Immunoregulatory Mechanisms in the Uterus and Survival of the Fetus1

1985 ◽  
pp. 44-53 ◽  
Author(s):  
David A. Clark ◽  
Renata M. Slapsys
Keyword(s):  
Immunoregulatory Mechanisms

scholarly journals The Role of NKT Cells in Glioblastoma

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1641
Author(s):  
Emily E. S. Brettschneider ◽  
Masaki Terabe
Keyword(s):  
Immune Responses ◽  
Cell Activity ◽  
Nkt Cells ◽  
Type I ◽  
Type Ii ◽  
Central Nervous System Diseases ◽  
Nkt Cell ◽  
Lipid Antigens ◽  
Immunoregulatory Mechanisms

Glioblastoma is an aggressive and deadly cancer, but to date, immunotherapies have failed to make significant strides in improving prognoses for glioblastoma patients. One of the current challenges to developing immunological interventions for glioblastoma is our incomplete understanding of the numerous immunoregulatory mechanisms at play in the glioblastoma tumor microenvironment. We propose that Natural Killer T (NKT) cells, which are unconventional T lymphocytes that recognize lipid antigens presented by CD1d molecules, may play a key immunoregulatory role in glioblastoma. For example, evidence suggests that the activation of type I NKT cells can facilitate anti-glioblastoma immune responses. On the other hand, type II NKT cells are known to play an immunosuppressive role in other cancers, as well as to cross-regulate type I NKT cell activity, although their specific role in glioblastoma remains largely unclear. This review provides a summary of our current understanding of NKT cells in the immunoregulation of glioblastoma as well as highlights the involvement of NKT cells in other cancers and central nervous system diseases.

scholarly journals Distinct Roles for CD4+ Foxp3+ Regulatory T Cells and IL-10–Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by Leishmania donovani

2018 ◽  
Vol 201 (11) ◽  
pp. 3362-3372 ◽  
Author(s):  
Patrick T. Bunn ◽  
Marcela Montes de Oca ◽  
Fabian de Labastida Rivera ◽  
Rajiv Kumar ◽  
Susanna S. Ng ◽  
...  
Keyword(s):  
T Cells ◽  
Visceral Leishmaniasis ◽  
Regulatory T Cells ◽  
Leishmania Donovani ◽  
Immunoregulatory Mechanisms

Immunoregulatory Effects of Stored Red Blood Cells

Hematology ◽  
2011 ◽  
Vol 2011 (1) ◽  
pp. 466-469 ◽  
Author(s):  
Karina Yazdanbakhsh ◽  
Weili Bao ◽  
Hui Zhong
Keyword(s):  
Red Blood Cells ◽  
Patient Outcomes ◽  
Clinical Studies ◽  
Blood Cells ◽  
Immunomodulatory Effects ◽  
Tissue Microenvironment ◽  
High Concentrations ◽  
Transfusion Reactions ◽  
Immunoregulatory Mechanisms

Abstract Some clinical studies have identified potential adverse patient outcomes associated with RBC storage length. This may in part be due to the release of potentially hazardous bioactive products that accumulate during storage and are delivered at high concentrations during transfusion. In this situation, a proinflammatory tissue microenvironment may be established that can alter immunoregulatory mechanisms. This review highlights some of the potential immunomodulatory effects of stored RBCs that may be responsible for adverse transfusion reactions.

scholarly journals Hepatoprotective Effects of Total Triterpenoids and Total Flavonoids fromVitis viniferaL against Immunological Liver Injury in Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Tao Liu ◽  
Jun Zhao ◽  
Long Ma ◽  
Yusong Ding ◽  
Deqi Su
Keyword(s):  
Liver Injury ◽  
Folk Medicine ◽  
Liver Homogenate ◽  
Protective Role ◽  
Total Flavonoids ◽  
Sod Activity ◽  
Mda Content ◽  
Hepatoprotective Effects ◽  
Th1 Cytokines ◽  
Immunoregulatory Mechanisms

Suosuo grape (the fruits ofVitis viniferaL) has been used for prevention and treatment of liver diseases in Uighur folk medicine in China besides its edible value. In this study, the hepatoprotective effects of total triterpenoids (VTT) and total flavonoids (VTF) from Suosuo grape were evaluated in Bacille-Calmette-Guerin- (BCG-) plus-lipopolysaccharide- (LPS-) induced immunological liver injury (ILI) in mice. Various dose groups (50, 150, and 300 mg/kg) of VTT and VTF alleviated the degree of liver injury of ILI mice, effectively reduced the BCG/LPS-induced elevated liver index and spleen index, hepatic nitric oxide (NO), and malondialdehyde (MDA) content, increased liver homogenate alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and restored hepatic superoxide dismutase (SOD) activity in ILI mice. VTT and VTF also significantly inhibited intrahepatic expression of Th1 cytokines (IFN-γand IL-2) in ILI mice and increased intrahepatic expression of Th2 cytokines (IL-4 and IL-10). Moreover, the increased Bax/Bcl-2 ratio was significantly downregulated by VTT and VTF in liver tissue of ILI mice. These results are comparable to those of biphenyl dicarboxylate (DDB, the reference hepatoprotective agent) and suggest that VTT and VTF play a protective role against immunological liver injury, which may have important implications for our understanding of the immunoregulatory mechanisms of this plant.

IMMUNOREGULATORY MECHANISMS IN CYCLOSPORINE-TREATED RENAL ALLOGRAFT RECIPIENTS

1987 ◽  
Vol 43 (2) ◽  
pp. 205-210 ◽  
Author(s):  
RONALD H. KERMAN ◽  
STUART M. FLECHNER ◽  
CHARLES T. VAN BUREN ◽  
MARC I. LORBER ◽  
BARRY D. KAHAN
Keyword(s):  
Renal Allograft ◽  
Immunoregulatory Mechanisms
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