A New Experimental Approach in the Study of Serum Bactericidal Activity in Liver Cirrhosis

2015 ◽  
pp. 182-192
Author(s):  
Maddalena Miccio ◽  
N. Miani ◽  
Barbara Skerlavaj ◽  
G. Zabucchi ◽  
C. Tiribelli
Keyword(s):  
Liver Cirrhosis ◽  
Bactericidal Activity ◽  
Experimental Approach ◽  
Serum Bactericidal Activity

scholarly journals BIOCINE® MENINGOCOCCAL C (MenC) CONJUGATE VACCINE ELICITS HIGH TITERS OF SERUM BACTERICIDAL ACTIVITY IN TODDLERS. ▴ 1053

1996 ◽  
Vol 39 ◽  
pp. 178-178 ◽  
Author(s):  
Noni N.E MacDonald ◽  
Scott Halperin ◽  
Barbara Law ◽  
Bruce D Forrest ◽  
Ahmad Mokatrin ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Bactericidal Activity ◽  
Serum Bactericidal Activity

scholarly journals Antiidiotypic DNA vaccination induces serum bactericidal activity and protection against group B meningococci

2006 ◽  
Vol 203 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Concetta Beninati ◽  
Angelina Midiri ◽  
Giuseppe Mancuso ◽  
Carmelo Biondo ◽  
Milena Arigò ◽  
...  
Keyword(s):  
Bactericidal Activity ◽  
Capsular Polysaccharide ◽  
Signal Sequence ◽  
Developed Countries ◽  
Single Chain ◽  
Serum Bactericidal Activity ◽  
Scfv Gene ◽  
Genes Encoding ◽  
Encapsulated Bacteria ◽  
Group B

No vaccine is available for preventing infections by serogroup B Neisseria meningitidis (MenB), which accounts for a major portion of meningococcal cases in developed countries, because of the poor immunogenicity of the capsular polysaccharide (CP) even after protein conjugation. We have previously induced anticapsular antibodies by immunization with a single chain variable fragment (scFv), which mimics a protective CP epitope. This surrogate antigen, however, was ineffective at inducing serum bactericidal activity, an accepted marker of protection in humans. Serum bactericidal activity was consistently achieved by immunizing mice with the scFv-encoding gene. Immunization with vectors without a secretory signal sequence before the scFv resulted in markedly higher bactericidal activity relative to those with such a sequence. The induced antibodies were capsule specific, as shown by complete inhibition of bactericidal activity by purified MenB CP and by resistance to killing of MenA or MenC. Moreover, these antibodies were predominantly of the IgG2a isotype, reflecting a T helper type 1 response. Administration of sera from scFv gene–vaccinated animals protected infant rats against MenB bacteremia. These data illustrate the potential of vaccination with genes encoding capsular mimics in providing protection against MenB and other encapsulated bacteria.

EFFECT OF RENAL PHYSICO-CHEMICAL MILIEU ON SERUM BACTERICIDAL ACTIVITY

1967 ◽  
Vol 253 (2) ◽  
pp. 225-229 ◽  
Author(s):  
EARL G. HUBERT ◽  
JOHN Z. MONTGOMERIE ◽  
GEOUGE M. KALMANSON ◽  
LUCIEN N. GUZE
Keyword(s):  
Bactericidal Activity ◽  
Serum Bactericidal Activity ◽  
Physico Chemical

Comparative serum bactericidal activity against test anaerobes in volunteers receiving imipenem, clindamycin, latamoxef and metronidazole

1987 ◽  
Vol 19 (2) ◽  
pp. 205-210 ◽  
Author(s):  
P. Van der Auwera ◽  
Y. Van Laethem ◽  
N. Defresne ◽  
M. Husson ◽  
J. Klastersky
Keyword(s):  
Bactericidal Activity ◽  
Serum Bactericidal Activity
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