Peripheral Panretinal Photocoagulation and Perfluoropropane/Air Mixture in Vitreoretinal Surgery for Proliferative Vitreoretinopathy

2015 ◽  
pp. 194-199
Author(s):  
Yale Fisher ◽  
Donald Shafer ◽  
Jeffrey Shakin ◽  
Lawrence A. Yannuzzi ◽  
John Sorenson
Keyword(s):  
Proliferative Vitreoretinopathy ◽  
Vitreoretinal Surgery ◽  
Panretinal Photocoagulation

scholarly journals Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Claudio Azzolini ◽  
Ilaria Stefania Pagani ◽  
Cristina Pirrone ◽  
Davide Borroni ◽  
Simone Donati ◽  
...  
Keyword(s):  
Proliferative Vitreoretinopathy ◽  
Vitreoretinal Surgery ◽  
Pcr Analysis ◽  
P53 Family ◽  
Healthy Human ◽  
Epiretinal Membranes ◽  
Genetic Pathways ◽  
Variable Expression ◽  
Basal Expression ◽  
Novel Approach

Introduction. Proliferative vitreoretinopathy (PVR) is a severe inflammatory complication of retinal detachment. Pathological epiretinal membranes grow on the retina surface leading to contraction, and surgery fails in 5% to 10% of the cases. We evaluated the expression of VEGF-A, Otx1, Otx2, Otx3, and p53 family members from PVR specimens to correlate their role in inducing or preventing the pathology.Methods. Twelve retinal samples were taken from patients affected by PVR during therapeutic retinectomies in vitreoretinal surgery. Gene expression was evaluated using quantitative real-time reverse transcriptase PCR analysis and immunohistochemistry, using four healthy human retinae as control.Result. Controls showed basal expression of all genes. PVR samples showed little or no expression of Otx1 and variable expression of VEGF-A, Otx2, Otx3, p53, and p63 genes. Significant correlation was found among VEGF-A, Otx2, p53, and p63 and between Otx1 and Otx3.Conclusions. Otx homeobox, p53 family, and VEGF-A genes are expressed in PVR human retina. We individuated two possible pathways (VEGF-A, Otx2, p53, p63 and Otx1 and Otx3) involved in PVR progression that could influence in different manners the course of the pathology. Individuating the genetic pathways of PVR represents a novel approach to PVR therapies.

scholarly journals Vitreoretinal Surgery and Panretinal Photocoagulation in a Patient with Multiple Large Retinal Capillary Hemangiomas (von Hippel-Lindau Disease): A Novel Approach

2019 ◽  
Vol 10 (3) ◽  
pp. 327-333 ◽  
Author(s):  
Guilherme Sturzeneker ◽  
André Maia ◽  
Melina Morales ◽  
Rubens N. Belfort
Keyword(s):  
Pars Plana Vitrectomy ◽  
Vitreoretinal Surgery ◽  
Internal Limiting Membrane ◽  
Positive Outcome ◽  
Intravitreal Injections ◽  
Panretinal Photocoagulation ◽  
Von Hippel Lindau ◽  
Retinal Capillary ◽  
Pars Plana ◽  
Vhl Disease

The authors present a novel surgical approach for the treatment of retinal capillary hemangiomas (RCHs) secondary to von Hippel-Lindau (VHL) disease. This is a case report of a 23-year-old male patient with VHL that presented with multiple large RCHs and a thick epiretinal membrane (ERM) in his left eye, with best-corrected visual acuity (BCVA) of 20/80. This condition was surgically addressed with 23-gauge pars plana vitrectomy, ERM and internal limiting membrane peeling, and panretinal photocoagulation. Three monthly intravitreal injections of bevacizumab were administered after surgery. In a 14-month follow-up period, hemangiomas have regressed after laser therapy, macular anatomy has improved, retina remained completely attached, and there has been no development of new tumors or proliferative vitreoretinopathy. The patient achieved a BCVA of 20/40 in the treated eye. Panretinal photocoagulation combined with pars plana vitrectomy may be useful to reduce development of new capillary hemangiomas and reduce overall occurrence of complications in patients with VHL disease. Postoperative intravitreal injections of bevacizumab may have a role in this positive outcome.

Panretinal photocoagulation aggravates experimental proliferative vitreoretinopathy

1990 ◽  
Vol 228 (5) ◽  
pp. 461-466 ◽  
Author(s):  
Peep V. Algvere ◽  
Kerstin Halln�s ◽  
Eva Dafg�rd ◽  
Anders H��g
Keyword(s):  
Proliferative Vitreoretinopathy ◽  
Panretinal Photocoagulation

Perfluoropropane Gas, Modified Panretinal Photocoagulation, and Vitrectomy in the Management of Severe Proliferative Vitreoretinopathy

1988 ◽  
Vol 106 (9) ◽  
pp. 1255-1260 ◽  
Author(s):  
Y. L. Fisher ◽  
J. L. Shakin ◽  
J. S. Slakter ◽  
J. A. Sorenson ◽  
D. M. Shafer
Keyword(s):  
Proliferative Vitreoretinopathy ◽  
Panretinal Photocoagulation
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