17 The FDA�s Good Laboratory Practices

2015 ◽  
pp. 113-118
Author(s):  
George W. James
Keyword(s):  
Good Laboratory

Good Practices in Evaluating the Uncertainty of Measurements for the Conductivity of the Electrolyte Solutions

2017 ◽  
Vol 68 (11) ◽  
pp. 2482-2487
Author(s):  
George Lazar ◽  
Claudiu Campureanu ◽  
Ioan Cirneanu ◽  
Danut Ionel Vaireanu
Keyword(s):  
Electrolyte Solutions ◽  
Theoretical Background ◽  
Conductivity Measurements ◽  
Expanded Uncertainty ◽  
Good Practices ◽  
Uncertainty Of Measurements ◽  
Good Laboratory

This paper intends to present the theoretical background as well as practical illustrations for good laboratory practices in conductivity measurements, ways to increase the accuracy of conductivity measurements as well as how one may evaluate the uncertainty of conductivity measurements for the electrolyte solutions. Practical measurements for prepared standards of 1 M KCl and 0.1 M KCl solutions are carried out and the values of repeatability, composed uncertainty and expanded uncertainty are presented.

scholarly journals SARS-CoV-2 serologic tests: do not forget the good laboratory practice

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Elena Aloisio ◽  
Felicia Stefania Falvella ◽  
Assunta Carnevale ◽  
Mauro Panteghini
Keyword(s):  
Good Laboratory Practice ◽  
Laboratory Practice ◽  
Serologic Tests ◽  
Good Laboratory

Good laboratory practice-compliant bio-efficacy testing of repellent products against Aedes aegypti

2021 ◽  
Author(s):  
R. Rosilawati ◽  
A. Ruziyatul Aznieda ◽  
A. Roziah ◽  
N. Ab Hamid ◽  
C. H. Teh ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Good Laboratory Practice ◽  
Laboratory Practice ◽  
Good Laboratory

scholarly journals Digital Management Systems in Academic Health Sciences Laboratories: A Scoping Review

Healthcare ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 739
Author(s):  
Margareth Timóteo ◽  
Emanuelle Lourenço ◽  
Ana Carolina Brochado ◽  
Luciana Domenico ◽  
Joice da Silva ◽  
...  
Keyword(s):  
Scoping Review ◽  
Health Sciences ◽  
Management Systems ◽  
Experimental Medicine ◽  
Academic Health ◽  
Good Practices ◽  
High Staff Turnover ◽  
Digital Management ◽  
Good Laboratory ◽  
Management Reporting

Good laboratory practices (GLP) increase the quality and traceability of results in health sciences research. However, factors such as high staff turnover, insufficient resources, and a lack of training for managers may limit their implementation in research and academic laboratories. This Scoping Review aimed to identify digital tools for managing academic health sciences and experimental medicine laboratories and their relationship with good practices. Following the PRISMA-ScR 2018 criteria, a search strategy was conducted until April 2021 in the databases PUBMED, Web of Sciences, and Health Virtual Library. A critical appraisal of the selected references was conducted, followed by data charting. The search identified twenty-one eligible articles, mainly originated from high-income countries, describing the development and/or implementation of thirty-two electronic management systems. Most studies described software functionalities, while nine evaluated and discussed impacts on management, reporting both improvements in the workflow and system limitations during implementation. In general, the studies point to a contribution to different management issues related to GLP principles. In conclusion, this review identified evolving evidence that digital laboratory management systems may represent important tools in compliance with the principles of good practices in experimental medicine and health sciences research.

Good Laboratory Practice (GLP) - guidelines for the acquisition and processing of electronic raw data in a GLP environment

2006 ◽  
Vol 10 (1) ◽  
pp. 3-14 ◽  
Author(s):  
Stephan Hassler ◽  
Gérard Donzé ◽  
Peter M. Esch ◽  
Bruno Eschbach ◽  
Hansruedi Hartmann ◽  
...  
Keyword(s):  
Good Laboratory Practice ◽  
Laboratory Practice ◽  
Raw Data ◽  
Good Laboratory

Managing the Bacterial Contamination Risk in an Axenic Mice Animal Facility

2021 ◽  
Author(s):  
Maria Lebeuf ◽  
Nathalie Turgeon ◽  
Cynthia Faubert ◽  
Justin Robillard ◽  
Eric Paradis ◽  
...  
Keyword(s):  
Bacterial Contamination ◽  
Microbial Control ◽  
Microbial Load ◽  
Bacillus Atrophaeus ◽  
Soaking Time ◽  
Log Reduction ◽  
Specific Pathogen ◽  
Sodium Dichloroisocyanurate ◽  
Good Laboratory ◽  
Control Procedures

A gap exists between good laboratory practises with axenic animals and procedures applied. This work aimed at choosing the appropriate disinfectant between sodium dichloroisocyanurate (MB-10) and potassium peroxymonosulfate (Virkon<sup>™</sup>) disinfectants and to adjust the soaking time of the material used with ISOcage biosafety stations. Another aim was to compare the microbial load on cage systems hosting mice since two weeks in axenic (AR) rooms and typical specific-pathogen-free (SPF) non-axenic rooms (NAR) to identify resistant microorganisms targeted for longer soaking disinfection as well as evaluate microbial concentration reduction procedures in AR. <i>Staphylococcus</i> was the most frequently isolated genus (AR and NAR). An average of three spore-forming microorganisms per cage were counted from AR. The disinfection time to reach 1 log reduction for <i>Bacillus atrophaeus</i> spores varied from 138 (100 ppm MB-10) to 290 (Virkon<sup>™</sup>) seconds and below 20 seconds for <i>S. epidermidis</i> (100 ppm MB-10). AR management protocols lead to 1000 times lower microorganisms burden compared to NAR. Data comparing microbial load on SPF and axenic facilities can be used as comparison for facilities aiming at improving the effectiveness of their microbial control procedures.

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