and Immunology Research ◽

10.4168/aair.2018.10.2.165 ◽

2018 ◽

Vol 10 (2) ◽

pp. 165 ◽

Cited By ~ 1

Author(s):

Min-Suk Yang ◽

Sang-Il Choi ◽

Woo-Jung Song ◽

Sae-Hoon Kim ◽

Sang-Heon Cho ◽

...

Keyword(s):

Support System ◽

Radiocontrast Media ◽

Electronic Consultation

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Anaphylaxis

Oxford Textbook of Medicine ◽

10.1093/med/9780199204854.003.1702_update_001 ◽

2010 ◽

pp. 3106-3114 ◽

Cited By ~ 1

Author(s):

Anthony F.T. Brown

Keyword(s):

Mast Cell ◽

Smooth Muscle Contraction ◽

Lipid Mediators ◽

Feedback Mechanisms ◽

Radiocontrast Media ◽

Cytokines And Chemokines ◽

Immune Mediated ◽

Common Causes ◽

Inflammatory Drugs ◽

Cytokine Cascade

The term anaphylaxis describes both IgE immune-mediated reactions and nonallergic, nonimmunologically triggered events. Comorbidities such as asthma or infection, exercise, alcohol, or stress and concurrent medications such as β‎-blockers and aspirin increase the risk known as ‘summation anaphylaxis’. Aetiology and pathogenesis—activated mast cells and basophils release preformed, granule-associated mediators and newly formed lipid mediators, and generate cytokines and chemokines. These cause vasodilatation, increased capillary permeability, and smooth muscle contraction, as well as attract new cells to the area. Positive feedback mechanisms amplify the reaction in a ‘mast cell—leucocyte cytokine cascade’, although conversely reactions can be self-limiting. Parenteral penicillins, hymenopteran stings, and food are the most common causes of IgE immune-mediated fatalities, with radiocontrast media, aspirin, and other nonsteroidal anti-inflammatory drugs most commonly responsible for nonallergic fatalities....

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Anaphylaxis

Oxford Textbook of Medicine ◽

10.1093/med/9780198746690.003.0386 ◽

2020 ◽

pp. 3849-3859

Author(s):

Anthony F.T. Brown

Keyword(s):

Mast Cell ◽

Immunoglobulin E ◽

Smooth Muscle Contraction ◽

Lipid Mediators ◽

Radiocontrast Media ◽

Cytokines And Chemokines ◽

Immune Mediated ◽

Common Causes ◽

Inflammatory Drugs ◽

Cytokine Cascade

The term anaphylaxis describes both immunoglobulin E (IgE) immune-mediated reactions, plus non-IgE immune-mediated, and non-allergic, non-immunologically triggered events. Comorbidities such as asthma or infection, exercise, alcohol, or stress and concurrent medications such as β‎-blockers and aspirin increase the risk, a concept known as ‘summation anaphylaxis’. Activated mast cells and basophils release preformed, granule-associated mediators and newly formed lipid mediators, and generate cytokines and chemokines. These cause vasodilatation, increased capillary permeability, and smooth muscle contraction, as well as attracting new cells to the area. Positive feedback enhancing mechanisms amplify the reaction in a ‘mast cell—leucocyte cytokine cascade’, although conversely reactions can be self-limiting. Parenteral penicillins, hymenopteran stings, and food are the most common causes of IgE immune-mediated fatalities, with radiocontrast media, aspirin, and other non-steroidal anti-inflammatory drugs most commonly responsible for non-IgE and non-allergic fatalities.

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