Effects of Plasmapheresis on Renal Lesions in Lupus Nephritis

2015 ◽  
pp. 384-389
Author(s):  
V. Bonomini ◽  
A. Vangelista ◽  
G. Frasc� ◽  
A. Bonifati ◽  
A. Buscaroli ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Renal Lesions

scholarly journals P189 Antiphospholipid antibodies and vascular renal lesions as prognostic factors in lupus nephritis

2020 ◽  
Author(s):  
Annamaria Paglionico ◽  
Valentina Varriano ◽  
Luca Petricca ◽  
Clara Di Marioa ◽  
Maria Rita Gigante ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lupus Nephritis ◽  
Antiphospholipid Antibodies ◽  
Renal Lesions

scholarly journals Vasculature-Associated Lymphoid Tissue: A Unique Tertiary Lymphoid Tissue Correlates With Renal Lesions in Lupus Nephritis Mouse Model

2020 ◽  
Vol 11 ◽  
Author(s):  
Md. Abdul Masum ◽  
Osamu Ichii ◽  
Yaser Hosny Ali Elewa ◽  
Yuki Otani ◽  
Takashi Namba ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Immune Cells ◽  
Lymphoid Tissue ◽  
Young Patients ◽  
Chemokine Production ◽  
Tertiary Lymphoid Tissue ◽  
Renal Lesions ◽  
Tissue Organization ◽  
Lymphocyte Activity ◽  
Center Activity

Lupus nephritis (LN) is a common complication in young patients and the most predominant cause of glomerulonephritis. Infiltrating immune cells and presence of immunocomplexes in the kidney are hallmarks of LN, which is closely associated with renal lesions (RLs). However, their regulatory mechanism in the kidney remains unclear, which is valuable for prevention of RL development. Here, we show the development of vasculature-associated lymphoid tissue (VALT) in LN, which is related to renal inflammatory cytokines, indicating that VALT is a unique tertiary lymphoid tissue. Transcriptomic analysis revealed different chemokines and costimulatory molecules for VALT induction and organization. Vascular and perivascular structures showed lymphoid tissue organization through lymphorganogenic chemokine production. Transcriptional profile and intracellular interaction also demonstrated antigen presentation, lymphocyte activity, clonal expansion, follicular, and germinal center activity in VALT. Importantly, VALT size was correlated with infiltrating immune cells in kidney and RLs, indicating its direct correlation with the development of RLs. In addition, dexamethasone administration reduced VALT size. Therefore, inhibition of VALT formation would be a novel therapeutic strategy against LN.

scholarly journals SAT0224 ANTIPHOSPHOLIPID ANTIBODIES AND VASCULAR RENAL LESIONS AS PROGNOSTIC FACTORS IN LUPUS NEPHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1055.3-1055
Author(s):  
A. Paglionico ◽  
V. Varriano ◽  
L. Petricca ◽  
G. Vischini ◽  
C. DI Mario ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Clinical Outcome ◽  
Antiphospholipid Antibodies ◽  
Vascular Lesions ◽  
Renal Outcome ◽  
Rank Test ◽  
Late Time ◽  
Renal Lesions ◽  
Log Rank Test

