Comparative Analysis of Melanoma-Associated Antigens in Primary and Metastatic Tumour Tissue

Author(s):  
J. Brüggen ◽  
E. -B. Bröcker ◽  
L. Suter ◽  
K. Redmann ◽  
C. Sorg
1982 ◽  
Vol 201 (1) ◽  
pp. 95-99 ◽  
Author(s):  
J A Alhadeff ◽  
R T Holzinger

An atypical thermolabile species of Hex B (hexosaminidase B) has been found in metastatic-tumour sites of human liver which has a thermostability curve similar to that of Hex A (hexosaminidase A), which is present in decreased amounts relative to the Hex A isoenzyme, and which exhibits decreased relative activity at acidic pH values (2.6-3.6) when compared with control-liver Hex B. This atypical Hex B isoenzyme has a normal apparent Michaelis constant (0.6 mM) for 4-methylumbelliferyl 2-deoxy-2-acetamido-beta-D-glucopyranoside. The presence of this atypical Hex B suggests that variant beta-chains are being produced in metastatic-tumour tissue.


2007 ◽  
Vol 177 (4S) ◽  
pp. 398-398
Author(s):  
Luis H. Braga ◽  
Joao L. Pippi Salle ◽  
Sumit Dave ◽  
Sean Skeldon ◽  
Armando J. Lorenzo ◽  
...  
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