Neuroendocrine Control of Ovarian Function in Higher Primates

2015 ◽  
pp. 11-27
Author(s):  
Ernst Knobil ◽  
Ludwig Wildt
Keyword(s):  
Ovarian Function ◽  
Neuroendocrine Control

scholarly journals Dopamine Inhibits Reproduction in Female Zebrafish (Danio rerio) via Three Pituitary D2 Receptor Subtypes

Endocrinology ◽  
2013 ◽  
Vol 154 (2) ◽  
pp. 807-818 ◽  
Author(s):  
Romain Fontaine ◽  
Pierre Affaticati ◽  
Kei Yamamoto ◽  
Cécile Jolly ◽  
Charlotte Bureau ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Gnrh Agonist ◽  
Ovarian Function ◽  
Gonadosomatic Index ◽  
D2 Receptor ◽  
Immunofluorescent Staining ◽  
Receptor Subtypes ◽  
Stimulatory Action ◽  
Neuroendocrine Control ◽  
Female Zebrafish

In many teleosts, the stimulatory control of gonadotrope axis by GnRH is opposed by an inhibitory control by dopamine (DA). The functional importance of this inhibitory pathway differs widely from one teleostean species to another. The zebrafish (Danio rerio) is a teleost fish that has become increasingly popular as an experimental vertebrate model. However, the role of DA in the neuroendocrine control of its reproduction has never been studied. Here the authors evaluated in sexually regressed female zebrafish the effects of in vivo treatments with a DA D2 receptor (D2-R) antagonist domperidone, or a GnRH agonist, alone and in combination, on the pituitary level of FSHβ and LHβ transcripts, the gonadosomatic index, and the ovarian histology. Only the double treatment with GnRH agonist and domperidone could induce an increase in the expression of LHβ, in the gonadosomatic index, and a stimulation of ovarian vitellogenesis, indicating that removal of dopaminergic inhibition is required for the stimulatory action of GnRH and reactivation of ovarian function to occur. Using double immunofluorescent staining on pituitary, the authors showed in this species the innervation of LH cells by tyrosine-hydroxylase immunoreactive fibers. Finally, using in situ hybridization and immunofluorescence, the authors showed that the three subtypes of zebrafish DA D2-R (D2a, D2b, and D2c) were expressed in LH-producing cells, suggesting that they all may be involved in mediating this inhibition. These results show for the first time that, in zebrafish, DA has a direct and potent inhibitory action capable of opposing the stimulatory effect of GnRH in the neuroendocrine control of reproduction.

THE CONTROL OF OVARIAN FUNCTION

1971 ◽  
Vol 66 (1) ◽  
pp. 1-15 ◽  
Author(s):  
B. T. Donovan
Keyword(s):  
Ovarian Function

Foetal steroid binding protein in British and Japanese women

1987 ◽  
Vol 114 (4) ◽  
pp. 584-588 ◽  
Author(s):  
M. Jawed Iqbal ◽  
Alastair Forbes ◽  
Mark L. Wilkinson ◽  
John W. Moore ◽  
Roger Williams ◽  
...  
Keyword(s):  
Ovarian Function ◽  
Binding Protein ◽  
Premenopausal Women ◽  
Japanese Women ◽  
Sex Hormone Binding Globulin ◽  
Partial Purification ◽  
Enzyme Linked Immunosorbent Assay ◽  
Binding Characteristics ◽  
Steroid Binding ◽  
Steroid Binding Protein

Abstract. In order to examine the newly-discovered sex-steroid binding protein, foetal steroid binding protein (FSBP) in different populations, its binding characteristics and its level were studied by two-tier column ligand binding assay and enzyme-linked immunosorbent assay (ELISA) respectively. In 10 Japanese premenopausal women, analysis of 5α-dihydrotestosterone (DHT) binding in the Cibacron Blue 3GA-Sepharose 6B portion of the column showed a rising plateau pattern with a mean maximum binding of 31.1 ± 7.41%, whereas of 9 similar British women, 8 displayed unsaturable, non-cooperative binding of 11.6 ± 8.22% (P < 0.01). After partial purification of FSBP in these samples, the protein exhibited saturable binding kinetics, median binding 25 (interquartiles 23–34) and 19 (13–25) nmol DHT/l in Japanese and British women, respectively (P < 0.05). By analyzing FSBP by ELISA in 56 Japanese (45 premenopausal) and 59 British (25 premenopausal) women, higher levels were obtained in the whole Japanese group (P = 0.0016) and in the premenopausal Japanese women (P = 0.018) than in their British counterparts. In both nationalities, FSBP levels were higher in premenopausal women, and there was a significant negative correlation of FSBP with age in both populations, particularly in postmenopausal women. FSBP levels did not correlate with weight, parity, sex hormone binding globulin or albumin levels. The influence of FSBP on free steroid levels remains unclear, but some relationship with ovarian function seems a possibility.

Ovarian function is associated with obesity in very long-term female survivors of childhood cancer

2013 ◽  
Author(s):  
Dorp Wendy van ◽  
Karin Blijdorp ◽  
Joop Laven ◽  
Rob Pieters ◽  
Jenny Visser ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Ovarian Function ◽  
Female Survivors ◽  
Survivors Of Childhood Cancer
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