Background:Several studies have showed that antiphospholipid antibodies (aPL) positivity represents a predictor of worse renal outcome in patients with Lupus Nephritis (LN). In addition, an association between aPL positivity and the histological data of vascular lesions on the renal biopsies has been reported.Objectives:To determine the prognostic role of aPL and vascular renal lesions in the assessment of clinical outcome during the follow up period, in terms of time to achieve remission, number of renal flares and development of chronic renal damage in patients affected by LN.Methods:Among 120 patients affected by LN from our Rheumatology Unit, 91 patients (age 43.8 ± 12 years, 74 (81.3%) female, disease duration 7.1 ± 7.9 years) have been evaluated and the follow-up data have been collected at the baseline and at 6, 12, 24 months and at the last follow-up visit. Histopathological data of 41 patients were evaluated according to the 2016 revision of ISN/RPS classification.Results:Among the 91 LN patients, 31 (34.1%) were aPL positive (aPL+), 10 (32.2%) of them were affected by Antiphospholipid Antibodies Syndrome (APS), 53.3% showed a single aPL positivity, 23.1% double aPL positivity and 15.4% triple aPL positivity. At the last follow up visit a significant higher number of aPL+ patients showed a persistent complement consumption than aPL negative (aPL-) patients (p=0.001). Evaluating clinical outcome, we observed that aPL- patients showed a remission achievement time slightly earlier than aPL+ patients (13.6 ± 1.0 months vs 16.5 ± 1.5 months; log-rank test: p=0.06, Breslow test: p=0.08) and as expected, patients with a persistent complement consumption achieve remission later (18.2 ± 1.5 months vs 13.0 ± 1 months; log-rank test: p=0.002, Breslow test: p=0.003). Furthermore at the last follow up, a significant higher percentage of aPL+ patients developed persistent proteinuria (p=0.02) and chronic renal failure (p=0.04). Considering histologic features (activity and chronicity index, glomerulonephritis class, presence of mesangiolysis, glomerular wrinkling, glomerular thrombi, interstitial inflammatory infiltrates, interstitial fibrosis and tubular atrophy,tubulitis and vascular lesions) we didn’t observe significant differences between aPL+ and aPL- patients but we found two typical vascular lesions (mesangiolysis and vascular thrombi) only in aPL + patients.Conclusion:aPL positivity is a predictor of worse renal outcome but in our cohort of LN patients we didn’t find an association between aPL positivity and vascular renal lesions at renal biopsy. The worse renal outcome and the late time to achieve remission in aPL+ group can be related to a cumulative vascular damage over time as observed in other organ and systems.Disclosure of Interests:None declared

1913: The Radiographic Evolution of Radio Frequency Ablated Renal Lesions

2004 ◽  
Vol 171 (4S) ◽  
pp. 505-505
Author(s):  
Edward D. Matsumoto ◽  
Lori Watumall ◽  
D. Brooke Johnson ◽  
Kenneth Ogan ◽  
Grant D. Taylor ◽  
...  
Keyword(s):  
Radio Frequency ◽  
Renal Lesions

Liquoid Induced Stasis and the Generalized Shwartzman Reaction

1979 ◽  
Vol 41 (04) ◽  
pp. 804-810 ◽  
Author(s):  
Knut Nordstoga
Keyword(s):  
Red Cells ◽  
Renal Lesions ◽  
Intravenous Injections ◽  
Shwartzman Reaction ◽  
Glomerular Capillaries

SummaryThe composition of the occlusive material within dilated glomerular capillaries, following intravenous injections of Liquoid in blue foxes, was studied electron microscopically; it was found that it mainly consisted of a debris in which disintegrated red cells constituted the major component. Damaged platelets and necrotic endothelial remnants were other components. These observations were interpreted as a result of glomerular stasis, and it was concluded that stasis in glomerular capillaries is a basic event in the development of the renal lesions accompanying the generalized Shwartzman reaction.

A Re-Appraisal of the Role of Blood Coagulation and Platelets in the Generalized Shwartzman Phenomenon

1966 ◽  
Vol 15 (03/04) ◽  
pp. 519-538 ◽  
Author(s):  
J Levin ◽  
E Beck
Keyword(s):  
Blood Coagulation ◽  
The State ◽  
Coagulation System ◽  
Renal Lesions ◽  
Intravascular Coagulation ◽  
Renal Glomeruli ◽  
Coagulation Mechanism ◽  
Shwartzman Phenomenon ◽  
Do So

SummaryThe role of intravascular coagulation in the production of the generalized Shwartzman phenomenon has been evaluated. The administration of endotoxin to animals prepared with Thorotrast results in activation of the coagulation mechanism with the resultant deposition of fibrinoid material in the renal glomeruli. Anticoagulation prevents alterations in the state of the coagulation system and inhibits development of the renal lesions. Platelets are not primarily involved. Platelet antiserum produces similar lesions in animals prepared with Thorotrast, but appears to do so in a manner which does not significantly involve intravascular coagulation.The production of adrenal cortical hemorrhage, comparable to that seen in the Waterhouse-Friderichsen syndrome, following the administration of endotoxin to animals that had previously received ACTH does not require intravascular coagulation and may not be a manifestation of the generalized Shwartzman phenomenon.

EVALUATION OF FOCAL RENAL LESIONS WITH CONTRAST ENHANCED GREY-SCALE HARMONIC ULTRASOUND

2005 ◽  
Vol 26 (S 1) ◽  
Author(s):  
F Frauscher ◽  
L Pallwein ◽  
J Gradl ◽  
M Schurich ◽  
A Pelzer ◽  
...  
Keyword(s):  
Renal Lesions ◽  
Grey Scale ◽  
Contrast Enhanced
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