Reduction in Regional Cerebral Blood Flow during Normal Aging Is Not Limited to Elderly Subjects1

2015 ◽  
pp. 139-143
Author(s):  
Mordecai Globus ◽  
Gerald Cooper ◽  
Eldad Melamed
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Aging ◽  
Regional Cerebral Blood

scholarly journals Reduction in regional cerebral blood flow during normal aging in man.

Stroke ◽  
1980 ◽  
Vol 11 (1) ◽  
pp. 31-35 ◽  
Author(s):  
E Melamed ◽  
S Lavy ◽  
S Bentin ◽  
G Cooper ◽  
Y Rinot
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Aging ◽  
Regional Cerebral Blood

scholarly journals Evaluation of Regional Cerebral Blood Flow Changes in Normal Aging Using 99mTc-ECD SPECT and Patlak Method.

RADIOISOTOPES ◽  
1998 ◽  
Vol 47 (5) ◽  
pp. 392-398 ◽  
Author(s):  
Shinji MIZUNO ◽  
Yuka NANDATE ◽  
Mayumi ENYA ◽  
Tomoko MANABE ◽  
Hiroo GOTO ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Aging ◽  
Regional Cerebral Blood ◽  
Flow Changes

IC-P-101: Longitudinal Regional Cerebral Blood Flow Change Due to Normal Aging: A Community-Based Study

2010 ◽  
Vol 6 ◽  
pp. S41-S41
Author(s):  
Kiyotaka Nemoto ◽  
Fumio Yamashita ◽  
Chiine Kodama ◽  
Masashi Tamura ◽  
Hiroshi Matsuda ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Aging ◽  
Regional Cerebral Blood ◽  
Community Based ◽  
Blood Flow Change ◽  
Flow Change ◽  
Cerebral Blood Flow Change

scholarly journals Decreases in Regional Cerebral Blood Flow with Normal Aging

1991 ◽  
Vol 11 (4) ◽  
pp. 684-689 ◽  
Author(s):  
Andrew J. Martin ◽  
Karl J. Friston ◽  
James G. Colebatch ◽  
Richard S. J. Frackowiak
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Aging ◽  
Regional Cerebral Blood ◽  
Cognitive Changes ◽  
Age Related ◽  
Positron Emission ◽  
Posterior Parietal ◽  
Parietal Cortices

Positron emission tomographic (PET) images of regional cerebral blood flow (rCBF) from 30 normal, resting volunteers aged 30 to 85 years were analysed to identify areas where rCBF fell with age. Images were anatomically normalised, and a pixel-by-pixel linear regression was performed to remove differences in global CBF between subjects. Pixels at which rCBF then showed a significant ( p < 0.01) negative correlation with age were identified. They were displayed as a statistical parametric map (SPM) of correlations. We demonstrate an age-related decrease in adjusted rCBF in the cingulate, parahippocampal, superior temporal, medial frontal, and posterior parietal cortices bilaterally, and in the left insular and left posterior prefrontal cortices (omnibus significance, χ2 = 2,291, p < 0.0001, df = 1). Decreases in rCBF suggest a regionally specific loss of cerebral function with age. The affected areas were all limbic, or association, cortices. Therefore, these decreases may constitute the cerebral substrate of the cognitive changes that occur during normal aging.

Regional cerebral blood flow in normal aging: A 2-years longitudinal evaluation using a 99mTc-HMPAO brain spect activation protocol

NeuroImage ◽  
2000 ◽  
Vol 11 (5) ◽  
pp. S91
Author(s):  
Catherine Ludwig ◽  
Christian Chicherio ◽  
Luc Terraneo ◽  
Anik de Ribaupierre ◽  
Ezio Giacobini ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Aging ◽  
Brain Spect ◽  
Regional Cerebral Blood ◽  
Longitudinal Evaluation ◽  
99Mtc Hmpao

Regional cerebral blood flow in schizophrenia while performing an attention task

2014 ◽  
Author(s):  
Scott Harcourt ◽  
Daniel G. Amen ◽  
Kristin C. Willeumier ◽  
Charles J. Golden
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Attention Task

Vorläufige Ergebnisse von 99mTc-HMPAO-SPECT-Untersuchungen bei endogenen Psychosen

1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Post Mortem ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
The Brain ◽  
99Mtc Hmpao

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

133Xe-DSPECT: Normalwerte von zerebraler Ruhedurchblutung und Reservekapazität

1987 ◽  
Vol 26 (05) ◽  
pp. 192-197 ◽  
Author(s):  
T. Kreisig ◽  
P. Schmiedek ◽  
G. Leinsinger ◽  
K. Einhäupl ◽  
E. Moser
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebrovascular Disease ◽  
Correlation Coefficient ◽  
Regional Cerebral Blood Flow ◽  
Regression Line ◽  
Reserve Capacity ◽  
Regional Cerebral Blood ◽  
Quantitative Measurements ◽  
Before And After

Using the 133Xe-DSPECT technique, quantitative measurements of regional cerebral blood flow (rCBF) were performed before and after provocation with acetazolamide (Diamox) i. v. in 32 patients without evidence of brain disease (normals). In 6 cases, additional studies were carried out to establish the time of maximal rCBF increase which was found to be approximately 15 min p. i. 1 g of Diamox increases the rCBF from 58 ±8 at rest to 73±5 ml/100 g/min. A Diamox dose of 2 g (9 cases) causes no further rCBF increase. After plotting the rCBF before provocation (rCBFR) and the Diamox-induced rCBF increase (reserve capacity, Δ rCBF) the regression line was Δ rCBF = −0,6 x rCBFR +50 (correlation coefficient: r = −0,77). In normals with relatively low rCBF values at rest, Diamox increases the reserve capacity much more than in normals with high rCBF values before provocation. It can be expected that this concept of measuring rCBF at rest and the reserve capacity will increase the sensitivity of distinguishing patients with reversible cerebrovascular disease (even bilateral) from normals.

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