Vitamin A (Retinol) and Epithelial Cancer in Man

2015 ◽  
pp. 33-45
Author(s):  
T. K. Basu ◽  
Una Chan ◽  
A. Fields
Keyword(s):  
Nature ◽  
1979 ◽  
Vol 277 (5694) ◽  
pp. 261-262 ◽  
Author(s):  
Brigid Hogan
Keyword(s):  

Author(s):  
Bhawan B. Bhende

Vitamin A has important function in the body. Vitamin A is involved in growth, an reproduction. In this paper description, function and deficiency diseases of vitamin A has been delineated here with. Vitamin A is an essential micronutrient for the normal functioning of the visual system, growth and development, immunity and reproduction. Vitamin A is a constituent of visual pigment and maintains epithelium. It protects against some epithelial cancer Vitamin A being a potent antioxidant is required for cell regulation. To combat the deficiency of vitamin A in community, awareness of their importance and their source plays a vital role. Food-based approaches have been reviewed and judged to have a promising role in integrated strategies, but many gaps in knowledge were identified; more well-designed studies on efficacy, effectiveness, cost effectiveness, and sustainability of food-based approaches are needed. The main sources of preformed vitamin A or retinol are liver, whole milk, fish oil and egg. Vitamin A is present in many animal tissues and is readily absorbed from such dietary sources in the terminal small intestine.


Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti

Vacuolated cells in the liver of young rats were studied by light and electron microscopy following the administration of vitamin A (200 units per gram of body weight). Their characteristics were compared with similar cells found in untreated animals.In rats given vitamin A, cells with vacuolated cytoplasm were a prominent feature. These cells were found mostly in a perisinusoidal location, although some appeared to be in between liver cells (Fig. 1). Electron microscopy confirmed their location in Disse's space adjacent to the sinusoid and in recesses between liver cells. Some appeared to be bordering the lumen of the sinusoid, but careful observation usually revealed a tenuous endothelial process separating the vacuolated cell from the vascular space. In appropriate sections, fenestrations in the thin endothelial processes were noted (Fig. 2, arrow).


Author(s):  
J.C.S. Kim ◽  
M.G. Jourden ◽  
E.S. Carlisle

Chronic exposure to nitrogen dioxide in rodents has shown that injury reaches a maximum after 24 hours, and a reparative adaptive phase follows (1). Damage occurring in the terminal bronchioles and proximal portions of the alveolar ducts in rats has been extensively studied by both light and electron microscopy (1).The present study was undertaken to compare the response of lung tissue to intermittent exposure to 10 ppm of nitrogen dioxide gas for 4 hours per week, while the hamsters were on a vitamin A deficient diet. Ultrastructural observations made from lung tissues obtained from non-gas exposed, hypovitaminosis A animals and gas exposed animals fed a regular commercially prepared diet have been compared to elucidate the specific effect of vitamin A on nitrogen dioxide gas exposure. The interaction occurring between vitamin A and nitrogen dioxide gas has not previously been investigated.


1958 ◽  
Vol 35 (4) ◽  
pp. 381-386 ◽  
Author(s):  
Sidney M. Fierst ◽  
Saul M. Feldman ◽  
Nathan Solomon ◽  
Abraham Lanosam
Keyword(s):  

1952 ◽  
Vol 20 (4) ◽  
pp. 587-594 ◽  
Author(s):  
Frederick Steigmann ◽  
Hans Popper ◽  
Hattie Dyniewicz ◽  
Irene Maxwell

1950 ◽  
Vol 34 (2) ◽  
pp. 413-424 ◽  
Author(s):  
J.M. Lewis ◽  
Sidney Q. Cohlan
Keyword(s):  

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