Airway Inflammation during Antigen-Induced Late Bronchial Obstruction

2015 ◽  
pp. 48-55 ◽  
Author(s):  
W. M. Abraham ◽  
A. P. Perruchoud ◽  
M. W. Sielczak ◽  
L. D. Yerger ◽  
J. S. Stevenson
Keyword(s):  
Airway Inflammation ◽  
Bronchial Obstruction

scholarly journals State of respiratory function and features of airway inflammation in children with asthma combined with gastroesophageal reflux disease

2021 ◽  
pp. 62-65
Author(s):  
A.A. Buratynska ◽  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Lung Function ◽  
Gastroesophageal Reflux ◽  
Airway Inflammation ◽  
Reflux Disease ◽  
Induced Sputum ◽  
Bronchial Obstruction ◽  
Healthy Children ◽  
Children With Asthma ◽  
The Difference

The prevalence of gastroesophageal reflux disease (GERD) in children with asthma ranges from 32% to 80%. The intensity of respiratory symptoms, bronchial obstruction are more pronounced in children with asthma combined with GERD than in children with isolated asthma. However, there are limited and conflicting data on the difference between the induced sputum in asthmatic children with or without GERD. Purpose — to examine the status of lung function and features of airway inflammation in children with asthma combined with gastroesophageal reflux disease. Materials and methods. Sixty-seven children ages 6–17 years with moderate asthma and 30 healthy children ages 6–17 years were observed. They were assigned to three groups: group 1 (32 children with isolated asthma), and group 2 (35 children with asthma and GERD) and group 3 (30 healthy children). All children included in the study were identical in age and gender. Clinical assessment, spirometry with test of reversibility of airway obstruction, and cytological analysis of induced sputum samples were performed on all patients. Upper gastrointestinal endoscopy was done in the asthmatic groups. Results. There were 10 (28.57%) children in the 2nd group with first degree obstructive spirometry pattern and none in the 1st group of children. First degree restrictive spirometry pattern was more significant observed in the 1st group of children — 10 (31.25%) than in the 2nd group of children — 2 (5.71%) (OR, CI 95% 7.50 (1.50–37.57)). In the 2nd group of children, induced sputum had a significantly higher number of neutrophils, lymphocytes and macrophages compared to the 3rd group (p<0.05). Also the difference between these parameters were significant compared to the 1st group of children. The number of induced sputum epithelial cells in 2nd group was significantly less than in 1st group of children. Conclusions. GERD negatively affects the parameters of lung function in children with asthma. Airway inflammation in children with asthma combined with GERD appears to be more significant compared to isolated asthma. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of an participating institution. The informed consent of the child's parents was obtained from the studies. No conflict of interest was declared by the authors. Key words: asthma, gastroesophageal reflux disease, children, spirometry, induced sputum.

Attenuated allergic airway inflammation in Cd39-/- mice

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
M Idzko ◽  
K Ayata ◽  
T Müller ◽  
T Dürk ◽  
M Grimm ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation

Extracellular ATP triggers and maintains airway inflammation in human and murine models of asthma by activating dendritic cells

Pneumologie ◽  
2008 ◽  
Vol 62 (S 2) ◽  
Author(s):  
M Idzko ◽  
D Ferrari ◽  
F Di Virgilio ◽  
S Sorichter ◽  
B Lambrecht ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Extracellular Atp ◽  
Murine Models

Intensive care of a complicated form of asthmatic status (clinical case)

2019 ◽  
Vol 2 (31) ◽  
pp. 46-51
Author(s):  
D. A. Temerov ◽  
L. V. Vorobyova ◽  
S. V. Vyzhevsky ◽  
S. B. Savchenkov ◽  
Yu. V. Marchenkov
Keyword(s):  
Clinical Case ◽  
Mixture Distribution ◽  
Severe Pneumonia ◽  
Control Mode ◽  
Respiratory Support ◽  
Oxygen Mixture ◽  
Bronchial Obstruction ◽  
Optimal Regime ◽  
Pulmonary Barotrauma ◽  
Airway Patency

The article presents a clinical case of successful treatment of a patient with prolonged asthmatic status. The pathogenesis of purulent-septic and other life-threatening complications developing as a result of the above critical condition is described. The positive effect of a differentiated approach in conducting respiratory support depending on the stage of the disease is justified: at the beginning, when airway obstruction is in the foreground, and in the future, when restrictive respiratory disorders develop. When conducting respiratory support, the most reasonable methods for ensuring airway patency were selected. The necessity of neurovegetative blockade and myoplegia for the prevention of pulmonary barotrauma during respiratory support by aggressive ventilation modes and with the goal of antihypoxic protection of the brain is emphasized. During the treatment of the patient, it was confirmed that the optimal regime for obstruction of the bronchi is forced volume-cyclic ventilation of the lungs to provide the necessary minute volume of breathing, and in severe pneumonia, in the case of relief of bronchial obstruction, respiratory support is carried out in pressure control mode for better air-oxygen mixture distribution in the airways. The need for early tracheostomy and daily therapeutic fibrobronchoscopy to ensure airway patency and treat pneumonia has been confirmed.

Dynamic indicators of the airway inflammation activity in teenagers with bronchial asthma

2017 ◽  
Vol 82 (2) ◽  
pp. 102-105
Author(s):  
O.K. Koloskova ◽  
◽  
O.O. Shahova ◽  
S.I. Tarnavska ◽  
N.O. Shevchenko ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Bronchial Asthma ◽  
Dynamic Indicators

RESPIRATORY TUBERCULOSIS AND CHRONIC OBSTRUCTIVE LUNG DISEASE - FEATURES OF THE COMORBIDE STATE

2019 ◽  
Author(s):  
Anna Viktorovna Katicheva ◽  
Nikolai Andreyevich Brazhenko ◽  
Olga Nikolaevna Brazhenko ◽  
Anna Georgievna Chuikova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Rapid Development ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Bronchial Obstruction ◽  
Obstructive Pulmonary Disease ◽  
Diffusion Capacity ◽  
Cardiovascular Pathology ◽  
Systemic Arterial Hypertension

In modern conditions, chronic tobacco intoxication and chronic obstructive pulmonary disease are widespread and affect the health and life expectancy of patients. Among patients with tuberculosis, chronic tobacco intoxication and COPD are also widespread. Against the background of smoking and chronic obstructive pulmonary disease in patients with tuberculosis of the respiratory system, bronchial obstruction, hypoxemia, impaired capillary pulmonary blood flow, and a decrease in the diffusion capacity of the lungs are determined. A comorbid state is accompanied by the development of oxidative stress, systemic inflammation, endothelial dysfunction. Such changes in combination with dyslipidemia contribute to the development of multifocal atherogenesis, systemic arterial hypertension and the rapid development of cardiovascular pathology

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