Influence of Human Chorionic Gonadotropin and Prostaglandins on the Steroid Metabolism of the Perfused Human Placenta

1985 ◽  
pp. 162-164 ◽  
Author(s):  
A. S. Wolf ◽  
I. Henrichs ◽  
R. Benz ◽  
C. Lauritzen
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Placenta ◽  
Human Chorionic Gonadotropin ◽  
Steroid Metabolism

Human chorionic gonadotropin β-core fragment is present in the human placenta

1998 ◽  
Vol 139 (1-2) ◽  
pp. 171-178 ◽  
Author(s):  
Atsuko Udagawa ◽  
Tomomitsu Okamoto ◽  
Seiji Nomura ◽  
Katsuhiko Matsuo ◽  
Hideo Suzuki ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Placenta ◽  
Human Chorionic Gonadotropin ◽  
Core Fragment

Human chorionic gonadotropin downregulates AQP3 expression in human placenta

Placenta ◽  
2015 ◽  
Vol 36 (4) ◽  
pp. 495
Author(s):  
Di Paola Mauricio ◽  
Martínez Nora ◽  
Farina Mariana ◽  
Maskin Bernardo ◽  
Castro-Parodi Mauricio ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Placenta ◽  
Human Chorionic Gonadotropin

Prorenin secretion from human placenta perfused in vitro

1991 ◽  
Vol 260 (6) ◽  
pp. E876-E882 ◽  
Author(s):  
T. Lenz ◽  
G. D. James ◽  
J. H. Laragh ◽  
J. E. Sealey
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Placenta ◽  
Human Chorionic Gonadotropin ◽  
Maternal Circulation ◽  
Fetal Circulation ◽  
Active Renin ◽  
Tissue Extracts ◽  
No Activation

We examined whether renin (prorenin plus renin) is secreted from the human placenta into the maternal or fetal circulation and compared the secretion rate to that of human chorionic gonadotropin (hCG), progesterone, and estradiol. While estradiol and progesterone passed into both circulations, renin (mostly prorenin) and hCG were secreted predominantly into the maternal circulation. To examine if prorenin passed from the maternal to the fetal circulation and vice versa, we perfused both circuits separately with exogenous recombinant human prorenin. No prorenin passed from maternal to fetal circulations, but a small amount (less than 10%) slowly passed from fetal to maternal, beginning 15 min after the addition of prorenin. Exogenous prorenin was not converted to renin in either circulation. Perfusate total renin had close to 10% active renin, whereas that of tissue extracts was closer to 50%. In conclusion, the results are consistent with some tissue activation of prorenin, either in vitro or in vivo, but no activation in the maternal or fetal circulations. The human placenta may secrete prorenin into the maternal but not into the fetal circulation. The possibility that the placenta may secrete a small amount of active renin into the maternal circulation was not ruled out.

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