19. Unstable Bladder Activity and the Rate of Resolution of Vesico-Ureteric Reflux1

2015 ◽  
pp. 238-246 ◽  
Author(s):  
C. M. Taylor
Keyword(s):  
Unstable Bladder ◽  
Bladder Activity

1619 EFFECTS OF INTRATHECAL INJECTION OF ALPHA-1A AND -1D ADRENOCEPTOR BLOCKERS ON BLADDER ACTIVITY IN SPINAL CORD INJURED RATS

2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Katsumi Kadekawa ◽  
Minoru Miyazato ◽  
Saori Nishijima ◽  
Katsuhiro Ashitomi ◽  
Kimio Sugaya
Keyword(s):  
Spinal Cord ◽  
Intrathecal Injection ◽  
Bladder Activity ◽  
Spinal Cord Injured

scholarly journals PKU2: AN ECONOMIC MODEL OF UNSTABLE BLADDER IN ITALY

2001 ◽  
Vol 4 (6) ◽  
pp. 448-449
Author(s):  
G Annoni ◽  
R Corey ◽  
M Bachleda ◽  
J Bentkover ◽  
EJ Stewart ◽  
...  
Keyword(s):  
Economic Model ◽  
Unstable Bladder

Sacral rootlet rhizotomy at the conus medullaris for hypertonic neurogenic bladder

1978 ◽  
Vol 48 (2) ◽  
pp. 193-196 ◽  
Author(s):  
Stanislaw K. Toczek ◽  
David C. McCullough ◽  
John S. Boggs
Keyword(s):  
Neurogenic Bladder ◽  
Smooth Muscle Contraction ◽  
Conus Medullaris ◽  
Detrusor Muscle ◽  
Urinary Frequency ◽  
Content Type ◽  
Bladder Activity ◽  
Root Stimulation

✓ Three patients with spastic neurogenic bladder underwent sacral root stimulation and appropriate section of motor rootlets to the detrusor at the level of the conus medullaris. Compared to the results obtained with rhizotomies at the sacral levels in a previous series of patients, urinary frequency and infection were inhibited for longer periods of time, but some uninhibited bladder activity recurred in all three patients. Analysis of anatomical and electrophysiological data serves to emphasize the complexity and asymmetry of efferent supply to detrusor muscle. The authors conclude that the role of selective rhizotomy for inhibition of the spastic bladder is inconclusive, and perhaps a combination of surgery and medications that inhibit smooth-muscle contraction may be required for long-term protection of urinary collection systems.

scholarly journals Role of spinal GABAA receptors in pudendal inhibition of nociceptive and nonnociceptive bladder reflexes in cats

2014 ◽  
Vol 306 (7) ◽  
pp. F781-F789 ◽  
Author(s):  
Zhiying Xiao ◽  
Jeremy Reese ◽  
Zeyad Schwen ◽  
Bing Shen ◽  
Jicheng Wang ◽  
...  
Keyword(s):  
Gabaa Receptors ◽  
Bladder Capacity ◽  
Aminobutyric Acid ◽  
Saline Control ◽  
Receptor Subtype ◽  
High Dose ◽  
Multiple Threshold ◽  
Bladder Activity ◽  
Subtype A

Picrotoxin, an antagonist for γ-aminobutyric acid receptor subtype A (GABAA), was used to investigate the role of GABAA receptors in nociceptive and nonnociceptive reflex bladder activities and pudendal inhibition of these activities in cats under α-chloralose anesthesia. Acetic acid (AA; 0.25%) was used to irritate the bladder and induce nociceptive bladder overactivity, while saline was used to distend the bladder and induce nonnociceptive bladder activity. To modulate the bladder reflex, pudendal nerve stimulation (PNS) was applied at multiple threshold (T) intensities for inducing anal sphincter twitching. AA irritation significantly ( P < 0.01) reduced bladder capacity to 34.3 ± 7.1% of the saline control capacity, while PNS at 2T and 4T significantly ( P < 0.01) increased AA bladder capacity to 84.0 ± 7.8 and 93.2 ± 15.0%, respectively, of the saline control. Picrotoxin (0.4 mg it) did not change AA bladder capacity but completely removed PNS inhibition of AA-induced bladder overactivity. Picrotoxin (iv) only increased AA bladder capacity at a high dose (0.3 mg/kg) but significantly ( P < 0.05) reduced 2T PNS inhibition at low doses (0.01–0.1 mg/kg). During saline cystometry, PNS significantly ( P < 0.01) increased bladder capacity to 147.0 ± 7.6% at 2T and 172.7 ± 8.9% at 4T of control capacity, and picrotoxin (0.4 mg it or 0.03–0.3 mg/kg iv) also significantly ( P < 0.05) increased bladder capacity. However, picrotoxin treatment did not alter PNS inhibition during saline infusion. These results indicate that spinal GABAA receptors have different roles in controlling nociceptive and nonnociceptive reflex bladder activities and in PNS inhibition of these activities.

scholarly journals Activation of Muscarinic Receptors in Rat Bladder Sensory Pathways Alters Reflex Bladder Activity

2008 ◽  
Vol 28 (8) ◽  
pp. 1977-1987 ◽  
Author(s):  
F. A. Kullmann ◽  
D. E. Artim ◽  
L. A. Birder ◽  
W. C. de Groat
Keyword(s):  
Muscarinic Receptors ◽  
Sensory Pathways ◽  
Rat Bladder ◽  
Bladder Activity

The Unstable Bladder

1985 ◽  
Vol 12 (2) ◽  
pp. 317-328
Author(s):  
A.R. Mundy
Keyword(s):  
Unstable Bladder
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