Delayed Progression of Chronic Renal Failure: A Prospective Controlled Trial with a Low Protein Diet Supplemented by Keto Acids

2015 ◽  
pp. 78-86 ◽  
Author(s):  
Norbert Gretz ◽  
Manfred Strauch
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Controlled Trial ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Keto Acids

scholarly journals Insulin-like growth factor-1 and its binding proteins during a low-protein diet in chronic renal failure.

1995 ◽  
Vol 6 (5) ◽  
pp. 1427-1433
Author(s):  
D Fouque ◽  
Y Le Bouc ◽  
M Laville ◽  
F Combarnous ◽  
M O Joly ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Protein Intake ◽  
Binding Proteins ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Insulin Like Growth Factor ◽  
Low Protein ◽  
Keto Acids

The effects of a low-protein diet on the serum insulin-like growth factor (IGF)-1 and IGF binding proteins (IGFBP) were investigated during a 3-month controlled study in 12 adult chronic renal failure patients. Six patients were randomly supplemented with keto acids (Cetolog, Clintec, Velizy, France). Protein intake was prescribed so that both groups were isonitrogenous. Dietary survey included a monthly 3-day food record and a 24-h urinary urea measurement. After a 4- to 6-wk equilibrium period (1.11 g of protein, 32 kcal/kg body wt per day), patients reduced their protein intake to 0.71 g protein/kg body wt per day. Energy intake was kept constant (31 kcal/kg body wt per day) during the 3-month period. Serum IGF-1 levels were in normal range and, for 11 of the 12 patients, were correlated with the GFR (P = 0.01). These serum IGF-1 values did not decrease after reducing the protein intake. By Western ligand blotting, serum IGFBP1, IGFBP2, and IGFBP4 levels were significantly higher than normal adults, whereas the IGFBP3 level was not increased. IGFBP were not modified when protein intake was reduced. The IGFBP1 level was elevated despite a normal insulin level. IGFBP4 changes were inversely correlated with IGF-1 variations. There was no difference between groups receiving or not receiving the keto acids. Thus, in adult chronic renal failure, reducing protein intake by 40% did not modify the growth hormone/IGF-1/IGFBP axis.

Effect of Low-Protein Diet Supplemented with Keto Acids on Progression of Disease in Patients with Chronic Renal Failure

Nephron ◽  
2000 ◽  
Vol 84 (3) ◽  
pp. 288-289 ◽  
Author(s):  
M. Deniz Ayli ◽  
Meltem Ayli ◽  
Cüneyt Ensari ◽  
Fahri Mandiroglu ◽  
Murat Allioglu
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Keto Acids ◽  
Progression Of Disease

Comparison of a Vegetable-Based (Soya) and an Animal-Based Low-Protein Diet in Predialysis Chronic Renal Failure Patients

Nephron ◽  
1998 ◽  
Vol 79 (2) ◽  
pp. 173-180 ◽  
Author(s):  
N. Soroka ◽  
D.S. Silverberg ◽  
M. Greemland ◽  
Y. Birk ◽  
M. Blum ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Predialysis Chronic Renal Failure

scholarly journals Survival on dialysis among chronic renal failure patients treated with a supplemented low-protein diet before dialysis.

1995 ◽  
Vol 6 (5) ◽  
pp. 1379-1385
Author(s):  
J Coresh ◽  
M Walser ◽  
S Hill
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Mortality Rate ◽  
Serum Creatinine ◽  
Dietary Treatment ◽  
Mortality Rates ◽  
Protein Restriction ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

Concerns have been raised about the possibility of protein restriction resulting in malnutrition and poor subsequent survival on dialysis. However, no studies have examined patients treated with protein restriction to determine their subsequent survival on dialysis. This study prospectively monitored 67 patients with established chronic renal failure (mean initial serum creatinine of 4.3 mg/dL) who were treated with a very low-protein diet (0.3 g/kg per day) supplemented with either essential amino acids or a ketoacid-amino acid mixture and observed closely for clinical complications. Forty-four patients required dialysis. Once dialysis was started, dietary treatment was no longer prescribed. The cumulative mortality rate during the first 2 yr after starting dialysis was 7% (95% confidence interval, 0 to 16%). During this period, only two deaths occurred compared with 11.5 deaths expected on the basis of national mortality rates adjusted for age, sex, race, and cause of renal disease (P = 0.002). However, the protective effect was limited to the first 2 yr on dialysis. Thereafter, mortality rates increased, resulting in a total of 10 deaths during 96.4 person-years of follow-up, which was not significantly lower than the 14.9 deaths expected (P = 0.25). Extrapolation of sequential serum creatinine measurements made before dietary treatment suggests that the improved survival cannot be due to the early initiation of dialysis. Although the lack of an internal control group and data on dialysis lends uncertainty, the large difference in mortality rate between these patients and the nationwide experience indicates that protein restriction and close clinical monitoring predialysis does not worsen and may substantially improve survival during the first 2 yr on dialysis. These findings point out the importance of studying predialysis treatments as a means for lowering mortality on dialysis.

Low-protein diet in children with chronic renal failure?1-year results

1991 ◽  
Vol 5 (4) ◽  
pp. 496-500 ◽  
Author(s):  
Anne-Margret Wingen ◽  
Claudia Fabian-Bach ◽  
Otto Mehls
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

Low-protein diet and chronic renal failure

The Lancet ◽  
1991 ◽  
Vol 338 (8764) ◽  
pp. 442-444 ◽  
Author(s):  
Giuliano Barsotti ◽  
Sergio Giovannetti ◽  
N. Gretz ◽  
M. Strauch ◽  
Francesco Locatelli ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein
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