The Influence of Maternal Adrenal Function during Gestation on Hormonal and Long-Term Behavioral Parameters in the Offspring of Rats1

2015 ◽  
pp. 112-116 ◽  
Author(s):  
Franziska G�tz ◽  
Fritz Stahl ◽  
Tomi Ohkawa ◽  
Neida Mendez-Gomez ◽  
G�nter D�rner
Keyword(s):  
Adrenal Function ◽  
Behavioral Parameters

PITUITARY-ADRENAL FUNCTION IN RATS FOLLOWING LONG-TERM CORTISOL TREATMENT

1969 ◽  
Vol 61 (1_Suppl) ◽  
pp. S113
Author(s):  
J. R. Hodges ◽  
Janet Sadow
Keyword(s):  
Adrenal Function

scholarly journals Adrenal function during long‐term ACTH therapy for patients with developmental and epileptic encephalopathy

2021 ◽  
Author(s):  
Yuki Ueda ◽  
Shuta Fujishige ◽  
Takeru Goto ◽  
Shuhei Kimura ◽  
Noriko Namatame ◽  
...  
Keyword(s):  
Epileptic Encephalopathy ◽  
Adrenal Function ◽  
Acth Therapy

Long-term triphenyltin exposure disrupts adrenal function in adult male rats

Chemosphere ◽  
2020 ◽  
Vol 243 ◽  
pp. 125149 ◽  
Author(s):  
Keyang Wu ◽  
Yang Li ◽  
Jianpeng Liu ◽  
Jiaying Mo ◽  
Xiaoheng Li ◽  
...  
Keyword(s):  
Adult Male ◽  
Adrenal Function ◽  
Male Rats

Effects of long-term hypoxemia on pituitary-adrenal function in fetal sheep

1996 ◽  
Vol 271 (4) ◽  
pp. E678-E685 ◽  
Author(s):  
J. Murotsuki ◽  
R. Gagnon ◽  
S. G. Matthews ◽  
J. R. Challis
Keyword(s):  
Adrenal Function ◽  
Arterial Oxygen ◽  
Pars Intermedia ◽  
Mrna Levels ◽  
Pars Distalis ◽  
Fetal Sheep ◽  
Fetal Plasma ◽  
Pomc Mrna ◽  
Pregnant Sheep

To test the hypothesis that long-term hypoxemia causes premature activation of the fetal pituitary-adrenal function, we embolized the fetal side of the placenta in pregnant sheep and examined the changes in concentrations of immunoreactive adrenocorticotropic hormone (irACTH), cortisol, and prostaglandin E2 (PGE2) in fetal plasma, and levels and localization of proopiomelanocortin (POMC) mRNA in the pars distalis and the pars intermedia of the fetal pituitary. Twelve fetal sheep were studied (6 embolized and 6 control) for 21 days between 0.74 and 0.88 of gestation. Daily injections of nonradiolabeled microspheres were given into the fetal abdominal aorta to decrease fetal arterial oxygen content by 40-50% of the preembolization values. In the embolized group, concentrations of irACTH, PGE2, and cortisol in fetal plasma increased gradually and were significantly (P < 0.05) elevated above those of controls after day 10, day 16, and day 20, respectively. POMC mRNA levels in the pars distalis of the fetal pituitary were not different from those of controls but were significantly reduced in the pars intermedia (P < 0.05). We conclude that levels of POMC mRNA in the pars distalis are unchanged during long-term hypoxemia possibly because of negative feedback effects of elevated cortisol on the pituitary gland. During long-term fetal hypoxemia, there is a differential regulation of POMC mRNA expression in the pars distalis and pars intermedia.

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