11 Circadian Rhythm of Core Temperature, Blood Pressure and Heart Rate in Hypothyroid and Normal Rats

2015 ◽  
pp. 55-59
Author(s):  
P De Remigis ◽  
P Cugini ◽  
F Halberg ◽  
S Sensi ◽  
D Scavo
2008 ◽  
Vol 294 (2) ◽  
pp. F309-F315 ◽  
Author(s):  
Joo Lee Cham ◽  
Emilio Badoer

Redistribution of blood from the viscera to the peripheral vasculature is the major cardiovascular response designed to restore thermoregulatory homeostasis after an elevation in body core temperature. In this study, we investigated the role of the hypothalamic paraventricular nucleus (PVN) in the reflex decrease in renal blood flow that is induced by hyperthermia, as this brain region is known to play a key role in renal function and may contribute to the central pathways underlying thermoregulatory responses. In anesthetized rats, blood pressure, heart rate, renal blood flow, and tail skin temperature were recorded in response to elevating body core temperature. In the control group, saline was microinjected bilaterally into the PVN; in the second group, muscimol (1 nmol in 100 nl per side) was microinjected to inhibit neuronal activity in the PVN; and in a third group, muscimol was microinjected outside the PVN. Compared with control, microinjection of muscimol into the PVN did not significantly affect the blood pressure or heart rate responses. However, the normal reflex reduction in renal blood flow observed in response to hyperthermia in the control group (∼70% from a resting level of 11.5 ml/min) was abolished by the microinjection of muscimol into the PVN (maximum reduction of 8% from a resting of 9.1 ml/min). This effect was specific to the PVN since microinjection of muscimol outside the PVN did not prevent the normal renal blood flow response. The data suggest that the PVN plays an essential role in the reflex decrease in renal blood flow elicited by hyperthermia.


2009 ◽  
Vol 26 (8) ◽  
pp. 1636-1646 ◽  
Author(s):  
Hideyuki Shiotani ◽  
Yoichiro Umegaki ◽  
Maiko Tanaka ◽  
Madoka Kimura ◽  
Hiroshi Ando

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e348
Author(s):  
Eun Joo Cho ◽  
Byung Su Yoo ◽  
Mi Seung Shin ◽  
Ki Chul Sung ◽  
Eung Ju Kim ◽  
...  

1995 ◽  
Vol 12 (6) ◽  
pp. 419-426 ◽  
Author(s):  
Verghese Thomas ◽  
Wenyaw Chan ◽  
Robert Yetman ◽  
Michael H. Smolensky ◽  
Barry D. Kahan ◽  
...  

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e173
Author(s):  
B. Graff ◽  
A. Szyndler ◽  
A. Shalimova ◽  
M. Blaszkowska ◽  
J. Wolf ◽  
...  

1979 ◽  
Vol 57 (s5) ◽  
pp. 291s-294s ◽  
Author(s):  
S. Mann ◽  
M. W. Millar Craig ◽  
D. I. Melville ◽  
V. Balasubramanian ◽  
E. B. Raftery

1. Ambulatory blood pressure monitoring was carried out in 10 subjects for a period of 48 h, the first or second 24 h part of which was selected randomly to be a period of complete bed rest. 2. Heart rate was significantly lower throughout the period of bed rest except for the period 04.00–08.00 hours, when there was little difference. 3. The circadian variation of blood pressure was reduced during the day of bed rest but this was mainly due to higher night-time pressures.


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