The Effect of Prostacyclin or Iloprost on Eicosanoid Formation and the Leukopenia of Endotoxin Shock

2015 ◽  
pp. 202-206
Author(s):  
E. F. Smith ◽  
G. E. Tempel ◽  
W. C. Wise ◽  
P. V. Halushka ◽  
J. A. Cook
Keyword(s):  
Endotoxin Shock ◽  
Eicosanoid Formation

scholarly journals C1 Inhibitor Prevents Endotoxin Shock Via a Direct Interaction with Lipopolysaccharide

2003 ◽  
Vol 171 (5) ◽  
pp. 2594-2601 ◽  
Author(s):  
Dongxu Liu ◽  
Shenghe Cai ◽  
Xiaogang Gu ◽  
Jennifer Scafidi ◽  
Xiao Wu ◽  
...  
Keyword(s):  
Direct Interaction ◽  
Endotoxin Shock ◽  
C1 Inhibitor

Interaction of Ionizing Radiation and E. Coli Endotoxin I. Effect of Radiation on Endotoxin Shock

1968 ◽  
Vol 133 (5) ◽  
pp. 387-390
Author(s):  
James A. Vick ◽  
Richard DeGraaf ◽  
Charles C. Berdjis
Keyword(s):  
Ionizing Radiation ◽  
Endotoxin Shock ◽  
E Coli

Beneficial effects of hypertonic saline/dextran on early survival in porcine endotoxin shock

2005 ◽  
Vol 49 (8) ◽  
pp. 1124-1134 ◽  
Author(s):  
A. Somell ◽  
A. Sollevi ◽  
A. Suneson ◽  
L. Riddez ◽  
H. Hjelmqvist
Keyword(s):  
Hypertonic Saline ◽  
Endotoxin Shock ◽  
Beneficial Effects ◽  
Early Survival

scholarly journals Beneficial haemodynamic effect of indomethacin during endotoxin shock in anaesthetized pigsputative involvement of nitric oxide?

1995 ◽  
Vol 4 (2) ◽  
pp. 117-123 ◽  
Author(s):  
T. Mózes ◽  
E. M. van Gelderen ◽  
E. J. Mylecharane ◽  
P. R. Saxena
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Beneficial Effect ◽  
Endotoxic Shock ◽  
Haemodynamic Effect ◽  
Experimental Period ◽  
Endotoxin Shock ◽  
Arterial Blood ◽  
Imminent Death ◽  
Beneficial Haemodynamic Effect

Endotoxin shock was induced in 31 anaesthetized pigs by infusion of 5 μg/kg of Escbeicbia coli endotoxin (LPS) over 60 min into the superior mesenteric artery. Fifteen of these pigs died within 30 min of the start of LPS infusion whereas the remaining 16 survived the experimental period of 2 h. In a group of nine pigs indomethacin (2 mg/kg, i.v.)was inected 20–25 rain after the start of LPS infusion at which time mean arterial blood pressure (MABP) had decreased below 40 mmHg indicating imminent death. Indomethacin immediately reversed the hypotension. In another group of five pigs, NG-nitro L-arginine-methyl ester (L-NAME, 1 and 3 mg/kg)was iniected 10 and 5 min, respectively, before the expected death without any beneficial effect on the hypotension. Three rain after the last dose of L-NAME, indomethacin (2 mg/kg, i.v.) was iniected. In three animals the hypotension was reserved by indomethacin, although this beneficial effect was delayed in comparison with the LP-Streated group not receiving L-NAME. Four pigs were pretreated with L-NAME, 3 mg/kg, i.v., 10 min prior to LPS infusion. All pretreated animals tended to die within 30 min of the start of the LPS infusion. Five rain before the expected death (20–25 rain after the start of LPS infusion) indomethacin (2 mg/kg) was inected. In three of these animals indomethacin reversed hypotenston and prevented death. Interestingly, this rise in the MABP developed very slowly. These results suggest that the beneficial effect of indomethacin in endotoxin shock might be related partially to interference with nitric oxide, which is not the only factor determining blood pressure levels during endotoxic shock.

EXTRACELLULAR FLUID SHIFTS IN ENDOTOXIN SHOCK

1967 ◽  
Vol 7 (Sup 6) ◽  
pp. 884-888 ◽  
Author(s):  
BENJAMIN F. RUSH ◽  
ROBERT SPARKS
Keyword(s):  
Extracellular Fluid ◽  
Endotoxin Shock ◽  
Fluid Shifts

Influence of Aldosterone and Angiotensin II on Endotoxin Shock in the Primate.

1963 ◽  
Vol 112 (3) ◽  
pp. 795-799 ◽  
Author(s):  
W. W. Spink ◽  
J. A. Vick ◽  
J. C. Melby ◽  
J. Finstad
Keyword(s):  
Angiotensin Ii ◽  
Endotoxin Shock
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