Perinatal Hemodynamic Events and Neurologic Development

2015 ◽  
pp. 259-264
Author(s):  
Hans C. Lou
Keyword(s):  
Neurologic Development

Just Say No!

PEDIATRICS ◽  
1990 ◽  
Vol 86 (4) ◽  
pp. 624-624
Author(s):  
JOHN M. FREEMAN
Keyword(s):  
Febrile Seizure ◽  
Febrile Seizures ◽  
National Institutes Of Health ◽  
Consensus Development ◽  
Consensus Development Conference ◽  
Focal Seizures ◽  
The Family ◽  
History Of ◽  
Neurologic Development

A seizure, even a febrile seizure, is terrifying to the family. Seeking reassurance that their child will not die and does not have epilepsy, parents turn to their physician. What is he or she to do? Often the physician prescribes medication "to prevent further seizures" and then reassures the family that the child will be fine if the medicine is given daily as directed. Both the recommendation and the reassurance are wrong. A Consensus Development Conference on Febrile Seizures held by the National Institutes of Health in 19801 concluded that they would only "consider" anticonvulsant prophylaxis when the child (1) had abnormal neurologic development, (2) had long or focal seizures, (3) had more than two seizures in 24 hours, (4) had a history of nonfebrile seizures in parent or sibling, or (5) was younger than 1 years of age.

scholarly journals Vitamin B12-responsive neonatal megaloblastic anemia and homocystinuria with associated reduced methionine synthase activity

Blood ◽  
1987 ◽  
Vol 69 (4) ◽  
pp. 1128-1133 ◽  
Author(s):  
LJ Hallam ◽  
M Sawyer ◽  
AC Clark ◽  
MB Van der Weyden
Keyword(s):  
Vitamin B12 ◽  
Developmental Delay ◽  
Genetic Heterogeneity ◽  
Megaloblastic Anemia ◽  
Methylmalonic Aciduria ◽  
Methionine Synthase ◽  
Cultured Fibroblasts ◽  
Neurologic Recovery ◽  
Neurologic Development ◽  
Growth Requirement

Abstract We present findings on an infant with neonatal megaloblastic anemia, homocystinuria, and neurologic dysfunction that included developmental delay and tonic seizures. There was no methylmalonic aciduria. Cyanocobalamin therapy was accompanied by complete hematologic and neurologic recovery, diminished homocystine excretion, and subsequently normal neurologic development. Cultured fibroblasts and lymphoblasts showed a reduced methionine synthase activity and a growth requirement for methionine. Cobalamin incorporation by the patient's lymphoblasts was normal, but the proportion of cellular methylcobalamin in the patient's lymphoblasts and fibroblasts were markedly reduced and that of adenosylcobalamin normal. The reduced methionine synthase activity was independent of assay reducing (thiol) conditions, but normal levels of activity accompanied culture of the patient's lymphoblasts in medium with markedly increased cobalamin concentration. The characteristics of the reduced methionine synthase of our patient differ significantly from that of the previously described infant with cobalamin E disease and suggest that genetic heterogeneity may characterize this mutation.

Developmental Enamel Defects in Primary Teeth in Children with Cerebral Palsy, Mental Retardation, or Hearing Defects: A Review

1989 ◽  
Vol 3 (2) ◽  
pp. 132-142 ◽  
Author(s):  
M. Bhat ◽  
K.B. Nelson
Keyword(s):  
Cerebral Palsy ◽  
Mental Retardation ◽  
Primary Teeth ◽  
Viral Infections ◽  
Dental Enamel ◽  
Tooth Germ ◽  
Developmental Defects ◽  
Enamel Defects ◽  
Children With Cerebral Palsy ◽  
Neurologic Development

Developmental enamel defects in primary teeth have been found at least twice as frequently in children with cerebral palsy or mental retardation as in control children, and frequently also in children with sensori-neural hearing deficits. The developing tooth germ is sensitive to a range of systemic disturbances, some of which may also affect neurologic development. Because the enamel cannot recover once it is damaged, it may provide a repository of information on the timing and nature of insults potentially affecting other ectodermally derived structures, including the brain. This paper reviews the literature on developmental defects of enamel in primary teeth, asking whether these might be useful as biological markers of the timing and in some cases the nature of insults. Among systemic factors related to development of enamel that might also have implications for neurologic development are certain genetic disorders including tuberous sclerosis, premature birth, neonatal nutritional disturbances (especially hypocalcemia), viral infections (such as rubella and cytomegalovirus during gestation), thyroid disorders, and maternal diabetes. It is concluded that further research is warranted concerning whether developmental defects of dental enamel can be useful markers for the timing of intra-uterine or perinatal events associated with certain neurologic and sensory disorders of children.

Peri- and Intraventricular Cerebral Sonography in Second- and Third-Trimester High-Risk Fetuses: A Comparison With Neonatal Ultrasound and Relation to Neurologic Development

2004 ◽  
Vol 59 (2) ◽  
pp. 74-75
Author(s):  
M. R. van Gelder-Hasker ◽  
G. van Wezel-Meijler ◽  
L. de Groot ◽  
H. P. van Geijn ◽  
J. I. P. de Vries
Keyword(s):  
High Risk ◽  
Third Trimester ◽  
Neurologic Development

Neurologic development of the newborn and young child in relation to maternal thyroid function

2000 ◽  
Vol 89 (3) ◽  
pp. 291-295 ◽  
Author(s):  
BJ Smit ◽  
JH Kok ◽  
T Vulsma ◽  
JM Briët ◽  
K Boer ◽  
...  
Keyword(s):  
Young Child ◽  
Thyroid Function ◽  
Neurologic Development ◽  
Maternal Thyroid

Continuous Insulin Infusion: Promoting Growth in Low Birth Weight Infants

2001 ◽  
Vol 20 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Rachel Zylberberg ◽  
Mel Pepper
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Insulin Infusion ◽  
Low Birth Weight Infants ◽  
Priority List ◽  
Policies And Procedures ◽  
Management Modality ◽  
System Requirements ◽  
Neurologic Development ◽  
Continuous Insulin Infusion

Development of improved technologies in neonatal care has yielded increasing numbers of surviving low birth weight (LBW) infants who have challenged methods of supportive care. As researchers and practitioners have focused on respiratory, cardiac, and other body system requirements, nutritional support has been low on the priority list. Support for growth and maximized neurologic development, rather than simply for survival, has been the challenge in care of small and sick newborns. Use of insulin to enhance glucose tolerance in LBW infants, and thereby maximize growth, is a management modality that can be initiated early in the infant’s course and is facilitated by implementation of clear and consistent policies and procedures. Continuous insulin infusions have been demonstrated to enhance glucose uptake and utilization—facilitating neonatal growth and in turn enhancing brain growth and developmental outcome.

Neurologic development examination in normal preschool children aged 3 to 7 year

1976 ◽  
Vol 89 (2) ◽  
pp. 322
Author(s):  
A.B. Lefevre ◽  
A.J. Diament ◽  
M.I. Valente ◽  
B.H.W. Ferreira ◽  
A. D'Onghia ◽  
...  
Keyword(s):  
Preschool Children ◽  
Neurologic Development

scholarly journals Duplication ofHEY2in cardiac and neurologic development

2015 ◽  
Vol 167 (9) ◽  
pp. 2145-2149 ◽  
Author(s):  
Valerie K. Jordan ◽  
Jill A. Rosenfeld ◽  
Seema R. Lalani ◽  
Daryl A. Scott
Keyword(s):  
Neurologic Development
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