Early Structural Signs of Peripheral Neuropathy in Animal Models of Diabetes Mellitus

2015 ◽  
pp. 163-174
Author(s):  
Soroku Yagihashi ◽  
Masaei Kakizaki ◽  
Yoshio Goto
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Animal Models ◽  
Animal Models Of Diabetes

Noninsulin-Dependent Animal Models of Diabetes Mellitus

2018 ◽  
pp. 337-398
Author(s):  
Christopher H. S. McIntosh ◽  
Raymond A. Pederson
Keyword(s):  
Diabetes Mellitus ◽  
Animal Models ◽  
Animal Models Of Diabetes

scholarly journals Animal Models of Diabetes Mellitus for Islet Transplantation

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Naoaki Sakata ◽  
Gumpei Yoshimatsu ◽  
Haruyuki Tsuchiya ◽  
Shinichi Egawa ◽  
Michiaki Unno
Keyword(s):  
Diabetes Mellitus ◽  
Animal Models ◽  
Islet Transplantation ◽  
Diabetic Animal ◽  
Islet Isolation ◽  
Loss Of Function ◽  
Severe Diabetes ◽  
Animal Models Of Diabetes ◽  
Type 1 Dm

Due to current improvements in techniques for islet isolation and transplantation and protocols for immunosuppressants, islet transplantation has become an effective treatment for severe diabetes patients. Many diabetic animal models have contributed to such improvements. In this paper, we focus on 3 types of models with different mechanisms for inducing diabetes mellitus (DM): models induced by drugs including streptozotocin (STZ), pancreatomized models, and spontaneous models due to autoimmunity. STZ-induced diabetes is one of the most commonly used experimental diabetic models and is employed using many specimens including rodents, pigs or monkeys. The management of STZ models is well established for islet studies. Pancreatomized models reveal different aspects compared to STZ-induced models in terms of loss of function in the increase and decrease of blood glucose and therefore are useful for evaluating the condition in total pancreatomized patients. Spontaneous models are useful for preclinical studies including the assessment of immunosuppressants because such models involve the same mechanisms as type 1 DM in the clinical setting. In conclusion, islet researchers should select suitable diabetic animal models according to the aim of the study.

Plasma sialic acid in animal models of diabetes mellitus: Evidence for modulation of sialic acid concentrations by insulin deficiency

Life Sciences ◽  
1995 ◽  
Vol 57 (14) ◽  
pp. 1383-1391 ◽  
Author(s):  
John C. Pickup ◽  
Caroline Day ◽  
Clifford J. Bailey ◽  
Alison Samuel ◽  
Gary D. Chusney ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Sialic Acid ◽  
Animal Models ◽  
Insulin Deficiency ◽  
Animal Models Of Diabetes
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