Combined Modality Treatment in the Athymic Mouse-Human Brain Tumor Xenograft Model

2015 ◽  
pp. 304-310
Author(s):  
Don E. Slagel ◽  
Jos� Feola ◽  
Dave P. Houchens ◽  
Artemio A. Ovejera
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
Xenograft Model ◽  
Tumor Xenograft ◽  
Combined Modality Treatment ◽  
Athymic Mouse ◽  
Human Brain Tumor ◽  
Combined Modality

Enhanced Delivery Improves the Efficacy of a Tumor-specific Doxorubicin Immunoconjugate in a Human Brain Tumor Xenograft Model

Neurosurgery ◽  
2000 ◽  
Vol 46 (3) ◽  
pp. 704-709 ◽  
Author(s):  
Laura G. Remsen ◽  
Pamela A. Trail ◽  
Ingegerd Hellström ◽  
Karl Erik Hellström ◽  
Edward A. Neuwelt
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
Xenograft Model ◽  
Tumor Xenograft ◽  
Human Brain Tumor

scholarly journals Magnetic Resonance Microscopy at 14 Tesla and Correlative Histopathology of Human Brain Tumor Tissue

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27442 ◽  
Author(s):  
Ana Gonzalez-Segura ◽  
Jose Manuel Morales ◽  
Jose Manuel Gonzalez-Darder ◽  
Ramon Cardona-Marsal ◽  
Concepcion Lopez-Gines ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Magnetic Resonance ◽  
Human Brain ◽  
Tumor Tissue ◽  
Magnetic Resonance Microscopy ◽  
Human Brain Tumor

Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 by human brain tumors

1994 ◽  
Vol 81 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Takao Nakagawa ◽  
Toshihiko Kubota ◽  
Masanori Kabuto ◽  
Kazufumi Sato ◽  
Hirokazu Kawano ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Matrix Metalloproteinases ◽  
Brain Tumors ◽  
Human Brain ◽  
Tumor Cells ◽  
Tumor Invasion ◽  
Gelatinolytic Activity ◽  
Normal Brain ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Human Brain Tumor

✓ The role of matrix metalloproteinases (MMP's) and their inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1), in human brain tumor invasion was investigated. Gelatinolytic activity was assayed via gelatin zymography, and four MMP's (MMP-1, MMP-2, MMP-3, and MMP-9) and TIMP-1 were immunolocalized in human brain tumors and in normal brain tissues using monoclonal antibodies. The tissue was surgically removed from 44 patients: glioblastoma (five cases), anaplastic astrocytoma (six cases), astrocytoma (four cases), metastatic tumor (six cases), neurinoma (10 cases), meningioma (10 cases), and normal brain tissue (three cases). Glioblastomas, anaplastic astrocytomas, and metastatic tumors showed high gelatinolytic activity and positive immunostaining for MMP's; TIMP-1 was also expressed in these tumors, but some tumor cells were negative for the antibody. Astrocytomas had low gelatinolytic activity and the tumor cells showed no immunoreactivity for MMP's and TIMP-1. Although neurinomas and meningiomas had only moderate proteinase activity and exhibited positive immunoreactivity for MMP-9, intense expression of TIMP-1 was simultaneously observed in these tumor cells. These findings suggest that MMP's play an important role in human brain tumor invasion, probably due to an imbalance between the production of MMP's and TIMP-1 by the tumor cells.

scholarly journals Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients

2016 ◽  
Vol 18 (9) ◽  
pp. 1209-1218 ◽  
Author(s):  
Amy K. LeBlanc ◽  
Christina Mazcko ◽  
Diane E. Brown ◽  
Jennifer W. Koehler ◽  
Andrew D. Miller ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
Tumor Patients ◽  
Human Brain Tumor ◽  
New Knowledge

scholarly journals Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Susobhan Sarkar ◽  
Candice C. Poon ◽  
Reza Mirzaei ◽  
Khalil S. Rawji ◽  
Walter Hader ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
Tumor Initiating Cells ◽  
Human Brain Tumor ◽  
Brain Tumor Initiating Cells

scholarly journals Expression of CYP1A1 and GSTP1 in Human Brain Tumor Tissues in Pakistan

2013 ◽  
Vol 14 (12) ◽  
pp. 7187-7191 ◽  
Author(s):  
Mussarat Wahid ◽  
Ishrat Mahjabeen ◽  
Ruqia Mehmood Baig ◽  
Mahmood Akhtar Kayani
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
Human Brain Tumor ◽  
Tumor Tissues
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