Alveolar Plateau Caused by P-V Heterogeneity and Cardiogenic Oscillations Generated by Differential Effect of the Heart - A Model

Author(s):  
Ran Arieli ◽  
Fred Wiener
1986 ◽  
Vol 60 (6) ◽  
pp. 2101-2108 ◽  
Author(s):  
R. Arieli ◽  
F. Wiener ◽  
E. Levitan

The effect of heterogeneity of pressure-volume (PV) behavior of lung units and the effect of the pulsations of the heart on expired N2 following a single breath of O2 were studied mathematically in a model of the lung. The lung was pictured as consisting of three compartments, one of high compliance (HC) and another of low compliance (LC), both affected by cardiac pulsations, and a third, nonoscillatory compartment (NC). Three sigmoid PV curves were assigned to the three compartments, for both acini and airway (generation 10–23), so that total compliance summed up to 200 ml/cmH2O. Bifurcation of NC was at generation 5/6 and that of HC and LC at any chosen generation. A steepness constant, K, was defined to characterize the sharply descending portion of the sigmoid PV curve. For a ratio of the steepness constant for the oscillatory compartments, KHC/KLC = 1, a sloping alveolar plateau was produced. The plateau was concave for KHC/KLC greater than 1 and slightly convex for KHC/KLC less than 1. Cardiogenic oscillations (CO) of the expired N2 were produced by alternate flows from either NC or HC and LC. CO diminished in fast expiration, and a phase shift between the heart pulsation and the CO was seen; both agree with experimental findings.


Author(s):  
Sylvie Willems ◽  
Jonathan Dedonder ◽  
Martial Van der Linden

In line with Whittlesea and Price (2001) , we investigated whether the memory effect measured with an implicit memory paradigm (mere exposure effect) and an explicit recognition task depended on perceptual processing strategies, regardless of whether the task required intentional retrieval. We found that manipulation intended to prompt functional implicit-explicit dissociation no longer had a differential effect when we induced similar perceptual strategies in both tasks. Indeed, the results showed that prompting a nonanalytic strategy ensured performance above chance on both tasks. Conversely, inducing an analytic strategy drastically decreased both explicit and implicit performance. Furthermore, we noted that the nonanalytic strategy involved less extensive gaze scanning than the analytic strategy and that memory effects under this processing strategy were largely independent of gaze movement.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1707-P
Author(s):  
XI CHEN ◽  
XIANLIN HAN ◽  
JONATHAN TREJO ◽  
EMINA CASE ◽  
RALPH A. DEFRONZO ◽  
...  
Keyword(s):  

Diabetes ◽  
1992 ◽  
Vol 41 (3) ◽  
pp. 261-266 ◽  
Author(s):  
T. A. Mori ◽  
R. Vandongen ◽  
A. J. Douglas ◽  
R. K. McCulloch ◽  
V. Burke

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