Clinical and Prognostic Relevance of the Kiel Classification System

2015 ◽  
pp. 153-165
Author(s):  
Kiel Lymphoma Study Group
Keyword(s):  
Classification System ◽  
Prognostic Relevance ◽  
Kiel Classification

Prognostic relevance of the novel TNM-classification system for neuroendocrine tumors of foregut origin

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 15147-15147
Author(s):  
U. Pape ◽  
H. Jann ◽  
U. Berndt ◽  
B. Wiedenmann
Keyword(s):  
Multivariate Analysis ◽  
Neuroendocrine Tumors ◽  
Classification System ◽  
Tnm Classification ◽  
Prognostic Significance ◽  
Stage Iv ◽  
Stage I ◽  
Stage Iii ◽  
Primary Tumors ◽  
Prognostic Relevance

15147 Background: Until recently no TNM-classification existed for neuroendocrine tumors (NET) of the gastroenteropancreatic system. In 2006 Rindi et al. proposed a new TNM-classification system for foregut-NET of gastric, duodenal and pancreatic origin. The present study validates prognostic significance of the new TNM-classification in a cohort from a German referral center. Methods: The case files of 193 patients with histologically proven foregut NET were analyzed retrospectively. Patients were classified according to Capella (1995) and the WHO (2000) and to the new TNM-classification. Uni- and multivariate analysis was performed using log-rank and Cox regression methods. Results: Primary tumors localization was gastric (n=48), duodenal (23) and pancreatic (122); 35 patients (18%) died during the observation period. Overall 5- and 10-year survival rates (YSR) were 76% and 65% resp., while 5- and 10-YSR according to NET-related deaths (74% of all deaths, 26/35) were 83% and 74% resp.. The classifications by Capella and the WHO significantly discriminated between low and high grade malignant NET (p<0,001 and 0,002 resp.), but did not allow further prognostic differentiation. In contrast, the newly proposed TNM-classification system was able to significantly differentiate stage IV NET from all other stages (I vs. IV p=0,001; II vs. IV p=0,001; III vs. IV p=0,008) as well as stage III from stage I NET (p=0,038). Furthermore, the new classification system which includes a grading system according to the mitotic index (Ki67-index; G1 <3%, G2 3–20%, G3 >20%) was also able to significantly distinguish all three groups from each other (G1 vs. G3 p<0,001; G2 vs. G3 p<0,001). On multivariate analysis stage I and II as well as stage III-NET had a decreased hazard ratio (HR) when compared to stage IV-NET (I/II: HR 0,094, p=0,003; III: HR 0,38, p=0,096). In the same model G1 and G2-NET were associated with an decreased HR as compared to G3-NET (G1: HR 0,05, p=0,01; G2: HR 0,20, p=0,002). Conclusions: Here we demonstrate prognostic relevance of the newly proposed TNM-classification system for foregut-NET with statistical significance which therefore provides a new and powerful tool for future classification of NET. No significant financial relationships to disclose.

Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors

Cancer ◽  
2008 ◽  
Vol 113 (2) ◽  
pp. 256-265 ◽  
Author(s):  
Ulrich‐Frank Pape ◽  
Henning Jann ◽  
Jacqueline Müller‐Nordhorn ◽  
Angelina Bockelbrink ◽  
Uta Berndt ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Classification System ◽  
Tnm Classification ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Prognostic Relevance

International Research and Variation in Views of Ethnicity

2012 ◽  
Vol 2 (2) ◽  
pp. 66-72
Author(s):  
Ella Inglebret ◽  
Amy Skinder-Meredith ◽  
Shana Bailey ◽  
Carla Jones ◽  
Ashley France
Keyword(s):  
United States ◽  
Classification System ◽  
International Research ◽  
The United States ◽  
Research Articles ◽  
Journal Articles ◽  
Research Participants ◽  
The Past ◽  
International Scale ◽  
Publication Patterns

The authors in this article first identify the extent to which research articles published in three American Speech-Language-Hearing Association (ASHA) journals included participants, age birth to 18 years, from international backgrounds (i.e., residence outside of the United States), and go on to describe associated publication patterns over the past 12 years. These patterns then provide a context for examining variation in the conceptualization of ethnicity on an international scale. Further, the authors examine terminology and categories used by 11 countries where research participants resided. Each country uses a unique classification system. Thus, it can be expected that descriptions of the ethnic characteristics of international participants involved in research published in ASHA journal articles will widely vary.

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