The Evolution and Complexity of the Genes Encoding the Cytoskeletal Proteins of Human Epidermal Cells

2015 ◽  
pp. 27-44 ◽  
Author(s):  
Elaine Fuchs ◽  
Kwan Hee Kim ◽  
Israel Hanukoglu ◽  
Naoko Tanese
Keyword(s):  
Epidermal Cells ◽  
Cytoskeletal Proteins ◽  
Human Epidermal Cells ◽  
Genes Encoding

scholarly journals Use of Human Epidermal Cells in the Study of Carcinogenesis

1989 ◽  
Vol 92 (5) ◽  
pp. S271-S274 ◽  
Author(s):  
Toshio Kuroki ◽  
Kazuhiro Chida ◽  
Jiro Hosomi ◽  
Seiji Kondo
Keyword(s):  
Epidermal Cells ◽  
Human Epidermal Cells

scholarly journals Rsp5p, a New Link between the Actin Cytoskeleton and Endocytosis in the Yeast Saccharomyces cerevisiae

2002 ◽  
Vol 22 (20) ◽  
pp. 6946-6948 ◽  
Author(s):  
Joanna Kamińska ◽  
Beata Gajewska ◽  
Anita K. Hopper ◽  
Teresa ˙Zołądek
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Actin Cytoskeleton ◽  
Cytoskeletal Proteins ◽  
Wild Type ◽  
Yeast Saccharomyces Cerevisiae ◽  
Ww Domains ◽  
Ubiquitin Protein Ligase ◽  
Growth Defects ◽  
Genes Encoding ◽  
Cytoskeleton Dynamics

ABSTRACT Rsp5p is an ubiquitin-protein ligase of Saccharomyces cerevisiae that has been implicated in numerous processes including transcription, mitochondrial inheritance, and endocytosis. Rsp5p functions at multiple steps of endocytosis, including ubiquitination of substrates and other undefined steps. We propose that one of the roles of Rsp5p in endocytosis involves maintenance and remodeling of the actin cytoskeleton. We report the following. (i) There are genetic interactions between rsp5 and several mutant genes encoding actin cytoskeletal proteins. rsp5 arp2, rsp5 end3, and rsp5 sla2 double mutants all show synthetic growth defects. Overexpressed wild-type RSP5 or mutant rsp5 genes with lesions of some WW domains suppress growth defects of arp2 and end3 cells. The defects in endocytosis, actin cytoskeleton, and morphology of arp2 are also suppressed. (ii) Rsp5p and Sla2p colocalize in abnormal F-actin-containing clumps in arp2 and pan1 mutants. Immunoprecipitation experiments confirmed that Rsp5p and Act1p colocalize in pan1 mutants. (iii) Rsp5p and Sla2p coimmunoprecipitate and partially colocalize to punctate structures in wild-type cells. These studies provide the first evidence for an interaction of an actin cytoskeleton protein with Rsp5p. (iv) rsp5-w1 mutants are resistant to latrunculin A, a drug that sequesters actin monomers and depolymerizes actin filaments, consistent with the fact that Rsp5p is involved in actin cytoskeleton dynamics.

scholarly journals Redistribution of Transcription Factor AP-2α in Differentiating Cultured Human Epidermal Cells

2001 ◽  
Vol 117 (4) ◽  
pp. 864-870 ◽  
Author(s):  
Olga M. Mazina ◽  
Marjorie A. Phillips ◽  
Trevor Williams ◽  
Carol A. Vines ◽  
Gary N. Cherr ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Epidermal Cells ◽  
Human Epidermal Cells

DNA damaging potential of zinc oxide nanoparticles in human epidermal cells

2009 ◽  
Vol 185 (3) ◽  
pp. 211-218 ◽  
Author(s):  
Vyom Sharma ◽  
Ritesh K. Shukla ◽  
Neha Saxena ◽  
Devendra Parmar ◽  
Mukul Das ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Epidermal Cells ◽  
Oxide Nanoparticles ◽  
Human Epidermal Cells
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