Long-Term Effects of Low-Dose Thiazide and Amiloride Administration in Recurrent Renal Stone Formers

2015 ◽  
pp. 108-117 ◽  
Author(s):  
Giuseppe Maschio ◽  
Angela D�Angelo ◽  
Antonia Fabris ◽  
Nicola Tessitore ◽  
Leonardo Sartori ◽  
...  
Keyword(s):  
Low Dose ◽  
Renal Stone ◽  
Long Term Effects ◽  
Stone Formers

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

scholarly journals First Insights into the Effect of Low-Dose X-Ray Irradiation in Adipose-Derived Stem Cells

2019 ◽  
Vol 20 (23) ◽  
pp. 6075 ◽  
Author(s):  
Annemarie Schröder ◽  
Stephan Kriesen ◽  
Guido Hildebrandt ◽  
Katrin Manda
Keyword(s):  
Stem Cells ◽  
Low Dose ◽  
Dose Range ◽  
Adipose Derived Stem Cells ◽  
Long Term Effects ◽  
Low Dose Radiation ◽  
Term Survival ◽  
Cell Therapies ◽  
Dose Radiation

(1) Background: Emerging interest of physicians to use adipose-derived stem cells (ADSCs) for regenerative therapies and the fact that low-dose irradiation (LD-IR ≤ 0.1 Gy) has been reported to enhance the proliferation of several human normal and bone-marrow stem cells, but not that of tumor cells, lead to the idea of improving stem cell therapies via low-dose radiation. Therefore, the aim of this study was to investigate unwanted side effects, as well as proliferation-stimulating mechanisms of LD-IR on ADSCs. (2) Methods: To avoid donor specific effects, ADSCs isolated from mamma reductions of 10 donors were pooled and used for the radiobiological analysis. The clonogenic survival assay was used to classify the long-term effects of low-dose radiation in ADSCs. Afterwards, cytotoxicity and genotoxicity, as well as the effect of irradiation on proliferation of ADSCs were investigated. (3) Results: LD (≤ 0.1 Gy) of ionizing radiation promoted the proliferation and survival of ADSCs. Within this dose range neither geno- nor cytotoxic effects were detectable. In contrast, greater doses within the dose range of >0.1–2.0 Gy induced residual double-strand breaks and reduced the long-term survival, as well as the proliferation rate of ADSCs. (4) Conclusions: Our data suggest that ADSCs are resistant to LD-IR. Furthermore, LD-IR could be a possible mediator to improve approaches of stem cells in the field of regenerative medicine.

The long term effects of intrascrotal low dose and high dose N-acetylcysteine on testis damage in rat model of testicular torsion

2020 ◽  
Vol 55 (4) ◽  
pp. 672-680 ◽  
Author(s):  
Tuğba Acer-Demir ◽  
Mirhüseyn Mammadov ◽  
Pınar Öcbe ◽  
Asyanur Çoruhlu ◽  
Dicle Coşkun ◽  
...  
Keyword(s):  
Rat Model ◽  
Testicular Torsion ◽  
Low Dose ◽  
High Dose ◽  
Long Term Effects

Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study

2013 ◽  
Vol 52 (4) ◽  
pp. 451-461 ◽  
Author(s):  
Mayur V. Bakshi ◽  
Zarko Barjaktarovic ◽  
Omid Azimzadeh ◽  
Stefan J. Kempf ◽  
Juliane Merl ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Low Dose ◽  
Neonatal Mouse ◽  
Mouse Heart ◽  
Long Term Effects ◽  
Proteomic Study
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