Role of Transmembrane Signaling Systems and Protein Kinase C in Modulating Cell Proliferation and Neoplastic Transformation

1986 ◽  
pp. 17-25 ◽  
Author(s):  
W. B. Anderson ◽  
T. P. Thomas ◽  
H. Talwar ◽  
R. Gopalakrishna
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Neoplastic Transformation ◽  
Transmembrane Signaling ◽  
Signaling Systems ◽  
Kinase C

Role of protein kinase C in transmembrane signaling

1985 ◽  
Vol 29 (2) ◽  
pp. 143-155 ◽  
Author(s):  
Yoshimi Takai ◽  
Kozo Kaibuchi ◽  
Terutaka Tsuda ◽  
Masahiko Hoshijima
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Transmembrane Signaling ◽  
Kinase C

Role of protein kinase C in induction of gene expression and inhibition of cell proliferation by interferon alpha

1992 ◽  
Vol 209 (3) ◽  
pp. 813-822 ◽  
Author(s):  
Robert I. JAMES ◽  
Juan MENAYA ◽  
Kati HUDSON ◽  
Vinod DEVALIA ◽  
Jonathan RYVES ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Interferon Alpha ◽  
Kinase C

scholarly journals Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C.

1991 ◽  
Vol 266 (10) ◽  
pp. 6188-6194
Author(s):  
D Boscoboinik ◽  
A Szewczyk ◽  
C Hensey ◽  
A Azzi
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Alpha Tocopherol ◽  
Kinase C

Role of protein kinase C and cAMP in fluoxetine effects on human T-cell proliferation

1999 ◽  
Vol 372 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Valeria Ayelli Edgar ◽  
Leonor Sterin-Borda ◽  
Graciela A Cremaschi ◽  
Ana M Genaro
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
T Cell Proliferation ◽  
Kinase C ◽  
Human T Cell

scholarly journals Potentiation response of cultured human uterine leiomyoma cells to various growth factors by endothelin-1: role of protein kinase C

2001 ◽  
pp. 543-548 ◽  
Author(s):  
I Eude ◽  
E Dallot ◽  
MC Vacher-Lavenu ◽  
C Chapron ◽  
F Ferre ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
Growth Factors ◽  
Growth Factor ◽  
Protein Kinase ◽  
Cell Growth ◽  
Endothelin 1 ◽  
Kinase C ◽  
Pkc Isoforms

OBJECTIVE: Factors responsible for the abnormal proliferation of myometrial cells that accompanies leiomyoma formation are unknown, although steroid hormones and peptide growth factors have been implicated. We hypothesized that endothelin-1 (ET-1) is a physiological regulator of tumor growth. DESIGN: In this study, we investigated the role of ET-1 on growth of human leiomyoma cells and its synergistic effect with growth factors, as well as the signaling pathway involved in this interaction. METHODS: Leiomyoma cell proliferation was assayed by [H]thymidine incorporation and cell number. Protein kinase C (PKC) isoforms were analyzed by Western blot using specific antibodies. RESULTS: ET-1 on its own was unable to stimulate DNA synthesis but potentiated the leiomyoma cell growth effects of basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), IGF-I and IGF-II. The failure of a protein tyrosine kinase (PTK) inhibitor, tyrphostin 51, to affect the potentiating effect of ET-1, supports the hypothesis of non-involvement of PTK in this process. The inhibition of PKC by calphostin C or its down-regulation by phorbol 12,13-dibutyrate (PDB) eliminated the potentiating effect of ET-1, but did not block cell proliferation induced by the growth factors alone. Five PKC isoforms (alpha, beta1, epsilon, delta and zeta) were detected in leiomyoma cells, but only phorbol ester-sensitive PKC isoforms (PKCalpha, epsilon and delta) contribute to the potentiating effect of leiomyoma cell growth by ET-1. CONCLUSIONS: We have demonstrated that ET-1 potentiates leiomyoma cell proliferation to growth factors through a PKC-dependent pathway. These findings suggest a possible involvement of ET-1 in the pathogenesis of leiomyomas.

Lipopolysaccharide-induced murine B cell proliferation: A role of protein kinase C

1988 ◽  
Vol 117 (2) ◽  
pp. 425-429 ◽  
Author(s):  
Sudhir Gupta ◽  
Sastry Gollapudi ◽  
Bharathi Vayuvegula
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
B Cell ◽  
Kinase C
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